Results 101 to 110 of about 20,573 (287)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

Advanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue, Kaiwen Wu, Bing Wei, Guiling Song, Congyu Sun, Xing Li, Xiangyu Liu, Zhaoxiang Ma, Mingchun Lv, Jasper Landman, Yuan Li   +10 more
wiley   +1 more source

Fluctuation relations for molecular motors

, 2010
This review is focused on the application of specific fluctuation relations, such as the Gallavotti-Cohen relation, to ratchet models of a molecular motor. A special emphasis is placed on two-states models such as the flashing ratchet model.
Lacoste, D., Mallick, K.
core   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries [PDF]

, 2007
Smooth muscle myosin heavy chains occur in 2 isoforms, SMA (slow) and SMB (fast). We hypothesized that the SMB isoform is predominant in the faster-contracting rat vena cava compared to thoracic aorta.
Eddinger, Thomas, Fink, Gregory D, Kayal, Anas, Rondelli, Catherine M, Rovner, Arthur S, Szasz, Irina T, Thakali, Keshari, Watson, Ralph E, Watts, Stephanie W   +8 more
core   +1 more source

Possible origins of macroscopic left-right asymmetry in organisms

, 2012
I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules.
A. Tamada, A. Varma, A. Vilfan, A.M. Heacock, A.R. Palmer, C. Ambrose, C. Arrieumerlou, C. McManus, C. Pohl, C.H. Wiggins, C.L. Henley, C.R. Cowan, C.S. Peskin, C.W. Wolgemuth, Christopher L. Henley, D. Vavylonis, D.S. Adams, D.W. Ehrhardt, E. Ben-Jacob, E. Ben-Jacob, E. Kawamura, E.C. Eren, E.C. Eren, E.E. Deinum, F. Ziebert, F.C. Frank, G. Salbreux, G.M. Grason, G.O. Wasteneys, H. Hamada, H.F. Romijn, I. Mabuchi, J. Chan, J. Chan, J. Cooke, J. Gore, J. Hagmann, J. Salje, J. Xu, J.A. Åström, J.F. Allard, J.F. Allard, J.F. Beausang, J.H.E. Cartwright, K. Taniguchi, L.F. Jones, L.Q. Wan, M. Levin, M. Levin, M. Levin, M. Mayer, M.E. Halpern, M.L. Manning, M.P. Wold, M.V. Danilchik, M.V. Thompson, M.Y. Ali, N. Hirokawa, N. Morone, N.A. Brown, N.H. Mendelson, N.H. Mendelson, P. Spéder, P. Spéder, R. Dixit, R. Kawamura, R. Kuroda, R.D. Kamien, R.D. Preston, R.J. Hawkins, R.J. Poole, R.M. Figge, S. Aw, S. Hozumi, S. Nonaka, S. Nonaka, S. Thitamadee, S. Wang, S.H. Tindemans, S.L. Shaw, S.S. Andrews, T. Hashimoto, T. Ishida, T. Kamasaki, T. Lionnet, T. Nishizaka, T. Okumura, T. Sun, T.-H. Chuan, V.A. Avertisov, V.A. Baulin, W. Lauga, W.B. Wood, W.B. Wood, W.B. Wood, W.R. DiLuzio, X.-Q. Shi, Y. Nakadera, Y. Shibazaki, Y. Wu, Y.B. Malashichev   +100 more
core   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Plant-specific myosin XI, a molecular perspective

Frontiers in Plant Science, 2012
In eukaryotic cells, organelle movement, positioning, and communications are critical for maintaining cellular functions and are highly regulated by intracellular trafficking.
Motoki eTominaga, Motoki eTominaga, Akihiko eNakano, Akihiko eNakano   +3 more
doaj   +1 more source