Results 41 to 50 of about 8,845 (203)

A low-calorie diet raises β-aminoisobutyric acid in relation to glucose regulation and leptin independent of exercise in women with obesity

Frontiers in Physiology, 2023
Introduction: β-aminoisobutyric acid (BAIBA) is a suggested cytokine secreted from skeletal muscles that regulates insulin sensitivity, pancreatic function, and fat oxidation. However, no studies to date have examined if a low-calorie diet (LCD) or LCD +
Habiba Faiz, Steven K. Malin, Steven K. Malin, Steven K. Malin, Steven K. Malin, Steven K. Malin   +5 more
doaj   +1 more source

Crosstalk Between Muscle and Bone Via the Muscle-Myokine Irisin

, 2016
Several lines of evidence have recently established that skeletal muscle is an endocrine organ producing and releasing myokines acting in a paracrine or endocrine fashion.
GRANO, Maria, Mongelli, T., Colucci, S., MONGELLI, TERESA, Colaianni, G., COLAIANNI, GRAZIANA, COLUCCI, Silvia Concetta, Cinti, S., CINTI, Saverio   +8 more
core   +1 more source

Irisin levels are not affected by physical activity in patients with anorexia nervosa

Frontiers in Endocrinology, 2014
Irisin was recently identified as muscle-derived hormone that increases energy expenditure. Studies in normal weight and obese subjects reported an increased irisin expression following physical activity, although inconsistent results were observed ...
Tobias eHofmann, Ulf eElbelt, Ulf eElbelt, Anne eAhnis, Peter eKobelt, Matthias eRose, Andreas eStengel   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A preliminary study on the role of Piezo1 channels in myokine release from cultured mouse myotubes [PDF]

, 2022
It has long been known that regular physical exercise induces short and long term benefits reducing the risk of cardiovascular disease, diabetes, osteoporosis, cancer and improves sleep quality, cognitive level, mobility, autonomy in enderly.
Paola Zacchi, Annalisa Bernareggi, Federica Tramer, Marina Sciancalepore, Paola Lorenzon, Gabriele Massaria   +5 more
core   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Physical Exercise Inhibits Inflammation and Microglial Activation

Cells, 2019
Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems
Onanong Mee-inta, Zi-Wei Zhao, Yu-Min Kuo   +2 more
doaj   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

The myokine irisin increases cortical bone mass [PDF]

, 2015
It is unclear how physical activity stimulates new bone synthesis. We explored whether irisin, a newly discovered myokine released upon physical activity, displays anabolic actions on the skeleton.
Reseland, Janne E, DI COMITE, Mariasevera, Mongelli, T, Liu, P, COLAIANNI, GRAZIANA, Cinti, Saverio, Brunetti, G, Sartini, Loris, Grano, M., New, Mi, GRANO, Maria, CUSCITO, CONCETTA, Sun, Li, Zaidi, Mone, Pignataro, P, Liu, Peng, MORI, GIORGIO, Di Comite, M, Buccoliero, C, Mori, G, COLUCCI, Silvia Concetta, Pignataro, Paolo, Yuen, T, Sun, L, Yuen, Tony, New, Maria I, Colucci, Silvia, Zaidi, M, Lu, P, MONGELLI, TERESA, BUCCOLIERO, CINZIA, DI BENEDETTO, ADRIANA, Reseland, Je, Colucci, S, BRUNETTI, GIACOMINA, Di Benedetto, A, Lu, Ping, Colaianni, G, Cuscito, C   +38 more
core   +2 more sources

Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology

Frontiers in Physiology, 2021
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes.
Hyun-Kyung So, Hyun-Kyung So, Sunghee Kim, Jong-Sun Kang, Sang-Jin Lee   +4 more
doaj   +1 more source