Results 1 to 10 of about 161,523 (294)

Multifaceted Function of Myosin-18, an Unconventional Class of the Myosin Superfamily

open access: yesFrontiers in Cell and Developmental Biology, 2021
Myosin is a diverse superfamily of motor proteins responsible for actin-based motility and contractility in eukaryotic cells. Myosin-18 family, including myosin-18A and myosin-18B, belongs to an unconventional class of myosin, which lacks ATPase motor ...
Zhaohui Ouyang   +12 more
doaj   +1 more source

Purification of Myosin from Bovine Tracheal Smooth Muscle, Filament Formation and Endogenous Association of Its Regulatory Complex

open access: yesCells, 2023
Dynamic regulation of myosin filaments is a crucial factor in the ability of airway smooth muscle (ASM) to adapt to a wide length range. Increased stability or robustness of myosin filaments may play a role in the pathophysiology of asthmatic airways ...
Lu Wang   +3 more
doaj   +1 more source

Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading. [PDF]

open access: yesPLoS ONE, 2010
Non-muscle cells express multiple myosin-II motor proteins myosin IIA, myosin IIB and myosin IIC transcribed from different loci in the human genome. Due to a significant homology in their sequences, these ubiquitously expressed myosin II motor proteins ...
Venkaiah Betapudi
doaj   +1 more source

Dynamics of Myosin II Filaments during Wound Repair in Dividing Cells

open access: yesCells, 2021
Wound repair of cell membranes is essential for cell survival. Myosin II contributes to wound pore closure by interacting with actin filaments in larger cells; however, its role in smaller cells is unclear.
Md. Istiaq Obaidi Tanvir   +3 more
doaj   +1 more source

The ubiquitin ligase Ozz decreases the replacement rate of embryonic myosin in myofibrils

open access: yesPhysiological Reports, 2021
Myosin, the most abundant myofibrillar protein in skeletal muscle, functions as a motor protein in muscle contraction. Myosin polymerizes into the thick filaments in the sarcomere where approximately 50% of embryonic myosin (Myh3) are replaced within 3 h
Emi Ichimura   +5 more
doaj   +1 more source

Temperature-Dependent Activity of Motor Proteins: Energetics and Their Implications for Collective Behavior

open access: yesFrontiers in Cell and Developmental Biology, 2021
Molecular motor proteins are an extremely important component of the cellular transport system that harness chemical energy derived from ATP hydrolysis to carry out directed mechanical motion inside the cells. Transport properties of these motors such as
Saumya Yadav, Ambarish Kunwar
doaj   +1 more source

Generation of stress fibers through myosin-driven reorganization of the actin cortex

open access: yeseLife, 2021
Contractile actomyosin bundles, stress fibers, govern key cellular processes including migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental morphogenesis. The most prominent actomyosin bundles, ventral stress fibers,
Jaakko I Lehtimäki   +3 more
doaj   +1 more source

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

open access: yeseLife, 2022
Mutations in the lever arm of β-cardiac myosin are a frequent cause of hypertrophic cardiomyopathy, a disease characterized by hypercontractility and eventual hypertrophy of the left ventricle.
Makenna M Morck   +5 more
doaj   +1 more source

Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in mammalian cells

open access: yesEuropean Journal of Histochemistry, 2009
Myosin is a functional protein associated with cellular movement, cell division, muscle contraction and other functions. Members of the myosin super-family are distinguished from the myosin heavy chains that play crucial roles in cellular processes ...
T Takubo   +6 more
doaj   +1 more source

Targeting cytoskeletal phosphorylation in cancer

open access: yesExploration of Targeted Anti-tumor Therapy, 2021
Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to migrate and divide.
Clara Llorente-González   +2 more
doaj   +1 more source

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