Results 51 to 60 of about 8,085 (246)

A preliminary study on the role of Piezo1 channels in myokine release from cultured mouse myotubes [PDF]

, 2022
It has long been known that regular physical exercise induces short and long term benefits reducing the risk of cardiovascular disease, diabetes, osteoporosis, cancer and improves sleep quality, cognitive level, mobility, autonomy in enderly.
Paola Zacchi, Annalisa Bernareggi, Federica Tramer, Marina Sciancalepore, Paola Lorenzon, Gabriele Massaria   +5 more
core   +1 more source

Myokines in metabolic homeostasis and diabetes [PDF]

Diabetologia, 2019
Physical activity exerts multiple beneficial effects and the myokine concept provides a framework for understanding the molecular pathways that integrate contracting muscle in the complex network of organ communication. This network includes multiple distinct and distal organs; however, the autocrine and paracrine effects of myokines within skeletal ...
openaire   +2 more sources

Crosstalk Between Muscle and Bone Via the Muscle-Myokine Irisin

, 2016
Several lines of evidence have recently established that skeletal muscle is an endocrine organ producing and releasing myokines acting in a paracrine or endocrine fashion.
GRANO, Maria, Mongelli, T., Colucci, S., MONGELLI, TERESA, Colaianni, G., COLAIANNI, GRAZIANA, COLUCCI, Silvia Concetta, Cinti, S., CINTI, Saverio   +8 more
core   +1 more source

The myokine irisin increases cortical bone mass [PDF]

, 2015
It is unclear how physical activity stimulates new bone synthesis. We explored whether irisin, a newly discovered myokine released upon physical activity, displays anabolic actions on the skeleton.
Reseland, Janne E, DI COMITE, Mariasevera, Mongelli, T, Liu, P, COLAIANNI, GRAZIANA, Cinti, Saverio, Brunetti, G, Sartini, Loris, Grano, M., New, Mi, GRANO, Maria, CUSCITO, CONCETTA, Sun, Li, Zaidi, Mone, Pignataro, P, Liu, Peng, MORI, GIORGIO, Di Comite, M, Buccoliero, C, Mori, G, COLUCCI, Silvia Concetta, Pignataro, Paolo, Yuen, T, Sun, L, Yuen, Tony, New, Maria I, Colucci, Silvia, Zaidi, M, Lu, P, MONGELLI, TERESA, BUCCOLIERO, CINZIA, DI BENEDETTO, ADRIANA, Reseland, Je, Colucci, S, BRUNETTI, GIACOMINA, Di Benedetto, A, Lu, Ping, Colaianni, G, Cuscito, C   +38 more
core   +2 more sources

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Irisin levels are not affected by physical activity in patients with anorexia nervosa

Frontiers in Endocrinology, 2014
Irisin was recently identified as muscle-derived hormone that increases energy expenditure. Studies in normal weight and obese subjects reported an increased irisin expression following physical activity, although inconsistent results were observed ...
Tobias eHofmann, Ulf eElbelt, Ulf eElbelt, Anne eAhnis, Peter eKobelt, Matthias eRose, Andreas eStengel   +6 more
doaj   +1 more source

Myokines in obese adolescents with aerobic exercise

Problems of Endocrinology, 2022
BACKGROUND: Myokines are synthesized by myocytes and released into the bloodstream in response to muscle fiber contraction. They have a positive effect on carbohydrate and lipid metabolism, muscle mass growth, osteogenesis, increase tissue sensitivity to insulin, counteract inflammation of adipose tissue.
Yu. V. Kasyanova, O. V. Vasyukova, P. L. Okorokov, Z. T. Zuraeva, O. B. Bezlepkina   +4 more
openaire   +2 more sources

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism [PDF]

, 2023
No longer viewed as a metabolic waste product and cause of muscle fatigue, a contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in normal as well as pathophysiological conditions.
Brooks, George A, Moreno-Santillan, Diana D, Osmond, Adam D, Duong, Justin J, Leija, Robert G, Arevalo, Jose A, Curl, Casey C   +6 more
core   +1 more source

Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology

Frontiers in Physiology, 2021
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes.
Hyun-Kyung So, Hyun-Kyung So, Sunghee Kim, Jong-Sun Kang, Sang-Jin Lee   +4 more
doaj   +1 more source