Results 61 to 70 of about 380,707 (403)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton

Cells, 2020
MicroRNAs (miRNAs) are key modulators of post-transcriptional gene regulation in a plethora of processes, including actin–myosin cytoskeleton dynamics.
Karen Uray, Evelin Major, Beata Lontay
doaj   +1 more source

Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]

, 2016
BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira, Harrison, Linda M, Kass, Phil H, Knych, Heather K, Steinmetz, Stacy J   +4 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

MYO, a Candidate Gene for Haploid Induction in Maize Causes Male Sterility

Plants, 2020
Doubled haploid technology is highly successful in maize breeding programs and is contingent on the ability of maize inducers to efficiently produce haploids.
Kimberly Vanous, Thomas Lübberstedt, Rania Ibrahim, Ursula K. Frei   +3 more
doaj   +1 more source

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

Journal of Biological Chemistry, 2017
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy, one of the most prevalent heritable cardiovascular ...
Raja Kawas, R. Anderson, Sadie R. Bartholomew Ingle, Yonghong Song, A. Sran, Hector M. Rodriguez   +5 more
semanticscholar   +1 more source

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]

, 2013
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Doller, Anke, Eberhardt, Wolfgang, Pfeilschifter, Josef Martin, Schulz, Sebastian   +3 more
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

An expanded role of the SNARE-containing regulon as it relates to the defense process that Glycine max has to Heterodera glycines

Journal of Plant Interactions, 2019
The defense regulon has been defined genetically in Arabidopsis thaliana to involve the syntaxin PENETRATION1 (PEN1), the secreted glucosidase (PEN2) and an ATP-binding cassette (ABC) transporter (PEN3).
Hannah W. Austin, Brant T. McNeece, Keshav Sharma, Prakash M. Niraula, Katherine S. Lawrence, Vincent P. Klink   +5 more
doaj   +1 more source

Uncoupling apical constriction from tissue invagination

eLife, 2017
Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular ...
SeYeon Chung, Sangjoon Kim, Deborah J Andrew   +2 more
doaj   +1 more source