Results 121 to 130 of about 8,845 (203)

Exercise‐Induced Myonectin Protects Against Cerebral Ischemia–Reperfusion Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Exercise‐induced myonectin protects against cerebral ischemia–reperfusion injury. Myonectin knockout abolishes exercise benefits, whereas recombinant administration reduces cerebral infarct size. Mechanistically, myonectin activates PI3K/AKT/mTOR signaling, thereby suppressing excessive neuronal autophagy and microglial‐driven neuroinflammation ...
Jing Zhang, Shengle Chen, Jingyu Liu, Xin Qi, Xiaoming Zhang, Peng Lin, Dezhang Huang, Jing Li   +7 more
wiley   +1 more source

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

Drug Design, Development and Therapy, 2016
Shouta Miyatake,1 Yuko Shimizu-Motohashi,2 Shin’ichi Takeda,1 Yoshitsugu Aoki1 1Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; 2Department of Child Neurology,
Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y   +3 more
doaj  

Serum Bone‐, Muscle‐ and Fat‐ Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. Materials and Methods This study included 26 men with normal weight and 78 men with obesity.
Xiang Chen, Sumin Shen, Mingxi Zou, Zhenlin Zhang, Nanwei Tong, Juan Li   +5 more
wiley   +1 more source

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

Frontiers in Molecular Neuroscience
The initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality of life of patients, concurrently exerting a considerable strain on both the economy and the social ...
Xuepeng Bian, Qian Wang, Yibing Wang, Shujie Lou   +3 more
doaj   +1 more source

Touch Restriction Versus Free‐Play Small‐Sided Games in Soccer: Acute Effects on Serum BDNF, Executive Function, and Technical Actions

European Journal of Sport Science, Volume 26, Issue 9, September 2026.
ABSTRACT This study aimed to compare the acute effects of two 4v4 small‐sided game (SSG) formats, touch‐restricted SSG (SSGt) and free‐play SSG (SSGf), on serum brain‐derived neurotrophic factor (BDNF) levels, cognitive performance, and technical actions in young male soccer players. Thirty‐two young male soccer players completed two 4v4 SSG conditions
Yakup Zühtü Birinci, Serkan Pancar, Yusuf Soylu, Emre Sarandöl, Hasan Şimşek, Şenay Şahin, Michael C. Rumpf   +6 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Alterations in the Myokine Concentrations in Relation to Sarcopenia and Sleep Disturbances: A Narrative Review

Objectives: In this study, our aim is to summarise the available data on the correlation between sarcopenia and sleep disturbances as a consequence of changes in the myokine concentrations. Methods: Our research was conducted by searching through PubMed,
Michalina Knapik, Łukasz Jaśkiewicz, Jakub Kuna, Grzegorz Chmielewski, Magdalena Krajewska-Włodarczyk   +4 more
core   +1 more source

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

Reviews in Cardiovascular Medicine
Myokines are a group of cytokines or polypeptides released from skeletal muscle during exercise. Growing evidence suggests that myokines are associated with the development of cardiovascular disease (CVD).
Jin-xiu Lyu, Dan-dan Guo, Yu-chen Song, Man-ru Zhang, Feng-qin Ge, Jing Zhao, Hua Zhu, Peng-zhou Hang   +7 more
doaj   +1 more source

The Health Benefits of Exercise: Molecular and Cellular Mechanisms

MedComm, Volume 7, Issue 9, September 2026.
Our synthesis integrates evidence on exercise‐induced regulatory mechanisms across multiple systems (musculoskeletal, cardiovascular, nervous, metabolic and immune), cross‐system, and aging. We also discusses adaptive regulation of exercise in extreme environments, along with the prospects and challenges of multiomics and AI‐driven precision exercise ...
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling   +12 more
wiley   +1 more source

A Biomimetic 3D Human Skeletal Muscle Microtissue for Modeling Biological and Functional Hallmarks of Aging

Small Science, Volume 6, Issue 9, September 2026.
A biomimetic 3D human skeletal muscle microtissue platform is developed by integrating primary young and aged SkMCs with muscle‐derived dECM and 3D‐printed PCL anchors. Aged constructs recapitulate selected biological and functional hallmarks of skeletal muscle aging, including impaired myotube formation, mitochondrial alterations, calcium handling ...
Sohae Yang, Jeong Sik Kong, Hyun Young Shin, Sung Chun Cho, Aseer Intisar, Min Young Kim, Yeong‐Jin Choi, Yun‐Il Lee, Dong‐Woo Cho, Minseok S. Kim   +9 more
wiley   +1 more source