Results 121 to 130 of about 11,761 (240)

Exercise-Induced Irisin and Its Role in Metabolic and Neurological Adaptations: A Narrative Review

Quality in Sport
Background. In the context of the increasing prevalence of metabolic and neurodegenerative disorders, growing attention has been directed toward biological factors mediating the beneficial effects of physical activity.
Julia Anna Malec, Lidia Kulig, Zuzanna Winiarska, Weronika Maria Woźniak, Marcin Wieleba, Barbara Izabela Krupska, Magdalena Zapalska, Sara Steć, Eliza Wiercioch, Franciszek Włodarczyk   +9 more
doaj   +1 more source

Can irisin be a linker between physical activity and brain function?

Biomolecular Concepts, 2016
Irisin was initially discovered as a novel hormone-like myokine released from skeletal muscle during exercise to improve obesity and glucose dysfunction by stimulating the browning of white adipose tissue.
Zhang Jing, Zhang Weizhen
doaj   +1 more source

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

Exercise-Induced Changes in Circulating Exerkines Associated with Brain Health: A Systematic Review and Meta-Analysis in Healthy Populations

Sci
Exerkines are released in response to physical exercise and play a key role in promoting health, such as taking part in modulating brain morphology and function.
Songxin Tang, Raquel Pedrero-Chamizo, Eva Gesteiro, Carlos Quesada-González, Margarita Pérez-Ruiz, Marcela González-Gross   +5 more
doaj   +1 more source

The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis

Aging Cell, Volume 25, Issue 5, May 2026.
We provide the first human evidence that the exercise‐induced myokine irisin mediates the relationship between physical activity and hippocampal volume in older adults, with strongest effects in CA1, CA3 and CA4 subfields. These regions are critical for memory and particularly vulnerable to Alzheimer's disease.
Thomas Pace, Jacob M. Levenstein, Bonnie L. Quigley, Rhys Houston, Ana P. Bouças, Sophie C. Andrews   +5 more
wiley   +1 more source

Myokines and interorgan crosstalk: bridging exercise to health promotion and disease prevention [PDF]

Annals of Pediatric Endocrinology & Metabolism
Exercise is known to promote physical health and reduce the risk of various diseases. During exercise, skeletal muscle actively contracts to perform movements and secretes hormone-like molecules termed myokines.
Junseo Ha, Suchan Sung, Hyeonwoo Kim
doaj   +1 more source

New insights about the putative role of myokines in the context of cardiac rehabilitation and secondary cardiovascular prevention. [PDF]

, 2017
Exercise training prevents the onset and the development of many chronic diseases, acting as an effective tool both for primary and for secondary prevention.
Di Raimondo D, Miceli G, Musiari G, Pinto A., Tuttolomondo A   +4 more
core   +1 more source

UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia

Aging Cell, Volume 25, Issue 5, May 2026.
Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima, Taiga Nagamune, Saori Tada, Daiki Watanabe, Nao Tokuda, Takashi Yamada, Akiko Hashimoto‐Hachiya, Sayaka Higo‐Yamamoto, Kohei Kido, Noriyuki Nagaoka, Aoi Ikedo, Yuuki Imai, Ryo Fujita, Seiya Mizuno, Satoru Takahashi, Katsutaka Oishi, Satoru Ato, Riki Ogasawara   +17 more
wiley   +1 more source

Interleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis

Frontiers in Immunology
PurposeInterlukin-15 (IL-15) is an inflammatory cytokine that plays a vital role in immunology and obesity-associated metabolic syndrome. We performed this systematic review and meta-analysis to investigate whether exercise promotes circulating IL-15 ...
Mousa Khalafi, Aref Habibi Maleki, Michael E. Symonds, Mohammad Hossein Sakhaei, Sara K. Rosenkranz, Mahsa Ehsanifar, Mallikarjuna Korivi, Yubo Liu   +7 more
doaj   +1 more source