Results 61 to 70 of about 64,746 (288)

Zeb2 Regulates Myogenic Differentiation in Pluripotent Stem Cells [PDF]

International Journal of Molecular Sciences, 2020
Skeletal muscle differentiation is triggered by a unique family of myogenic basic helix-loop-helix transcription factors, including MyoD, MRF-4, Myf-5, and Myogenin. These transcription factors bind promoters and distant regulatory regions, including E-box elements, of genes whose expression is restricted to muscle cells.
Ester Sara Di Filippo, Domiziana Costamagna, Giorgia Giacomazzi, Álvaro Cortés-Calabuig, Agata Stryjewska, Danny Huylebroeck, Stefania Fulle, Maurilio Sampaolesi   +7 more
openaire   +3 more sources

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]

, 2014
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y, Chooljian, Marc S, Conboy, Irina M, Cousin, Wendy, Elabd, Christian, Jiang, Kevin P, Kung, Sunny, Li, Ju, Upadhyayula, Pavan   +8 more
core   +1 more source

Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells [PDF]

In Vivo, 2018
Geranylgeraniol (GGOH) is a C20 isoprenoid found in fruits, vegetables, and grains, including rice. As a food substance, GGOH is categorized as 'Generally Recognized as Safe'. GGOH is an intermediate product in the mevalonate pathway and acts as a precursor to geranylgeranyl pyrophosphate.C2C12 mouse myoblasts derived from muscle satellite cells were ...
Takuma, Matsubara, Mariko, Urata, Tsuyoshi, Nakajima, Mari, Fukuzaki, Ryo, Masuda, Yoshiyuki, Yoshimoto, William N, Addison, Chihiro, Nakatomi, Kazmasa, Morikawa, Min, Zhang, Katsura, Saeki, Yukiko, Takahashi, Atsuko, Nakamichi, Shoichiro, Kokabu   +13 more
openaire   +2 more sources

The matricellular protein ADAMTS-like 2 regulates differentiation of skeletal muscle-resident fibro-adipogenic progenitor cells

iScience
Summary: Skeletal muscle development and regeneration requires the activities of myogenic and non-myogenic muscle stem cell populations. Non-myogenic muscle stem cells, such as fibro-adipogenic progenitors (FAPs), play important roles in muscle ...
Charlene Redhead, Nandaraj Taye, Britney Chin-Young, Kasoorelope Oguntuyo, James H. Cummins, Kevin J. Hart, Woojin M. Han, Dirk Hubmacher   +7 more
doaj   +1 more source

Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.

PLoS ONE, 2023
Muscles that are injured or atrophied by aging undergo myogenic regeneration. Although myoblasts play a pivotal role in myogenic regeneration, their function is impaired with aging. MicroRNAs (miRNAs) are also involved in myogenic regeneration.
Kaori Shintani-Ishida, Riko Tsurumi, Hiroshi Ikegaya   +2 more
doaj   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors

Cell Reports, 2018
Summary: Myogenic differentiation of human pluripotent stem cells (hPSCs) has been done by gene overexpression or directed differentiation. However, viral integration, long-term culture, and the presence of unwanted cells are the main obstacles. By using
Jianbo Wu, Nadine Matthias, Jonathan Lo, Jose L. Ortiz-Vitali, Annie W. Shieh, Sidney H. Wang, Radbod Darabi   +6 more
doaj   +1 more source

Schwann Cells Promote Myogenic Differentiation of Myoblasts and Adipogenic Mesenchymal Stromal Cells on Poly-ɛ-Caprolactone-Collagen I-Nanofibers

Cells, 2022
For the purpose of skeletal muscle tissue engineering, different cell types have been investigated regarding their myogenic differentiation potential, including co-cultured myoblasts and adipogenic mesenchymal stromal cells (Mb/ADSC).
Aijia Cai, Zeng-Ming Zheng, Marcus Himmler, Dirk W. Schubert, Thomas A. Fuchsluger, Volker Weisbach, Raymund E. Horch, Andreas Arkudas   +7 more
doaj   +1 more source

HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]

, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini, Chiara Noviello, Nicoletta Marroncelli, Sergio Adamo, Viviana Moresi, Viviana Moresi   +5 more
core   +3 more sources

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source