Results 91 to 100 of about 53,888 (279)

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

The first embryonic landscape of G-quadruplexes related to myogenesis

BMC Biology
Background DNA G-quadruplexes (G4s) represent a distinctive class of non-canonical DNA secondary structures. Despite their recognition as potential therapeutic targets in some cancers, the developmental role of G4 structures remains enigmatic.
Lijin Guo, Weiling Huang, Qi Wen, Siyu Zhang, Farhad Bordbar, Zhengzhong Xiao, Qinghua Nie   +6 more
doaj   +1 more source

Global transcriptomic analysis reveals Lnc-ADAMTS9 exerting an essential role in myogenesis through modulating the ERK signaling pathway

Journal of Animal Science and Biotechnology, 2021
Background Long non-coding RNAs (lncRNAs) are emerging key regulators involved in a variety of biological processes such as cell differentiation and development.
Liqi Wang, Ting He, Xin Zhang, Yubo Wang, Kai Qiu, Ning Jiao, Linjuan He, Jingdong Yin   +7 more
doaj   +1 more source

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization [PDF]

, 2017
PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference.
Aversa, Antonio, Bimonte, VIVIANA MARIA, Crescioli, Clara, Di Luigi, Luigi, Fittipaldi, Simona, Francomano, Davide, Greco, Emanuela A., Lenzi, Andrea, Migliaccio, Silvia   +8 more
core   +1 more source

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, EarlyView.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells. [PDF]

PLoS ONE, 2016
Myogenesis and muscle hypertrophy account for muscle growth and adaptation to work overload, respectively. In adults, insulin and insulin-like growth factor 1 stimulate muscle growth, although their links with cellular energy homeostasis are not fully ...
Anna Litwiniuk, Barbara Pijet, Maja Pijet-Kucicka, Małgorzata Gajewska, Beata Pająk, Arkadiusz Orzechowski   +5 more
doaj   +1 more source

Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy [PDF]

, 2016
Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a ...
Hildyard, J C W, Wells, D J
core   +1 more source

Prolonged Cell Encapsulation and Gravity‐independent Filamented Light Biofabrication of Muscle Constructs

Advanced Science, EarlyView.
A gravity‐independent filamented light (G‐FLight) projection method is presented for rapid biofabrication of anisotropic tissues, demonstrated with muscle constructs as a target application. Specialized photocrosslinkable resins enable refrigeration or cryopreservation with encapsulated cells.
Michael Winkelbauer, Jakub Janiak, Johannes Windisch, Hao Liu, Maria Bulatova, Max Von Witzleben, Hugo Oliveira, Sophie Dani, Richard Frank Richter, Nicolas L’Heureux, Ori Bar‐Nur, Michael Gelinsky, Marcy Zenobi‐Wong, Parth Chansoria   +13 more
wiley   +1 more source

The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation

Scientific Reports, 2021
The process of myogenesis which operates during skeletal muscle regeneration involves the activation of muscle stem cells, the so-called satellite cells.
Tannaz Norizadeh Abbariki, Zita Gonda, Denise Kemler, Pavel Urbanek, Tabea Wagner, Margarethe Litfin, Zhao-Qi Wang, Peter Herrlich, Olivier Kassel   +8 more
doaj   +1 more source

Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice [PDF]

, 1993
In developing mouse embryos, MyoD family regulatory genes are expressed specifically in muscle precursors and mature myofibers. This pattern, taken together with the well-established ability of MyoD family members to convert a variety of cell types to ...
Lyons, Gary E., Miner, Jeffrey H., Patapoutian, Ardem, Wold, Barbara   +3 more
core