Results 31 to 40 of about 8,085 (246)

Irisin – a myth rather than an exercise-inducible myokine [PDF]

, 2015
The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5), and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely
Thiede, Bernd, Schering, Lisa, Thomas, Selina, Holen, T, Lee, Sindre, Ohashi, T, Maak, Steffen, Erickson, HP, Norheim, F, Drevon, CA, Maak, S, Brenmoehl, Julia, Norheim, Frode, Albrecht, E, Thomas, S, Brenmoehl, J, Schering, L, Ohashi, Tomoo, Thiede, B, Albrecht, Elke, Holen, Torgeir, Drevon, Christian A., Erickson, Harold P., Lee, S   +23 more
core   +1 more source

Impact of fibronectin type III domain-containing family in the changes in metabolic and hormonal profiles during peripartum period in dairy cows

Frontiers in Veterinary Science, 2022
The peripartum period in dairy cows is frequently associated with excessive lipolysis due to Negative Energy Balance (NEB). These metabolic disorders are the cause of various pathologies.
Mathilde Daudon, Mathilde Daudon, Christelle Ramé, Anthony Estienne, Christopher Price, Joëlle Dupont   +5 more
doaj   +1 more source

48 h stimulated myokine treatment downregulated ACE2 protein levels in 16HBE14o.

, 2022
Anti-ACE2 ELISA revealed a ~53.0% downregulation of ACE2 protein with stimulated myokine treatment.
Beth Parker (1792180), Deepika Subramanyam (13124113), Hemant K. Roy (13124119), Vaishali Bhardwaj (8658189), Mart Dela Cruz (416088), Sandeep Markan (13124116), Rohit Kumar (2177842)   +6 more
core   +1 more source

Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets

Frontiers in Cardiovascular Medicine, 2020
Chronic diseases, including heart failure (HF), are often accompanied with skeletal muscle abnormalities in both quality and quantity, which are the major cause of impairment of the activities of daily living and quality of life.
Shingo Takada, Shingo Takada, Hisataka Sabe, Shintaro Kinugawa   +3 more
doaj   +1 more source

The Controversial Role of Irisin in Clinical Management of Coronary Heart Disease

Frontiers in Endocrinology, 2021
Irisin, a PGC1α-dependent myokine, was once believed to have beneficial effects induced by exercise. Since its first discovery of adipose browning in 2012, multiple studies have been trying to explore the metabolic functions of irisin, such as glucose ...
Wen-Lu Ou-Yang, Bei Guo, Feng Xu, Xiao Lin, Fu-Xing-Zi Li, Su-Kang Shan, Feng Wu, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Ling-Qing Yuan   +10 more
doaj   +1 more source

Voluntary exercise and cardiac remodeling in a myocardial infarction model

Open Medicine, 2020
We investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI ...
Shahi Hamad Al, Kadoguchi Tomoyasu, Shimada Kazunori, Fukao Kosuke, Matsushita Satoshi, Aikawa Tatsuro, Ouchi Shohei, Shiozawa Tomoyuki, Takahashi Shuhei, Sato-Okabayashi Yayoi, Akita Koji, Isoda Kikuo, Miyazaki Tetsuro, Daida Hiroyuki   +13 more
doaj   +1 more source

The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis

Endocrines, 2021
Irisin is a myokine that primarily targets adipose tissue, where it increases energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissue. As our knowledge has deepened in recent years, muscle has
Naohiro Yano, Yu Tina Zhao, Ting C. Zhao
doaj   +1 more source

Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity [PDF]

, 2019
This article belongs to the Special Issue Ketogenic Dietary Therapies: Recent Findings and Future PerspectivesThe preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity.
Baltar, Javier, Sajoux, I. (Ignacio), Lorenzo, Paula M., Casanueva, Felipe F., Javier Baltar, Portillo, M.P. (María P.), Sajoux, Ignacio, Casanueva, F.F. (Felipe F.), Castro, Ana I, Zulet, M Angeles, Tinahones, F.J. (Francisco J.), Casanueva Freijo, Felipe, Sajoux, I., Tinahones, F. J., Martínez, J. Alfredo, Paula M. Lorenzo, Crujeiras, Ana B., Castro, A. I., J. Alfredo Martinez, Crujeiras, A.B. (Ana B.), Baltar, J. (Javier), Gómez Arbeláez, Diego Eduardo, Abete, I. (Itziar), Zulet, M. A., Gómez Arbelaez, Diego, Martínez, José Alfredo, Lorenzo, P.M (Paula M.), Ana B. Crujeiras, Lorenzo, Paula M, Itziar Abete, Abete, I., Castro, A.I. (Ana I.), Lorenzo, P. M., Tinahones Madueño, Francisco José, Felipe F. Casanueva, Francisco J. Tinahones, Gomez-Arbelaez, D., Gomez-Arbelaez, Diego, Portillo, M. P., Castro, Ana I., Crujeiras Martínez, Ana Belén, Abete, Itziar, Martinez, J. A., BALTAR BOILEVE, JAVIER, Gómez-Arbelaez, D. (Diego), Martinez, A. (Alfredo), Tinahones, Francisco J., Diego Gomez-Arbelaez, Portillo Baquedano, María Puy, M. Angeles Zulet, Martinez, J Alfredo, Zulet, M.A. (María Ángeles), Ana I. Castro, Portillo, María P., Zulet, M. Angeles, Sajoux ., Ignacio, María P. Portillo, Ignacio Sajoux   +57 more
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48 h stimulated myokine treatment downregulated TMPRSS2 protein levels in 16HBE14o.

, 2022
Anti-TMPRSS2 ELISA revealed a ~32% reduction of TMPRSS2 protein with stimulated myokine treatment.
Beth Parker (1792180), Deepika Subramanyam (13124113), Hemant K. Roy (13124119), Vaishali Bhardwaj (8658189), Mart Dela Cruz (416088), Sandeep Markan (13124116), Rohit Kumar (2177842)   +6 more
core   +1 more source

FGF21 as Modulator of Metabolism in Health and Disease

Frontiers in Physiology, 2019
Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic pathways. FGF21 is expressed in several metabolically active organs and interacts with different tissues.
Caterina Tezze, Caterina Tezze, Vanina Romanello, Vanina Romanello, Marco Sandri, Marco Sandri, Marco Sandri, Marco Sandri   +7 more
doaj   +1 more source