Results 61 to 70 of about 41,288 (271)

Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.

PLoS ONE, 2023
Muscles that are injured or atrophied by aging undergo myogenic regeneration. Although myoblasts play a pivotal role in myogenic regeneration, their function is impaired with aging. MicroRNAs (miRNAs) are also involved in myogenic regeneration.
Kaori Shintani-Ishida, Riko Tsurumi, Hiroshi Ikegaya   +2 more
doaj   +1 more source

Schwann Cells Promote Myogenic Differentiation of Myoblasts and Adipogenic Mesenchymal Stromal Cells on Poly-ɛ-Caprolactone-Collagen I-Nanofibers

Cells, 2022
For the purpose of skeletal muscle tissue engineering, different cell types have been investigated regarding their myogenic differentiation potential, including co-cultured myoblasts and adipogenic mesenchymal stromal cells (Mb/ADSC).
Aijia Cai, Zeng-Ming Zheng, Marcus Himmler, Dirk W. Schubert, Thomas A. Fuchsluger, Volker Weisbach, Raymund E. Horch, Andreas Arkudas   +7 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Gene amplification during myogenic differentiation

Oncotarget, 2016
Gene amplifications are mostly an attribute of tumor cells and drug resistant cells. Recently, we provided evidence for gene amplifications during differentiation of human and mouse neural progenitor cells. Here, we report gene amplifications in differentiating mouse myoblasts (C2C12 cells) covering a period of 7 days including pre-fusion, fusion and ...
Fischer, Ulrike, Ludwig, Nicole, Raslan, Abdulrahman, Meier, Carola, Meese, Eckart   +4 more
openaire   +3 more sources

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation. [PDF]

, 2010
During myogenic differentiation the short mitochondria of myoblasts change into the extensively elongated network observed in myotubes. The functional relevance and the molecular mechanisms driving the formation of this mitochondrial network are unknown.
de Palma, Clara, Cipolat, S., Bassi, Maria Teresa, R. Allevi, C Panzeri, S Cipolat, Cossu, Giulio, Panzeri C, L. Scorrano, Pozzan, T., De Palma, C., S. Cipolat, T. Pozzan, Scorrano, L., M T Bassi, Cipolat, Sara, Pambianco S, Moncada, S., L Scorrano, Pisconti, A., Moncada S, G. Cossu, C. Panzeri, Cipolat S, Brunelli, S., Panzeri, Chris, Clementi E., G Cossu, Falcone S, Bassi MT, R Allevi, Clementi, Emilio, Pambianco, Sarah, C. De Palma, S Falcone, E Clementi, Allevi, Raffaele, Pisoni, Serena, Pisoni S, POZZAN, TULLIO, S. Pambianco, Falcone, S., S Moncada, Moncada, Salvador, Cossu G, S. Moncada, Pisconti, Addolorata, Brunelli, Silvia, S Brunelli, Pisoni, S., S Pambianco, Bassi, M. T., C De Palma, Allevi, R., S Pisoni, A Pisconti, Falcone, Sestina, T Pozzan, S. Pisoni, Brunelli S, Panzeri, C., Clementi, E., S. Brunelli, SCORRANO, LUCA, A. Pisconti, S. Falcone, M. T. Bassi, Allevi R, De Palma C, Pambianco, S., E. Clementi, Pisconti A, Cossu, G.   +72 more
core   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Tunable 3D‐Printed Static Mixers for Gradient Bioprinting With High Cell Viability

Advanced Materials Technologies, EarlyView.
ABSTRACT The fabrication of native tissue‐like structures with gradual transitions in material properties, cell types, and growth factors remains a major challenge in biofabrication due to the lack of suitable methods. Mimicking the hierarchical organization of living tissues is essential for functional models, yet creating gradient, multimaterial ...
Florian Hofmann, Jessica Faber, Franz Moser, Alessandro Cianciosi, Nicoletta Murenu, Joachim Schenk, Katrin G. Heinze, Natascha Schaefer, Silvia Budday, Tomasz Jungst   +9 more
wiley   +1 more source

Directing Myogenic Mesenchymal Stem Cell Differentiation [PDF]

Circulation Research, 2008
See related article, pages 635–642 Vascular smooth muscle cells (SMCs) play an important role in the embryonic and postnatal development and remodeling of blood vessels. In mature vasculature, SMCs regulate the vascular tone and, thereby, the blood pressure and blood distribution.
Peter E, Westerweel, Marianne C, Verhaar
openaire   +2 more sources

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source

Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation

Skeletal Muscle, 2011
Background Leukemia inhibitory factor (LIF) is known to inhibit myogenic differentiation as well as to inhibit apoptosis and caspase-3 activation in non-differentiating myoblasts.
Hunt Liam C, Upadhyay Aradhana, Jazayeri Jalal A, Tudor Elizabeth M, White Jason D   +4 more
doaj   +1 more source