FNDC5/irisin, a molecular target for boosting reward-related learning and motivation [PDF]
, 2018 K
Gesztelyi, Rudolf +4 more
core +1 more source
Irisin levels are not affected by physical activity in patients with anorexia nervosa
Frontiers in Endocrinology, 2014 Irisin was recently identified as muscle-derived hormone that increases energy expenditure. Studies in normal weight and obese subjects reported an increased irisin expression following physical activity, although inconsistent results were observed ...
Tobias eHofmann +6 more
doaj +1 more source
RNA-seq and metabolomic analyses of Akt1-mediated muscle growth reveals regulation of regenerative pathways and changes in the muscle secretome [PDF]
, 2017 A schematic representation of gene expression changes in the oxidative phosphorylation pathway.
Chia-Ling Wu +2 more
core +4 more sources
Aberrant Myokine Signaling in Congenital Myotonic Dystrophy [PDF]
Cell Reports, 2017 Myotonic dystrophy types 1 (DM1) and 2 (DM2) are dominantly inherited neuromuscular disorders caused by a toxic gain of function of expanded CUG and CCUG repeats, respectively. Although both disorders are clinically similar, congenital myotonic dystrophy (CDM), a severe DM form, is found only in DM1. CDM is also characterized by muscle fiber immaturity
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan ( host institution ) +9 more
openaire +4 more sources
Myokines: Novel therapeutic targets for diabetic nephropathy
Frontiers in Endocrinology, 2022 With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported.
Ming Yang +9 more
openaire +3 more sources
Advanced Science, EarlyView.A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao +22 more
wiley +1 more source
The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]
, 2019 Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio +8 more
core +1 more source
The myokine irisin increases cortical bone mass [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Although exercise is a well known and potent stimulus for new bone formation, and weightlessness or muscle loss characteristically cause bone loss, it has remained unclear how muscle talks to bone, despite their close proximity.
COLAIANNI, GRAZIANA +19 more
openaire +3 more sources
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Physical Exercise Inhibits Inflammation and Microglial Activation
Cells, 2019 Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems
Onanong Mee-inta +2 more
doaj +1 more source