Results 111 to 120 of about 41,288 (271)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Stk24 promotes myogenic differentiation via multiple mechanisms

, 2011
Through an RNAi-based screening for kinases involved in myogenic differentiation, we identified Stk24/MST3, a member of the mammalian Ste20 family, as a key regulator.
Wang, Xi
core  

A spatiotemporal single‐cell atlas of porcine development reveals regulatory dynamics and cellular targets of domestication

iMeta, EarlyView.
This study presents a cross‐tissue, single‐cell/single‐nucleus transcriptomic atlas spanning from prenatal to postnatal developmental stages in pig, characterizing 83 distinct cell types from 252,033 cells. Through the construction of cross‐tissue transcriptional regulatory networks and pseudotime trajectories, we revealed that organogenesis is driven ...
Rong Zhou, Zishuai Wang, Chenghao Hu, Shuhan Deng, Changyun Cai, Yanfang Wang, Shang‐Tong Li, Lijing Bai, Kui Li   +8 more
wiley   +1 more source

Notch pathway activation contributes to inhibition of C2C12 myoblast differentiation by ethanol.

PLoS ONE, 2013
The loss of muscle mass in alcoholic myopathy may reflect alcohol inhibition of myogenic cell differentiation into myotubes. Here, using a high content imaging system we show that ethanol inhibits C2C12 myoblast differentiation by reducing myogenic ...
Michelle A Arya, Albert K Tai, Eric C Wooten, Christopher D Parkin, Elena Kudryavtseva, Gordon S Huggins   +5 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Potential Role of Omega-3 Fatty Acids on the Myogenic Program of Satellite Cells

, 2016
Skeletal muscle loss is associated with aging as well as pathological conditions. Satellite cells (SCs) play an important role in muscle regeneration.
Amritpal S. Bhullar, Charles T. Putman, Amritpal S. Bhullar M.sc, Vera C. Mazurak PhD, Vera C. Mazurak, Charles T. Putman PhD   +5 more
core   +1 more source

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source

Adiponectin regulates proliferation and differentiation of chicken skeletal muscle satellite cells via ERK1/2 and p38 signaling pathways

Poultry Science
Skeletal muscle satellite cells (SMSCs) are critical for postnatal skeletal muscle growth and regeneration. Adiponectin plays a pivotal role in regulating muscle glucose uptake and fatty acid metabolism.
Liping Guo, Kaiming Jin, Qi Sun, Chenchao Zhang, Xiongyong Chen, Zhaoyu Geng   +5 more
doaj   +1 more source

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.

PLoS Genetics, 2017
The TEAD family of transcription factors (TEAD1-4) bind the MCAT element in the regulatory elements of both growth promoting and myogenic differentiation genes.
Shilpy Joshi, Guillaume Davidson, Stéphanie Le Gras, Shuichi Watanabe, Thomas Braun, Gabrielle Mengus, Irwin Davidson   +6 more
doaj   +1 more source

Embryonic temperature and the genes regulating myogenesis in teleosts

, 2008
In this study, full coding sequences of Atlantic salmon (Salmo salar L.) muscle genes were cloned, including myogenic regulatory factors (MRFs) (myod1c, myog, mrf4, myf5), inhibitors of Myostatin (fst, decorin), markers of myogenic progenitor cell (MPC ...
Macqueen, Daniel J.
core