Results 71 to 80 of about 64,746 (288)

Engineering muscle networks in 3D gelatin methacryloyl hydrogels: influence of mechanical stiffness and geometrical confinement [PDF]

, 2017
In this work, the influence of mechanical stiffness and geometrical confinement on the 3D culture of myoblast-laden gelatin methacryloyl (GelMA) photo-crosslinkable hydrogels was evaluated in terms of in vitro myogenesis.
Barbetta, Andrea, Costantini, Marco, Fornetti, Ersilia, Gargioli, Cesare, Maria Cannata, Stefano, Rainer, Alberto, Testa, Stefano, Trombetta, Marcella   +7 more
core   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Biphenotypic Sinonasal Sarcoma-Case Report and Review of Clinicopathological Features and Diagnostic Modalities. [PDF]

, 2019
Background Biphenotypic sinonasal sarcoma is a recently described malignancy showing dual differentiation with both myogenic and neural elements. Due to its histologic similarities to other sinonasal malignancies, it is a diagnostic challenge.
Chitguppi, Chandala, Collura, Kaitlin, Curtis, Mark, Koszewski, Ian, Nyquist, Gurston G., Rabinowitz, Mindy R., Rosen, Marc   +6 more
core   +2 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]

, 2016
PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela, Lembo, Giuseppe, Perrotta, Marialuisa   +2 more
core   +2 more sources

Elastomeric Micro‐Balloons for Remote Control of Cerebral Blood Flow and Real‐Time In vivo Imaging of Rodent Brain Response to Hypoperfusion

Advanced Materials, EarlyView.
This study reports the fabrication of MRI‐compatible elastomeric micro‐balloons via a multi‐step bubble casting process, where the monolithic elastomeric wall is selectively stiffened for reversible and controlled inflation and elasticity, depending on the target vessels for graded occlusion of cerebral arteries.
Jong Bin Kim, Jinghui Wang, Yinding Chi, Jingxian Wu, Alicia Ng, Guanda Qiao, Honglin Tan, Miroslaw Janowski, Piotr Walczak, Yajie Liang, Shu Yang   +10 more
wiley   +1 more source

Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation

Skeletal Muscle, 2011
Background Leukemia inhibitory factor (LIF) is known to inhibit myogenic differentiation as well as to inhibit apoptosis and caspase-3 activation in non-differentiating myoblasts.
Hunt Liam C, Upadhyay Aradhana, Jazayeri Jalal A, Tudor Elizabeth M, White Jason D   +4 more
doaj   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]

, 2016
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena, Fernández-Chacón, Rafael, Gómez-Sánchez, Leonardo, Nieto González, José Luis, Rivero, María C, Servián Morilla, Emilia   +5 more
core   +1 more source

Hypoxia Inhibits Myogenic Differentiation through Accelerated MyoD Degradation [PDF]

Journal of Biological Chemistry, 2004
Cells undergo a variety of biological responses when placed in hypoxic conditions, including alterations in metabolic state and growth rate. Here we investigated the effect of hypoxia on the ability of myogenic cells to differentiate in culture. Exposure of myoblasts to hypoxia strongly inhibited multinucleated myotube formation and the expression of ...
A. Di Carlo, R. De Mori, F. Martelli, G. Pompilio, M. C. Capogrossi, A. Germani   +5 more
openaire   +2 more sources