Myokines in Acromegaly: An Altered Irisin Profile [PDF]
Frontiers in Endocrinology, 2021 IntroductionThe muscle is an endocrine organ controlling metabolic homeostasis. Irisin and myostatin are key myokines mediating this process. Acromegaly is a chronic disease with a wide spectrum of complications, including metabolic disturbances.PurposeTo examine the influence of acromegaly on irisin and myostatin secretion and their contribution to ...
Łukasz Mizera +7 more
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Physical Exercise-Induced Myokines in Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders characterized by progressive degeneration of the nervous system. Currently, there is no disease-modifying treatments for most NDs.
Banseok Lee +4 more
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FGF21 is an Akt‐regulated myokine [PDF]
FEBS Letters, 2008 Fibroblast growth factor‐21 (FGF21) functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues. In this study, we show that levels of FGF21 protein expression were similar in skeletal muscle and liver from fasted mice.
Izumiya, Yasuhiro +5 more
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Myokine Regulation as Marker of Sarcopenia in Elderly
MCBS (Molecular and Cellular Biomedical Sciences), 2018 The elderly population will increase as well as increasing life expectancy. Health problems in elderly will be more complex and need a comprehensive management. One of the problems that arise from the aging process is sarcopenia.
I Gusti Putu Suka Aryana +2 more
doaj +1 more source
Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]
, 2019 BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling +7 more
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Extracellular Vesicles: Delivery Vehicles of Myokines [PDF]
Frontiers in Physiology, 2019 Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial ...
Eleonora Trovato +4 more
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Beneficial effect of voluntary exercise on experimental colitis in mice fed a high-fat diet : the role of irisin, adiponectin and proinflammatory biomarkers [PDF]
, 2017 Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn‘s disease and ulcerative colitis.
Bilski, Jan +10 more
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Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review [PDF]
Journal of Exercise & Organ Cross TalkSkeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations.
Hossein Shirvani +2 more
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Cardiovascular Response and Serum Interleukin-6 Level in Concentric Vs. Eccentric Exercise [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Cardiovascular Disease (CVD) is a leading cause of morbidity and mortality in India. Resistance exercise is strongly recommended for implementation in CVD prevention programs.
Mayank Agarwal +5 more
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Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones
eLife, 2022 Skeletal muscle plays an integral role in coordinating physiological homeostasis, where signaling to other tissues via myokines allows for coordination of complex processes.
Leandro M Velez +6 more
doaj +1 more source