Results 31 to 40 of about 11,761 (240)
Frontiers in Cardiovascular Medicine, 2020 Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life.
Shingo Takada +3 more
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The Controversial Role of Irisin in Clinical Management of Coronary Heart Disease
Frontiers in Endocrinology, 2021 Irisin, a PGC1α-dependent myokine, was once believed to have beneficial effects induced by exercise. Since its first discovery of adipose browning in 2012, multiple studies have been trying to explore the metabolic functions of irisin, such as glucose ...
Wen-Lu Ou-Yang +10 more
doaj +1 more source
Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle [PDF]
, 2017 The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major
Chiesa, Claudio +4 more
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Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]
, 2014 Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph +1 more
core +1 more source
Myokines and Resistance Training: A Narrative Review
International Journal of Molecular Sciences, 2022 In the last few years, the muscular system has gained attention due to the discovery of the muscle-secretome and its high potency for retaining or regaining health. These cytokines, described as myokines, released by the working muscle, are involved in anti-inflammatory, metabolic and immunological processes. These are able to influence human health in
Beate E. M. Zunner +8 more
openaire +2 more sources
Voluntary exercise and cardiac remodeling in a myocardial infarction model
Open Medicine, 2020 We investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI ...
Shahi Hamad Al +13 more
doaj +1 more source
The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis
Endocrines, 2021 Irisin is a myokine that primarily targets adipose tissue, where it increases energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissue. As our knowledge has deepened in recent years, muscle has
Naohiro Yano, Yu Tina Zhao, Ting C. Zhao
doaj +1 more source
Irisin: A myokine with locomotor activity [PDF]
Neuroscience Letters, 2015 The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats.
Weizhen Zhang +8 more
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Dynamic and Static Exercises Differentially Affect Plasma Cytokine Content in Elite Endurance- and Strength-Trained Athletes and Untrained Volunteers [PDF]
, 2017 Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training
Anastasia V. Kabachkova +4 more
core +2 more sources
Effects of myokines on bone [PDF]
BoneKEy Reports, 2016 The links between muscle and bone have been recently examined because of the increasing number of patients with osteoporosis and sarcopenia. Myokines are skeletal muscle-derived humoral cytokines and growth factors, which exert physiological and pathological functions in various distant organs, including the regulation of glucose, energy and bone ...
openaire +2 more sources