Results 121 to 130 of about 814,354 (242)

LMOD2 interaction with ACTC1 regulates myogenic differentiation

BMC Genomics
Skeletal muscle is the largest tissue in mammals, and it plays a crucial role in metabolism and homeostasis. Skeletal muscle development and regeneration consist of a series of carefully regulated changes in gene expression. Leiomodin2 (LMOD2) gene is specifically expressed in the heart and skeletal muscle.
Kaiming, Wang, Caihong, Liu, Lei, Yi, Sui, Liufu, Wenwu, Chen, Xiaolin, Liu, Bohe, Chen, Xin, Xu, Jingwen, Liu, Xibing, Liu, Yulong, Yin, Haiming, Ma   +11 more
openaire   +2 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Germline Cancer Predisposition and De Novo Contributions in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group

International Journal of Cancer, EarlyView.
ABSTRACT Approximately 6%–8% of children and adolescents with rhabdomyosarcoma (RMS) have an underlying cancer predisposition disorder (CPD), which varies between embryonal and alveolar subtypes and other clinical characteristics. Identifying a CPD remains challenging, as traditional approaches rely on clinical features and family history. Additionally,
Taylor M. Luckie, Sarah Scollon, Yao Yu, Aniko Sabo, Tiffany Chambers, Olga Taylor, Logan G. Spector, Michael E. Scheurer, Douglas S. Hawkins, Rajkumar Venkatramani, Chad D. Huff, Sharon E. Plon, Philip J. Lupo   +12 more
wiley   +1 more source

Characterization of the Epigenetic Signature Underlying Early Myogenic Differentiation

, 2019
Although skeletal myogenesis is largely controlled by myogenic regulatory factors, epigenetic modifications have recently emerged as an essential regulatory mechanism of gene expression.
Hamed, Munerah
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Stk24 promotes myogenic differentiation via multiple mechanisms

, 2011
Through an RNAi-based screening for kinases involved in myogenic differentiation, we identified Stk24/MST3, a member of the mammalian Ste20 family, as a key regulator.
Wang, Xi
core  

PIP5K1α promotes myogenic differentiation via AKT activation and calcium release

, 2018
Background Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration. Many intracellular signaling pathways are essential for myogenic differentiation, while a number of kinases ...
Xiaofan Chen, Yarui Diao, Wei Zhang, Jun Wan, Bo Yu   +4 more
core   +1 more source

Advances in the Protective Effects and Mechanisms of β‐Aminoisobutyric Acid in Maintaining Multi‐Organ Homeostasis

Medicine Bulletin, EarlyView.
ABSTRACT β‐Aminoisobutyric acid (BAIBA) is an exercise‐responsive myokine/metabolite released by skeletal muscle and has attracted increasing interest as a potential exercise mimetic and therapeutic candidate in preclinical research. BAIBA acts locally in skeletal muscle and can also reach distal organs through the circulation, contributing to the ...
Hao‐Zhe Wang, Wen‐Bi He, Fei‐Peng Chen, Jiong‐Xing Huang, Lin Zhu, Xiao‐Guang Liu   +5 more
wiley   +1 more source

High-density ZnO Nanowires as a Reversible Myogenic-Differentiation-Switch

, 2018
Mesoangioblasts are outstanding candidates for stem cell therapy and are already being explored in clinical trials. However, a crucial challenge in regenerative medicine is the limited availability of undifferentiated myogenic progenitor cells, since ...
Cesare Gargioli, Testa, Stefano, Falconi, C, Fuoco C., Fuoco, Claudia, Testa S., Fornetti, Ersilia, Giovanni Saggio, Desideri A., Rufini, Stefano, Saggio G., Arrabito G., Testa, S, Errico, Vito, Gargioli C., Fuoco, C, Errico V., Christian Falconi, Cannata, Stefano Maria, Falconi, Christian, Vito Errico, Stefano Cannata, Fornetti, E, Falconi C., Rufini S., Cannata S., Rufini, S, Errico, V, Cannata, S, Arrabito, G, Stefano Testa, Alessandro Desideri, Desideri, A, Stefano Rufini, Gargioli, Cesare, Gargioli, C, Saggio, Giovanni, Fornetti E., Arrabito, Giuseppe, Desideri, Alessandro, Ersilia Fornetti, Giuseppe Arrabito, Saggio, G, Claudia Fuoco   +43 more
core   +2 more sources

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source