Results 51 to 60 of about 64,746 (288)
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
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Molecular mechanisms regulating myogenic determination and differentiation [PDF]
Frontiers in Bioscience, 2000 The myogenic regulatory factors are necessary for the determination and terminal differentiation of skeletal muscle. Gene targeting experiments have demonstrated that MyoD and Myf5 are important for myogenic determination whereas myogenin and MRF4 are important for terminal differentiation and lineage maintenance. During development, all trunk skeletal
R L, Perry, M A, Rudnick
openaire +2 more sources
BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
Scientific Reports, 2017 Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure.
Thomas C. Roberts +7 more
doaj +1 more source
Inhibition of glycogen synthase kinase-3β attenuates glucocorticoid-induced suppression of myogenic differentiation in vitro. [PDF]
PLoS ONE, 2014 Glucocorticoids are the only therapy that has been demonstrated to alter the progress of Duchenne muscular dystrophy (DMD), the most common muscular dystrophy in children.
Zhenyu Ma +4 more
doaj +1 more source
Cells, 2022 Muscle injuries, degenerative diseases and other lesions negatively affect functioning of human skeletomuscular system and thus quality of life. Therefore, the investigation of molecular mechanisms, stimulating myogenic differentiation of primary ...
Rokas Mikšiūnas +2 more
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HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes [PDF]
, 2018 Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells to replicate and differentiate in response to appropriate stimuli. Epigenetic control is effective at different stages of this process.
Adamo, Sergio +9 more
core +2 more sources
Skeletal muscle: a significant novel neurohypophyseal hormone-secreting organ [PDF]
, 2019 Vasopressin (arg8-vasopressin) and oxytocin are closely relalated hormones, synthesized as pre-hormones in the magnocellular neurons of the paraventricular Q6 and supraoptic nuclei of the hypothalamus.
Dario Coletti +6 more
core +2 more sources
Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation [PDF]
Journal of Cancer, 2018 Covalent CDK7 inhibitor THZ1 is a newly discovered anti-tumor drug.THZ1 affects the function of transcription factor TFIIH by inhibiting CDK7, which in turn affects RNA polymerase II, and ultimately affects transcription initiation. Study found that THZ1 could inhibit proliferation and promote apoptosis of several tumor cell lines. However, there is no
Ma, Xinqi +11 more
openaire +2 more sources
SMAD2 Promotes Myogenin Expression and Terminal Myogenic Differentiation [PDF]
Development, 2020 ABSTRACTSMAD2 is a transcription factor whose activity is regulated by members of the Transforming Growth Factor beta (TGFβ) superfamily. While activation of SMAD2 and SMAD3 downstream of TGFβ or myostatin signaling is known to inhibit myogenesis, we find that SMAD2 in the absence of TGFβ signaling promotes terminal myogenic differentiation.
Émilie Lamarche +5 more
openaire +3 more sources
FEBS Open Bio, 2020 Thioredoxin (Trx) is a hydrogen acceptor of ribonucleotide reductase and a regulator of some enzymes and receptors. It has been previously shown that significantly elevated levels of Trx expression are associated with the osteogenic differentiation of ...
Meiling Liu +9 more
doaj +1 more source