Results 51 to 60 of about 380,707 (403)

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Small-molecule allosteric effectors designed to target and modulate striated and smooth myosin isoforms for the treatment of disease show promise in preclinical and clinical trials.
John A. Rohde, O. Roopnarine, David D. Thomas, Joseph M. Muretta   +3 more
semanticscholar   +1 more source

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

Nature Communications, 2018
Omecamtiv mecarbil (OM) is a positive cardiac inotrope in phase-3 clinical trials for treatment of heart failure. Although initially described as a direct myosin activator, subsequent studies are at odds with this description and do not explain OM ...
Michael S. Woody, M. Greenberg, M. Greenberg, Bipasha Barua, D. Winkelmann, Y. Goldman, E. Ostap   +6 more
semanticscholar   +1 more source

Quantum dot-based thermometry uncovers decreased myosin efficiency in an experimental intensive care unit model

Frontiers in Physiology
Critical illness myopathy (CIM) detrimentally affects muscle function in ICU patients, with a dramatic loss of muscle mass and function where the loss in specific force exceeds the loss in muscle mass (maximum force normalized to muscle cross-sectional ...
Meishan Li, Meishan Li, Nicola Cacciani, Nicola Cacciani, Fernando Ribeiro, Fernando Ribeiro, Fernando Ribeiro, Yvette Hedström, Yvette Hedström, Bhanu P. Jena, Bhanu P. Jena, Lars Larsson, Lars Larsson, Lars Larsson   +13 more
doaj   +1 more source

Estudo de mutações causadoras de cardiomiopatia hipertrófica em um grupo de pacientes no Espírito Santo, Brasil Estudio de mutaciones causadoras de cardiomiopatía hipertrófica en un grupo de pacientes en Espírito Santo, Brasil Study of mutations causing hypertrophic cardiomyopathy in a group of patients from Espirito Santo, Brazil

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: A cardiomiopatia hipertrófica (CH) é a doença cardíaca hereditária mais frequente, causada por mutações nos genes codificadores para proteínas do sarcômero. Embora mais de 430 mutações tenham sido identificadas em vários continentes e países,
Júlia Daher Carneiro Marsiglia, Maria do Carmo Pimentel Batitucci, Flávia de Paula, Clara Barbirato, Edmundo Arteaga, Aloir Queiroz de Araújo   +5 more
doaj   +1 more source

F-actin and myosin F control apicoplast elongation dynamics which drive apicoplast-centrosome association in Toxoplasma gondii

mBio, 2023
Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death.
Parvathi Madhavi Devarakonda, Valeria Sarmiento, Aoife T. Heaslip   +2 more
doaj   +1 more source

HLH-1 Modulates Muscle Proteostasis During Caenorhabditis elegans Larval Development

Frontiers in Cell and Developmental Biology, 2022
Muscle proteostasis is shaped by the myogenic transcription factor MyoD which regulates the expression of chaperones during muscle differentiation. Whether MyoD can also modulate chaperone expression in terminally differentiated muscle cells remains open.
Khairun Nisaa, Anat Ben-Zvi
doaj   +1 more source

Zebrafish as a Model for the Study of Live in vivo Processive Transport in Neurons

Frontiers in Cell and Developmental Biology, 2019
Motor proteins are responsible for transport of vesicles and organelles within the cell cytoplasm. They interact with the actin cytoskeleton and with microtubules to ensure communication and supply throughout the cell.
Valérie Bercier, Valérie Bercier, Marion Rosello, Filippo Del Bene, Céline Revenu   +4 more
doaj   +1 more source

Molecular to organismal chirality is induced by the conserved myosin 1D

Science, 2018
A single myosin sets chirality at all scales When viewed externally, most organisms appear symmetric between the left and right sides. However, many organs are left-right asymmetric. Whether macroscopic asymmetries are directly related to molecular-level
G. Lebreton, C. Géminard, F. Lapraz, S. Pyrpassopoulos, D. Cerezo, P. Spéder, E. Ostap, S. Noselli   +7 more
semanticscholar   +1 more source

Diffusion of myosin V on microtubules [PDF]

, 2011
Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma, Schliwa, Manfred, Voith von Voithenberg, Lena, Zimmermann, Dennis, Ökten, Zeynep   +4 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source