Results 91 to 100 of about 117,263 (356)

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

Serum Myoglobin in Patients with Thyroid Dysfunction

Sultan Qaboos University Medical Journal, 2009
Objectives: To assess the pattern of change in serum myoglobin concentration in subjects with thyroid dysfunction. Methods: Serum samples were selected from 150 subjects with suspected thyroid disorder who were referred to the Royal Hospital, Muscat ...
Waad-Allah S Mula-Abed, Sawsan S Al-Sinani, Huda S Al-Hashmi   +2 more
doaj  

Myoglobin function reassessed [PDF]

Journal of Experimental Biology, 2003
SUMMARYThe heart and those striated muscles that contract for long periods, having available almost limitless oxygen, operate in sustained steady states of low sarcoplasmic oxygen pressure that resist change in response to changing muscle work or oxygen supply. Most of the oxygen pressure drop from the erythrocyte to the mitochondrion occurs across the
Beatrice A. Wittenberg, Jonathan B. Wittenberg   +1 more
openaire   +3 more sources

Predictive Value of Serum Myoglobin and Creatine Phosphokinase for Development of Acute Kidney Injury in Traumatic Rhabdomyolysis

Indian Journal of Critical Care Medicine, 2017
Introduction: Rhabdomyolysis (RM) is a condition where there is injury to striated muscle fibers causing release of myoglobin, creatine phosphokinase (CPK), and other intracellular contents into the circulation.
N. Raju, S. Rao, J. Joel, G. G. Jacob, Arun Kunnanchery Anil, S. Gowri, S. Kandasamy   +6 more
semanticscholar   +1 more source

FNIP-1 Expression in Mice Muscle Negatively Correlated with Myoglobin Level and Endurance Performance on Treadmill Run Test

Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación
Previously, FNIP-1 was found to play a critical role in the coupling of mitochondria function to restore ATP. Mitochondria was need to be supplied sufficient oxygen by myoglobin in the myocyte.
Dita Yuliastrid, Bambang Purwanto, Nining Widyah Kusnanik, Heni Yuli Handayani, Septyaningrum Putri Purwoto   +4 more
doaj   +1 more source

Development of a Novel Device for the Perfusion Driven Decellularization of Skeletal Muscle [PDF]

, 2014
Decellularization of skeletal muscle is a process that removes cellular components of skeletal muscle tissue while leaving behind the intact extracellular matrix (ECM).
Kasukonis, Benjamin
core   +2 more sources

Magnetic susceptibility anisotropy of myocardium imaged by cardiovascular magnetic resonance reflects the anisotropy of myocardial filament α-helix polypeptide bonds. [PDF]

, 2015
BackgroundA key component of evaluating myocardial tissue function is the assessment of myofiber organization and structure. Studies suggest that striated muscle fibers are magnetically anisotropic, which, if measurable in the heart, may provide a tool ...
Dibb, Russell, Liu, Chunlei, Qi, Yi
core   +1 more source

The mechanism of autooxidation of myoglobin.

Journal of Biological Chemistry, 1993
Time courses for the autooxidation of native and mutant sperm whale and pig myoglobins were measured at 37 degrees C in the presence of catalase and superoxide dismutase. In sperm whale myoglobin, His64(E7) was replaced with Gln, Gly, Ala, Val, Thr, Leu, and Phe; Val68(E11) was replaced with Ala, Ile, Leu, and Phe; Leu29(B10) was replaced with Ala, Val,
John S. Olson, Stephen J. Smerdon, Eileen W. Singleton, R E Brantley, Anthony J. Wilkinson   +4 more
openaire   +3 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Elevated plasma myoglobin level is closely associated with type 2 diabetic kidney disease

Journal of Diabetes
Background Diabetic kidney disease (DKD) is the most frequent complication in patients with type 2 diabetes mellitus (T2DM). It causes a chronic and progressive decline in kidney function, and ultimately patients require renal replacement therapy.
Lin Yang, Yan Shen, Wenxiao Li, Bingbing Zha, Wenjun Xu, Heyuan Ding   +5 more
doaj   +1 more source