Results 101 to 110 of about 8,845 (203)

Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion

, 2019
Myokines are peptides known to modulate brain neuroplasticity, adipocyte metabolism, bone mineralization, endothelium repair and cell growth arrest in colon and breast cancer, among other processes.
Pareja-Galeano, Helios, Romero-Morales C., Maffulli, Nicola, Sanchis-Gomar F., Romero Morales, Carlos, Lopez-Lopez, Sergio, Lippi, Giuseppe, Sanchis-Gomar, Fabian, Lopez-Lopez S., Romero-Morales, Carlos, Pareja-Galeano H., Maffulli N., Lippi G., Pareja Galeano, Helios, López López, Sergio   +14 more
core   +1 more source

Skeletal Muscle–Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle injuries significantly impair mobility and function, yet effective therapeutic interventions remain limited. Both eccentric exercise (EE) and concentric exercise (CE) promote muscle repair, but the underlying mechanisms are not fully understood.
Yining Zhou, Xiaoyan Shao, Pan Zhang, Jiaquan Lin, Xiang Chen, Xueying An, Zhuoying Jiang, Haosheng Wang, Depeng Fang, Yansi Xian, Bin Liu, Tao Shen, Ying Chen, Keran Li, Hongpeng Liu, Ying Li, Qing Jiang, Baosheng Guo   +17 more
wiley   +1 more source

Myokine Secretion Dynamics and Their Role in Critically Ill Patients: A Scoping Review

Background/Objectives: Myokines can modulate organ function and metabolism, offering a protective profile against ICU complications beyond preventing local muscle wasting.
Jalil Contreras, Yorschua Frederick, Gutiérrez Arias, Ruvistay, García Valdés, Patricio, Basoalto Escobar, Roque Ignacio, Gallastegui Guajardo, Julen Manuel, Patricio García-Valdés, Yorschua Jalil, Julen Gallastegui, Damiani Rebolledo, L. Felipe, L. Felipe Damiani, Ruvistay Gutierrez-Arias, Roque Basoalto   +11 more
core   +1 more source

MYOKINE PROBDNF-P75NTR SIGNALING IN SKELETAL MUSCLE INJURY AND STERILE INFLAMMATION [PDF]

Originally discovered in the brain, brain-derived neurotrophic factor (BDNF) has been shown to be expressed and released from skeletal muscle as a myokine. However, the function of myokine BDNF is not fully understood.
Aby, Katherine
core   +1 more source

Hydrogen Sulfide and Irisin, Potential Allies in Ensuring Cardiovascular Health

Antioxidants
Irisin is a myokine secreted under the influence of physical activity and exposure to low temperatures and through different exogenous stimuli by the cleavage of its precursor, fibronectin type III domain-containing protein 5 (FNDC5).
Lorenzo Flori, Giada Benedetti, Vincenzo Calderone, Lara Testai   +3 more
doaj   +1 more source

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in
Jeremy B. Ducharme, Martin M. Schonk, Miguel A. Gutierrez‐Monreal, Leonardo F. Ferreira, Karyn A. Esser, Andrew R. Judge, Sarah M. Judge   +6 more
wiley   +1 more source

Effects of Daily Rhythm‐Aligned Training on Skeletal Muscle Adaptation in Older Adults: A Randomized Controlled Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Ageing is associated with declines in skeletal muscle mass and strength, increasing the risk of sarcopenia, functional impairment and reduced quality of life. Resistance training is an effective intervention to counteract these changes.
Fabienne Bruggisser, Soraya Ritter, Ralf Roth, Egbert T. Ritter, Denis Infanger, Romina Ledergerber, Timo Hinrichs, Frank A. J. L. Scheer, Christoph Handschin, Henner Hanssen, Raphael Knaier   +10 more
wiley   +1 more source

Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease

, 2017
Yukari Sugiyama, Kazuhisa Asai, Kazuhiro Yamada, Yuko Kureya, Naoki Ijiri, Tetsuya Watanabe, Hiroshi Kanazawa, Kazuto Hirata Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan Background: Cigarette ...
Hirata K, Watanabe T, Asai K, Ijiri N, Sugiyama Y, Yamada K, Kureya Y, Kanazawa H   +7 more
core  

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Myokine Irisin and Its Effects Linking Bone and Muscle Function

, 2018
Irisin is a myokine secreted by the skeletal muscle during physical activity both in mice and humans. Its first identified role was to activate the browning response in white adipocytes, subsequently triggering non-shivering thermogenesis; therefore ...
Giacomina Brunetti, Silvia C. Colucci, Colucci, Silvia C., Colaianni, Graziana, Brunetti, Giacomina, Grano, Maria, Maria Grano, Graziana Colaianni   +7 more
core   +1 more source