Results 71 to 80 of about 11,761 (240)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Administration of Interleukin-15 Peptide Improves Cardiac Function in a Mouse Model of Myocardial Infarction. [PDF]

, 2020
Interleukin-15 is a pleotropic factor, capable of modulating metabolism, survival, proliferation, and differentiation in many different cell types.
Ameri, Kurosh, Bayardorj, Dulguun, Fredkin, Maxwell, Fuh, Eric, Nguyen, Vien, Samurkashian, Raffi, Yeghiazarians, Yerem   +6 more
core  

Exercise-induced ‘browning’ of adipose tissues [PDF]

, 2017
Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocytes ...
Albrecht, Antonopoulos, Arner, Barreau, Berry, Bloor, Bogardus, Bordbar, Bostrom, Cannon, Carriere, Chaudhuri, Coelho, Craig Sale, Cypess, de Jong, De Matteis, Despres, Despres, Despres, Disanzo, DiSpirito, During, Emre, Fischer, Follenius, Fromme, Gagnon, Giralt, Haczeyni, Helen Budge, Hetzler, James Betts, Jespersen, Joyner, Kammoun, Kazak, Knudsen, Larue-Achagiotis, Liu, Long, M, Ma, Magkos, Maloney, Margaritis, Mark Pope, Marker, Matsushita, Michael E. Symonds, Nakhuda, Nielsen, Nozu, Oelkrug, Ostrowski, Palmer, Patsouris, Peppler, Peter Aldiss, Powers, Rao, Razzoli, Robciuc, Ronn, Sacks, Sanchez-Gurmaches, Scheele, Schreiber, Scott, Sengenes, Sepa-Kishi, Shabalina, Shimizu, Shin, Sidossis, Singhal, Stanford, Takx, Thomas, Thompson, Trayhurn, Tsiloulis, Tsoli, van Marken Lichtenbelt, Vergnes, Vieira, Virtanen, Vosselman, Woods, Wu, Wu, Yamashita, Yoneshiro   +92 more
core   +3 more sources

Symposium 10: Myokines

Revista de la Sociedad Argentina de Diabetes, 2022
Skeletal muscle (SM) is not only a locomotor unit responsible for the propulsion and regulation of energy and metabolic processes. Now it is also recognized as an organ capable of producing molecules with vital functions: the so-called myokines1. Over the past two decades, it has become apparent that the ME functions as an endocrine organ in response ...
openaire   +1 more source

Adipokines, Myokines and Cardiovascular Disease

Circulation Journal, 2009
It is recognized that obesity contributes to cardiovascular and metabolic disorders through alterations in the levels of adipocyte-derived cytokines (adipokines). Adiponectin is an adipokine that is downregulated in obese individuals. It has beneficial actions on the cardiovascular system by directly acting on the heart and blood vessels, and acute ...
openaire   +3 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source

The Role of Fibroblast Growth Factor 19 Subfamily in Different Populations Suffering From Osteoporosis

Frontiers in Endocrinology, 2022
Fibroblast growth factor (FGF) 19 subfamily, also known as endocrine fibroblast growth factors (FGFs), is a newly discovered metabolic regulator, including FGF19, FGF21 and FGF23.
Xiawen Yu, Yue Xia, Jue Jia, Guoyue Yuan
doaj   +1 more source

Releasing The Anti-inflammatory Potential of Paralysed Skeletal Muscle: The Circulating Cytokine Response to Voluntary Upper-limb Exercise With/Without The Addition of Functional Electrical Stimulation (FES)-evoked Lower-limb Contractions [PDF]

, 2013
Skeletal muscle is a rich store of inflammatory mediating ‘myokines’. Following release from contracting muscle, the myokine interleukin-6 (IL-6) promotes a circulating anti-inflammatory environment associated with a reduced risk of cardiovascular ...
Bishop, Nicolette C, Goosey-Tolfrey, Victoria L, Paulson, Thomas AW, Smith, Brett M   +3 more
core   +1 more source