Results 111 to 120 of about 161,523 (294)
Selective purification of the thiol peptides of myosin [PDF]
, 1968 Alan G. Weeds, B S Hartley
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Advanced Science, EarlyView.The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park +9 more
wiley +1 more source
Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen +9 more
wiley +1 more source
The temperature dependence of myosin-adenosinetriphosphatase and alkaline phosphatase in lizards [PDF]
, 1964 Paul Licht
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Advanced Science, EarlyView.The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding +19 more
wiley +1 more source
From amoeboid myosin to unique targeted medicines for a genetic cardiac disease
Frontiers in PhysiologyThe importance of fundamental basic research in the quest for much needed clinical treatments is a story that constantly must be retold. Funding of basic science in the USA by the National Institutes of Health and other agencies is provided under the ...
James A. Spudich
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THE ROLE OF WATER IN ENZYMATIC HYDROLYSIS: GENERAL METHOD AND ITS APPLICATION TO MYOSIN
, 1957 Daniel E. Koshland, Earl B. Herr
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Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy
Advanced Science, EarlyView.As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang +4 more
wiley +1 more source
Advanced Science, EarlyView.This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao +8 more
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