Results 81 to 90 of about 11,761 (240)

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review [PDF]

, 2017
Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator ...
Dinas, Petros C., Flouris, Andreas D., Koutedakis, Yiannis, Lahart, Ian, Metsios, George S., Svensson, Per-Arne, Timmons, James A.   +6 more
core   +2 more sources

Myokines: Crosstalk and Consequences on Liver Physiopathology

Nutrients, 2023
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease mainly characterized by the hepatic accumulation of lipid inducing a deregulation of β-oxidation. Its advanced form is non-alcoholic steatohepatitis (NASH), which, in addition to lipid accumulation, induces hepatocellular damage, oxidative stress and fibrosis that can progress to ...
Aurore Dumond Bourie, Jean-Baptiste Potier, Michel Pinget, Karim Bouzakri   +3 more
openaire   +2 more sources

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer [PDF]

, 2019
Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism.
Adler, Andreas, Aigner, Felix, Becker, Olaf, Biebl, Matthias, Bosma, Madeleen, Pratschke, Johann, Quint, Janina, Spitz, Wolfgang, Stockmann, Martin, Veltzke-Schlieker, Wilfried, Weiss, Sascha, Wizenty, Jonas, Wuensch, Tilo   +12 more
core   +2 more sources

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle [PDF]

, 2016
[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function.
Cordido, Fernando, Juiz-Valiña, Paula, Pena-Bello, Lara, Sangiao-Alvarellos, Susana, Varela-Rodríguez, Bárbara María, Vidal Bretal, Beatriz   +5 more
core   +2 more sources

Clinical trials and Myokines [PDF]

, 2014
Background: Cardiovascular disease is a major cause of death in the western world. Regular physical activity is known to be highly beneficial for improving cardiovascular health status. Methods:The current abstract is based on the authors own data and a literature review. The authors own studies have all been accepted by the local ethics committee.
openaire   +1 more source

Therapiefaktor Myokine – Des Muskels Botenstoff [PDF]

physiopraxis, 2017
Myokine sind Botenstoffe, die der Korper vermehrt bei intensiver Muskelbeanspruchung ausschuttet. Sie stoppen beispielsweise Entzundungen und regulieren die Immunabwehr. Seit 2007 werden immer mehr Details bekannt, wie Muskelarbeit konkret den Fett- und Zuckerstoffwechsel beeinflusst.
openaire   +1 more source

Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin

Journal of Periodontal Research, EarlyView.
Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non‐communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or ...
Larysa Saboya Cavalotti Perdonsini, Rafael Scaf de Molon, Søren Jepsen, Iain Chapple, Joao Paulo Steffens   +4 more
wiley   +1 more source

Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health

Nutrients
Obesity and osteoarthritis (OA) are increasingly prevalent conditions that are intricately linked, with each exacerbating the other’s pathogenesis and worsening patient outcomes. This review explores the dual impact of obesity on OA, highlighting the role of excessive weight in aggravating joint degeneration and the limitations OA imposes on physical ...
Daniel Vasile Timofte, Razvan Cosmin Tudor, Veronica Mocanu, Luminita Labusca   +3 more
openaire   +2 more sources