Orthopaedic Surgery, Volume 18, Issue 9, Page 1785-1803, September 2026.This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu +4 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 9, Page 4179-4194, 1 September 2026.Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti +6 more
wiley +1 more source
Treating age‐related loss of muscle mass and function: Where should we be focusing?
The Journal of Physiology, Volume 604, Issue 17, Page 7059-7075, 1 September 2026.Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham +4 more
wiley +1 more source
Musculoskeletal and physiological responses to vortex wave stimulation in older adults
The Journal of Physiology, Volume 604, Issue 17, Page 7264-7286, 1 September 2026.Abstract figure legend We explored the acute physiological effects of a novel mechanical stimulus, vortex wave stimulation (VWS), in healthy older adults. Using deuterated water and serial skeletal muscle biopsies, we showed that VWS elevated integrated rates of myofibrillar, but not sarcoplasmic muscle protein synthesis, with no changes observed in ...
Alexander Waddell +7 more
wiley +1 more source
Development of Soft Substrate-Based In Vitro Muscle Models for Myokine Therapeutic Studies
Though exercise is known to reduce the risks of various diseases, the underlying mechanism is largely unknown. In the last few decades, researchers have identified protein factors secreted by contracting skeletal muscle, termed myokines, that exert ...
Sheng, Christina Y.
core
Myokine-mediated mechanisms of immune checkpoint inhibitors-associated colorectal injury and repair in rectal cancer. [PDF]
Front ImmunolMa S +6 more
europepmc +1 more source
Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review). [PDF]
Int J Mol MedTian B, Chen X, Zheng J, Kang X.
europepmc +1 more source
The Systemic Myokine Response to an Acute Bout of Blood Flow Restricted Exercise
, 2017 Blood flow restricted resistance training (BFR-RT) is an emerging hypertrophy training modality. A complete profile of its mechanisms of action has yet to be elucidated. Cytokines are universal intercellular messengers.
Bugera, Eric M.
core
The Myokine Adaptome in Health and Disease: Exercise-Induced Cellular Signaling, Muscle-Organ Crosstalk, and Therapeutic Plasticity. [PDF]
CellsMănescu DC +5 more
europepmc +1 more source
Muscle-Tumor Crosstalk in Exercise Oncology: Exercise-Induced Myokines and Cancer Cachexia. [PDF]
Cancers (Basel)Ahmadi Hekmatikar A +5 more
europepmc +1 more source