Results 51 to 60 of about 8,845 (203)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation

, 2016
© 2015 by the American College of Sports Medicine. Purpose Myokines have been shown to affect muscle physiology and exert systemic effects. We endeavored to investigate a panel of myokine mRNA expression after a single exercise bout (studies 1 and 2) to ...
Galgani, Jose E., Redman, Leanne M., Tam, Charmaine S, Galgani Fuentes, José, Ravussin, E., Smith, Steven R, Noland, Robert C., Galgani, Jose E, Covington, J., Redman, Leanne M, Smith, Steven R., Smith, S., Covington, Jeffrey D., Noland, R., Bajpeyi, S., Noland, Robert C, Redman, L., Bajpeyi, Sudip, Tam, C., Covington, Jeffrey D, Ravussin, Eric, Tam, Charmaine S.   +21 more
core   +1 more source

Role of Myokines on the Bone Metabolism of Craniofacial Region: A Scoping Review

Dentistry Journal
Background: The craniofacial region is functionally unique, with close interaction between muscles and bones during mastication, speech, and facial expression.
Ahana S. Rajan, Eiji Tanaka
doaj   +1 more source

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

Metabolites, 2023
Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia.
Hajnalka Lőrincz, Sándor Somodi, Balázs Ratku, Mariann Harangi, György Paragh   +4 more
doaj   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy

Frontiers in Endocrinology, 2017
Diabetic peripheral neuropathy (DPN) remains one of the most common and serious complications of diabetes. Currently, pharmacological agents are limited to treating the pain associated with DPN, and do not address the underlying pathological mechanisms ...
Gautam Ghatnekar, April Ann Cox, Yves Sagot, Gael Hedou, Christina Grek, Travis Wilkes, Aaron I. Vinik   +6 more
doaj   +1 more source

Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

Frontiers in Physiology, 2023
The detrimental impact of obesity on human health is increasingly evident with the rise in obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance metabolism, plays a significant role as a secretory organ by releasing ...
Weimin Lin, Hongbin Song, Jieqiong Shen, Jing Wang, Yue Yang, Yinhua Yang, Jiacheng Cao, Li’e Xue, Fanglu Zhao, Tianfang Xiao, Ruiyi Lin   +10 more
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

LIF is a contraction-induced myokine stimulating human myocyte proliferation

, 2011
Background: The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of
Claus Brandt, Henriette Pilegaard, Christa Broholm, Bente Klarlund Pedersen, Vadalasetty, Radhika, Pilegaard, Henriette, Matthew J. Laye, Radhika Vadalasetty, Pedersen, Bente Klarlund, Laye, Matthew J, Brandt, Claus, Camilla Scheele, Broholm, Christa, Schéele, Camilla Charlotte   +13 more
core   +1 more source

The role of exercise-induced myokines in promoting angiogenesis

Frontiers in Physiology, 2022
Ischemic diseases are a major cause of mortality or disability in the clinic. Surgical or medical treatment often has poor effect on patients with tissue and organ ischemia caused by diffuse stenoses.
Chao Qi, Xianjing Song, He Wang, Youyou Yan, Bin Liu   +4 more
doaj   +1 more source