Results 131 to 140 of about 21,463 (243)

Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Intramuscular fat (IMF), also known as myosteatosis, refers to the accumulation of lipids within and around skeletal muscle fibres. Excess IMF is increasingly recognised as a sign of poor muscle quality, linked to reductions in strength, power and mobility, and associated with adverse outcomes in metabolic disease, osteoarthritis ...
Christopher Spence, Martin Alberto Belzunce, Anna Di Laura, Johann Henckel, Alister J. Hart   +4 more
wiley   +1 more source

Recent Advances in Oriented Hydrogels: From Fundamental Mechanisms to Future Challenges

SusMat, Volume 6, Issue 5, October 2026.
Traditional hydrogels suffer from weak mechanical properties and limited functionality due to their random polymer networks. This review comprehensively summarizes the reinforcement mechanisms of oriented structure for hydrogels, the design/fabrication strategies, and the latest application progress of high‐strength oriented hydrogels.
Chang Xu, Xijing Zhuang
wiley   +1 more source

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

Interplay between store‐operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise

The Journal of Physiology, Volume 604, Issue 20, Page 8379-8427, 15 October 2026.
Abstract figure legend This study uses systems modelling to demonstrate a role of SOCE in sustained force generation during exercise. SOCE leads to two competing effects on contractile force in myofibres – increased cross‐bridge cycling due to elevated myoplasmic Ca2+$\text{Ca}^{2+}$ enhances force, whereas increased accumulation of myoplasmic ...
Emmet A. Francis, Juliette Hamid, Anusha Kumar, Padmini Rangamani   +3 more
wiley   +1 more source

Using iPALM to determine protein organisation in cardiac muscle Z-discs. [PDF]

PLoS Comput Biol
Umney O, Curd AP, Martin HL, Lewis T, Tang AA, Gaule T, Manfield IW, Balasubramanian H, Khuon S, Aaron J, Peckham M.   +10 more
europepmc   +2 more sources

Can We Study Titin Properties in Passive Myofibrils? [PDF]

, 2011
Titin is a giant molecular spring in skeletal and cardiac muscles. It has a variety of important passive, structural, sensing and force-regulatory functions, and thus has been investigated widely (Granzier & Labeit, 2007).
Herzog, W., Leonard, T. R., Herzog, J., Jinha, A.   +3 more
core  

Muscle residual force enhancement: a brief review

Clinics, 2013
Muscle residual force enhancement has been observed in different muscle preparations for more than half a century. Nonetheless, its mechanism remains unclear; to date, there are three generally accepted hypotheses: 1) sarcomere length non-uniformity, 2 ...
Fábio Carderelli Minozzo, Claudio Andre Barbosa de Lira   +1 more
doaj  

Degradation of Rat Cardiac Myofibrils and Myofibrillar Proteins by a Myosin-Cleaving Protease

, 1979
The degradation of rat cardiac myofibrils and their constituent proteins with a myosin-cleav-ing protease was studied. Electrophoretograms of the digestion products of myofibrils showed that myosin.M-protein, C-protein, and troponin were degraded, but ...
Umeji Murakami, Koki Uchida
core  

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Subsarcomeric regulation of thin and thick filaments in skeletal muscle myofibrils. [PDF]

Proc Natl Acad Sci U S A
Sliogeryte K, Fusi L.
europepmc   +2 more sources