Results 21 to 30 of about 182,146 (218)

Mechanisms in the pathogenesis of poststroke spasticity

open access: yesНеврология, нейропсихиатрия, психосоматика, 2011
Objective: to study the mechanisms of poststroke spasticity and the role of structural and functional impairments of skeletal muscles in its pathogenesis. Patients and methods.
E. A. Katushkina   +3 more
doaj   +1 more source

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

open access: yesBiology Open, 2021
The fundamental basis of muscle contraction ‘the sliding filament model’ (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the ‘swinging, tilting crossbridge-sliding filament mechanism’ (Huxley, 1969; Huxley and Brown, 1967) nucleated a field ...
Manuel Schmid, Christopher N. Toepfer
doaj   +1 more source

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]

open access: yes, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L.   +15 more
core   +1 more source

Isolation and identification of actin-binding proteins in Plasmodium falciparum by affinity chromatography

open access: yesMemorias do Instituto Oswaldo Cruz, 2000
The invasion of the erythrocyte by Plasmodium falciparum depends on the ability of the merozoite to move through the membrane invagination. This ability is probably mediated by actin dependent motors.
Claudia Forero, Moisés Wasserman
doaj   +1 more source

Breaking the clip for cargo unloading from motor proteins: mechanism and significance

open access: yesMicrobial Cell, 2022
The mitochondrion is an essential organelle involved in ATP generation, lipid metabolism, regulation of calci- um ions, etc. Therefore, it should be inherited properly by newly generated cells.
Keisuke Obara, Takumi Kamura
doaj   +1 more source

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle. [PDF]

open access: yes, 1996
The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was
Shrimpton, C.   +10 more
core   +1 more source

Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells [PDF]

open access: yes, 2009
© The Authors, 2009 . This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 186 (2009): 727-738, doi:10.1083/jcb ...
Vale, Ronald D.   +5 more
core   +1 more source

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

open access: yesFrontiers in Neuroscience, 2023
Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control.
Dengfeng Lu   +8 more
doaj   +1 more source

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

open access: yeseLife, 2019
Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment.
Michael S Woody   +4 more
doaj   +1 more source

Type-I myosins promote actin polymerization to drive membrane bending in endocytosis

open access: yeseLife, 2019
Clathrin-mediated endocytosis in budding yeast requires the formation of a dynamic actin network that produces the force to invaginate the plasma membrane against the intracellular turgor pressure.
Hetty E Manenschijn   +5 more
doaj   +1 more source

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