Results 11 to 20 of about 8,085 (246)
A new member of the myokine family: Irisin
Medicine Science, 2017 Skeletal muscle is an important tissue which functions as an endocrine organ and secretes the factors called myokine. Irisin is a thermogenic peptide which has been recently defined as a new myokine.
Cigdem Tekin +2 more
doaj +2 more sources
Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones [PDF]
eLife, 2022 Skeletal muscle plays an integral role in coordinating physiological homeostasis, where signaling to other tissues via myokines allows for coordination of complex processes.
Leandro M Velez +6 more
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Myokines in Acromegaly: An Altered Irisin Profile [PDF]
Frontiers in Endocrinology, 2021 IntroductionThe muscle is an endocrine organ controlling metabolic homeostasis. Irisin and myostatin are key myokines mediating this process. Acromegaly is a chronic disease with a wide spectrum of complications, including metabolic disturbances.PurposeTo examine the influence of acromegaly on irisin and myostatin secretion and their contribution to ...
Łukasz Mizera +7 more
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FGF21 is an Akt‐regulated myokine [PDF]
FEBS Letters, 2008 Fibroblast growth factor‐21 (FGF21) functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues. In this study, we show that levels of FGF21 protein expression were similar in skeletal muscle and liver from fasted mice.
Izumiya, Yasuhiro +5 more
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Downregulation of ACE2 mRNA with 48 h stimulated myokine treatment.
, 2022 (a): ACE2 qPCR in 16HBE14o. ACE2 mRNA was also shown to be downregulated with stimulated myokine treatment by 32.5%. (b): ACE qPCR in A549. Stimulated myokine treatment resulted 63.9% downregulation of ACE2 gene expression.
Beth Parker (1792180) +6 more
core +1 more source
Heat Map of Top 20 upregulated and downregulated proteins in myokine fractions.
, 2022 Proteomic characterization through Tandem Mass Tag Label Mass Spectroscopy revealed marked changes in protein abundance between stimulated and unstimulated myokine fraction. A.
Beth Parker (1792180) +6 more
core +1 more source
Muscles and their myokines [PDF]
Journal of Experimental Biology, 2011 SummaryIn the past, the role of physical activity as a life-style modulating factor has been considered as that of a tool to balance energy intake. Although it is important to avoid obesity, physical inactivity should be discussed in a much broader context.
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Irisin: A myokine with locomotor activity [PDF]
Neuroscience Letters, 2015 The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats.
Weizhen Zhang +8 more
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Role of myokines and osteokines in cancer cachexia [PDF]
Experimental Biology and Medicine, 2021 Cancer-induced muscle wasting, i.e. cachexia, is associated with different types of cancer such as pancreatic, colorectal, lung, liver, gastric and esophageal. Cachexia affects prognosis and survival in cancer, and it is estimated that it will be the ultimate cause of death for up to 30% of cancer patients.
Fabrizio Pin +2 more
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The impact of mild hypoxia exposure on myokine secretion in human obesity
, 2023 Background/ObjectiveCompelling evidence indicates that myokines act in an autocrine, paracrine and endocrine manner to alter metabolic homeostasis. The mechanisms underlying exercise-induced changes in myokine secretion remain to be elucidated.
Blaak, E.E. +13 more
core +1 more source