Results 61 to 70 of about 8,845 (203)

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism [PDF]

, 2023
No longer viewed as a metabolic waste product and cause of muscle fatigue, a contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in normal as well as pathophysiological conditions.
Brooks, George A, Moreno-Santillan, Diana D, Osmond, Adam D, Duong, Justin J, Leija, Robert G, Arevalo, Jose A, Curl, Casey C   +6 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling [PDF]

, 2023
A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown.
Galvão, Daniel A., Taaffe, Dennis R., Newton, Robert U., Dennis R. Taaffe, Jin-Soo Kim, Fred Saad, Kim, Jin-Soo, Saad, Fred, Daniel A. Galvão, Robert U. Newton   +9 more
core   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Association between GLIM‐defined malnutrition and in‐hospital costs in adults with sepsis: A sub analysis of a prospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background International statements suggest using the Global Leadership Initiative on Malnutrition (GLIM) criteria in intensive care units (ICUs); however, the economic impact of GLIM‐defined malnutrition in sepsis remains unclear. This study investigated the association between GLIM‐defined malnutrition and in‐hospital costs in sepsis ...
Yuki Hashimoto, Minoru Yoshida, Tomoka Miyagi, Akane Kariya, Hitomi Tanoue, Naoki Kanda, Yusuke Hoshi, Takahiro Fujita, Kensei Togo, Tomoaki Obata, Kenzo Ishii, Katsuyuki Abe, Chihiro Sato, Yoshifumi Heshiki, Daisetsu Yasumura, Shizuko Gomi, Masafumi Takahashi, Takashi Hongo, Keiji Sakurai, Miho Nishihara, Yuko Matsuda, Kiyota Chinen, Akiko Arai, Michihiro Maeda, Yuhei Irie, Hiroshi Kamijo, Kana Hosokawa, Daisuke Kasugai, Michiko Higashi, Ayaka Matsuoka, Hirotaka Ogawa, Yuichi Araki, Kenji Oike, Daigo Shimakura, Hajime Katsukawa, Toru Kotani, Takayuki Ogura, Keibun Liu, Kensuke Nakamura   +38 more
wiley   +1 more source

Aberrant Myokine Signaling in Congenital Myotonic Dystrophy

, 2017
Summary: Myotonic dystrophy types 1 (DM1) and 2 (DM2) are dominantly inherited neuromuscular disorders caused by a toxic gain of function of expanded CUG and CCUG repeats, respectively.
Yukiko K. Hayashi, Masayuki Nakamori, Hideki Mochizuki, Kohei Hamanaka, Ichizo Nishino, Eric T. Wang, Masanori P. Takahashi, Maurice S. Swanson, James D. Thomas   +8 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Advances in the Protective Effects and Mechanisms of β‐Aminoisobutyric Acid in Maintaining Multi‐Organ Homeostasis

Medicine Bulletin, EarlyView.
ABSTRACT β‐Aminoisobutyric acid (BAIBA) is an exercise‐responsive myokine/metabolite released by skeletal muscle and has attracted increasing interest as a potential exercise mimetic and therapeutic candidate in preclinical research. BAIBA acts locally in skeletal muscle and can also reach distal organs through the circulation, contributing to the ...
Hao‐Zhe Wang, Wen‐Bi He, Fei‐Peng Chen, Jiong‐Xing Huang, Lin Zhu, Xiao‐Guang Liu   +5 more
wiley   +1 more source