Results 61 to 70 of about 8,085 (246)

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Physical Exercise Inhibits Inflammation and Microglial Activation

Cells, 2019
Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems
Onanong Mee-inta, Zi-Wei Zhao, Yu-Min Kuo   +2 more
doaj   +1 more source

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

Metabolites, 2023
Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia.
Hajnalka Lőrincz, Sándor Somodi, Balázs Ratku, Mariann Harangi, György Paragh   +4 more
doaj   +1 more source

Metabolic Health—The Role of Adipo-Myokines [PDF]

International Journal of Molecular Sciences, 2019
Obesity is now a worldwide epidemic. In recent years, different phenotypes of obesity, ranging from metabolically healthy normal weight to metabolically unhealthy obese, were described. Although there is no standardized definition for these phenotypes or for metabolic health, the influence of lifestyle and early-life factors is undisputed.
Graf, Christine, Ferrari, Nina
openaire   +2 more sources

Muscle–Organ Crosstalk: The Emerging Roles of Myokines [PDF]

Endocrine Reviews, 2020
Abstract Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can ...
Mai Charlotte Krogh Severinsen, Bente Klarlund Pedersen   +1 more
openaire   +3 more sources

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation

, 2016
© 2015 by the American College of Sports Medicine. Purpose Myokines have been shown to affect muscle physiology and exert systemic effects. We endeavored to investigate a panel of myokine mRNA expression after a single exercise bout (studies 1 and 2) to ...
Galgani, Jose E., Redman, Leanne M., Tam, Charmaine S, Galgani Fuentes, José, Ravussin, E., Smith, Steven R, Noland, Robert C., Galgani, Jose E, Covington, J., Redman, Leanne M, Smith, Steven R., Smith, S., Covington, Jeffrey D., Noland, R., Bajpeyi, S., Noland, Robert C, Redman, L., Bajpeyi, Sudip, Tam, C., Covington, Jeffrey D, Ravussin, Eric, Tam, Charmaine S.   +21 more
core   +1 more source

Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

Frontiers in Physiology, 2023
The detrimental impact of obesity on human health is increasingly evident with the rise in obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance metabolism, plays a significant role as a secretory organ by releasing ...
Weimin Lin, Hongbin Song, Jieqiong Shen, Jing Wang, Yue Yang, Yinhua Yang, Jiacheng Cao, Li’e Xue, Fanglu Zhao, Tianfang Xiao, Ruiyi Lin   +10 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

, 2021
Recent evidence indicates that skeletal muscle influences systemic aging but little is known on the signaling pathways and muscle-released cytokines (myokines) responsible for this inter-tissue communication.
Demontis, Fabio, Swindell, William R., Perrimon, Norbert, Patel, Vishal K.   +3 more
core   +2 more sources