The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]
, 2014 The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo +62 more
core +1 more source
Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
eLife, 2019 Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment.
Michael S Woody +4 more
doaj +1 more source
Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
Frontiers in Neuroscience, 2023 Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control.
Dengfeng Lu +8 more
doaj +1 more source
Type-I myosins promote actin polymerization to drive membrane bending in endocytosis
eLife, 2019 Clathrin-mediated endocytosis in budding yeast requires the formation of a dynamic actin network that produces the force to invaginate the plasma membrane against the intracellular turgor pressure.
Hetty E Manenschijn +5 more
doaj +1 more source
Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
core +1 more source
A Python based automated tracking routine for myosin II filaments [PDF]
, 2020 The study of motor protein dynamics within cytoskeletal networks is of high interest to physicists and biologists to understand how the dynamics and properties of individual motors lead to cooperative effects and control of overall network behaviour ...
Köster, Darius Vasco +2 more
core +2 more sources
Diffusion of myosin V on microtubules [PDF]
, 2011 Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma +4 more
core +1 more source
Influence of chilled and frozen storage on the stability of trout and herring fillet [PDF]
, 2006 Effects of chilled and frozen storage on specific enthalpy (ΔH) and transition temperature (Td) of protein denaturation as well as on selected functional properties of muscle tissue of rainbow trout and herring were investigated. The Td of myosin shifted
Beyrer, Michael, Rüsch, Mark
core +2 more sources
eLife, 2021 Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. The cytoneme morphogen transport model posits that specialized filopodia extend between morphogen-sending and responding cells to ensure that ...
Eric T Hall +12 more
doaj +1 more source
Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Amira, M +3 more
core +2 more sources