Results 131 to 140 of about 8,085 (246)

MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Andrea D. Re Cecconi, Nicoletta Rizzi, Mara Barone, Federica Palo, Martina Lunardi, Mara Forti, Adriana Maggi, Paolo Ciana, Giulia Terribile, Michela Chiappa, Lorena Zentilin, Rosanna Piccirillo   +11 more
wiley   +1 more source

Gut microbiota and regulation of myokine-adipokine function

, 2020
Both skeletal muscle and adipose tissue are considered as endocrine organs due to their ability to produce and secrete several bioactive peptides (e.g. myokines and adipokines).
Suriano, Francesco, Van Hul, Matthias, Cani, Patrice D.   +2 more
core   +1 more source

Ageing‐Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Skeletal muscle is a postmitotic tissue dependent on a complex and tightly regulated regeneration process involving numerous intracellular and extracellular factors, including myogenic regulatory factors (MRFs), cytokines and myokines. Quiescent satellite cells are activated by physiological stimuli, injury or other traumatic insults for the ...
Geert M. de Vries, Willem De Ridder, Jonathan Baets   +2 more
wiley   +1 more source

RAGE Re‐Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia (CC) is a highly debilitating syndrome characterized by loss of body and muscle weight affecting most advanced cancer patients. The receptor for advanced glycation end‐products (RAGE) is expressed by several cell types and sustains the inflammatory response in acute and chronic diseases. Total ablation of RAGE (Ager−/
Sara Chiappalupi, Giulia Gentili, Laura Salvadori, Martina Paiella, Marcello Manfredi, Vittoria Federica Borrini, Kaamashri Mangar, Ann Marie Schmidt, Maurizio Muscaritoli, Francesca Riuzzi, Guglielmo Sorci   +10 more
wiley   +1 more source

Myokines in alcoholic myopathy

Journal of Contemporary Medical Sciences, 2015
Objective Interleukin (IL)-15 is highly expressed in skeletal muscles, where it exerts anabolic effects, increase protein content in muscle fibres and promotes muscle growth. Alcoholics frequently suffer myopathy. Therefore, we analyse the level of IL-15 [and other myokines, such as tumor necrosis factor-α (TNF-α)] in alcoholics.
Kammela Hadi Shammam, Fadhil Jawad Al-Tu’ma, Hedef Dafer El-Yassin   +2 more
openaire   +1 more source

Parsing cause from consequence in blood flow restriction training: Insights from integrated human physiology

The Journal of Physiology, EarlyView.
Coral L. Murrant
wiley   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease

, 2017
Yukari Sugiyama, Kazuhisa Asai, Kazuhiro Yamada, Yuko Kureya, Naoki Ijiri, Tetsuya Watanabe, Hiroshi Kanazawa, Kazuto Hirata Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan Background: Cigarette ...
Hirata K, Watanabe T, Asai K, Ijiri N, Sugiyama Y, Yamada K, Kureya Y, Kanazawa H   +7 more
core  

Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

, 2019
Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible ...
George-Emmanuel Maalouf, Diala El Khoury
core   +1 more source

Differences in the Impact of Various Types of Exercise on Irisin Levels: A Systematic Review and Meta-Analysis

International Journal of Preventive Medicine
Background: Irisin, a myokine that is responsive to exercise, induces significant changes in subcutaneous adipose tissue. By promoting the browning of white fat tissue, it enhances energy expenditure, thereby addressing overweight and obesity.
Atefe Torabi, Jalil Reisi, Mehdi Kargarfard, Marjan Mansourian   +3 more
doaj   +1 more source