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Single-molecule experiments in biological physics: methods and applications

, 2006
I review single-molecule experiments (SME) in biological physics. Recent technological developments have provided the tools to design and build scientific instruments of high enough sensitivity and precision to manipulate and visualize individual ...
, , , , , Adachi K, Adelman K, Ahsan A, Alberts B, Allahverdyan A, Allemand J F, Altan-Bonnet G, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Astumian R D, Astumian R D, Baumann C G, Baumann C G, Bell G I, Bennett C H, Bennink M L, Bennink M L, Bensimon D, Best R B, Bhasin N, Bhattacharjee S M, Bhattacharjee S M, Binnig G, Binnig G, Blanchard S C, Blickle V, Block S M, Block S M, Bloomfield V A, Bochkov G N, Bockelmann U, Boroudjerdi H, Bouchiat C, Braslavsky I, Brower-Toland B D, Brujic J, Bryant Z, Bundschuh R, Burgess S A, Bustamante C, Bustamante C, Bustamante C, Bustamante C, Calladine C R, Carl P, Carrion-Vazquez M, Carrion-Vazquez M, Carrion-Vazquez M, Carter N J, Carter N J, Causo M S, Charvin G, Chatenay D, Chen S-J, Ciliberto S, Clausen-Schaumann H, Cluzel P, Cocco S, Cocco S, Cocco S, Cocco S, Cocco S, Cohen E G D, Cohen E G D, Cohen E G D, Crooks G E, Crooks G E, Cross R A, Cuesta-Lopez S, Cui Y, Cui Y, Cule D, Czajkowsky D M, Córdova N J, Daban J R, Dammer U, Dammer U, Danilowicz C, Davenport R J, De Duve C, Dekker N H, Deng H, Discher D E, Dohoney K M, Douarche F, Eisenberg E, Engel A, Essevaz-Roulet B, Evans D J, Evans E, Evans E, Evans E, Evans E, Evans E, F Ritort, Fain B, Fernandez J M, Fernandez J M, Fernandez J M, Finer J T, Finkelstein A V, Finzi L, Fisher M E, Florin E L, Flyvbjerg H, Forde N R, Forkey J N, Frank-Kamentskii M D, Frechet J M, Fritz J, Fréchet J M J, Gallavotti G, Garces-Chavez V, Garcia-Manyes S, Gelles J, Gelles J, Gelles J, Gergely C, Gerland U, Gerland U, Gerland U, Gestland R F, Goel A, Goel A, Gordon M P, Gore J, Gore J, Gosse C, Grange W, Green N H, Grier D G, Gross D H E, Ha T, Ha T, Hafner J H, Hanggi P, Hanke A, Hanley W, Hansen J C, Haran G, Harlepp S, Herschlag D, Higgs P G, Hill T L, Hill T L, Hinterdorfer P, Howard J, Hummer G, Hummer G, Hwa T, Hyeon C, Inoue A, Isralewitz B, Jarzynski C, Jarzynski C, Jarzynski C, Jarzynski C, Jensen M O, Jeruzalmi D, Junier I Ritort F, Jülicher F, Kafri Y, Katritch V, Kawakami M, Keller D, Keller D, Kellermayer M S K, Kellermayer M S, Kim H D, Kindt J, Kitamura K, Klimov D K, Klug A, Konrad M W, Kosikov K M, Kosztin I, Kramers H A, Kukowska-Latallo J F, Kunze K-K, Kurchan J, Kühner F, Ladoux B, Lang M J, Lang M J, Law R, Lebowitz J L, Lebrun A, Lee G U, Lee G U, Leger J F, Leuba S H, Leuva S H, Lhua R C, Li P T X Bustamante C Tinoco I, Liphardt J, Liu F, Lu H, Léger J F, Maes C, Maes C, Maier B, Manosas M, Manosas M Wen J D Li P T X Smith S B Bustamante C Tinoco I Ritort F, Marko J, Marko J, Marko J F, Marszalek P E, Marszalek P E, Marszalek P E, Masaike T, Mathews D H, Mazonka O Jarzynski C, McGurn A R, Merkel R, Min W, Moffitt J R, Molloy J E, Moy V T, Muller D J, Munoz V, Müller D J, Müller M, Müller M, Nayashima M, Nelson D R, Nguyen T T Grossberg A Y Shklovskii B I Holm C Kekicheff P Podgornik R, Noji H, Noy A, Oberhauser A F, Onoa B, Onoa B, Onuchic J N, Oono Y, Orland H, Orlandini E, Orphanides G, Paci E, Pagnani A, Pan J, Pant K, Park S, Pauling L, Perret E, Peyrard M, Phillips W D, Poirier M G, Poland D, Poland D, Purohit P K, Qian H, Qu X, Rief M, Rief M, Rief M, Rief M, Rief M, Rief M, Ritort F, Ritort F, Ritort F, Ritort F, Ros R, Rouzina I, Rouzina I, Rubinstein M, Saleh O A, Sarkar A, Schiessel H, Schiessel H, Schlierf M, Schroeder R, Schumakovitch I, Schurr J M, Schwesinger F, Seifert U, Sellers J R, Shaevitz J W, Smith B L, Smith D E, Smith S B, Soong R K, Sosnick T R, Speck T, Spudich A, Strick T, Strick T R, Strick T R, Strick T R, Strunz T, Svoboda K, Tanaka H, Thirumalai D, Thurmond K B, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Treiber D K, Treiber D K, Trepagnier E H, Tsallis C, Uemura S, Uptain S M, Valpuesta J M, Vanzi F, Veigel C, Veigel C, Visscher K, Vologodskii A, Wang M D, Wang M D, Wartell R M, Watson J D, Watson J D, Wen J D Manosas M Li P T X Smith S B Bustamante C Ritort F Tinoco I, Wenner J R, Widom J, Wiita A P, Wilkins M H F, Williams M C, Williams M C, Williams M C, Williams P M, Williams P M, Wood R H, Woodcock C L, Wuite G J L, Xie Z, Yager T D, Yang G, Yasuda R, Yasuda R, Yildiz A, Yildiz A, Yin H, Zandi R, Zarrinkar P, Zhou H, Zhuang X, Zuckermann D M, Zuker M, Zwanzig R W   +351 more
core   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols.

PLoS ONE, 2010
BackgroundNitric oxide (NO) has long been recognized to affect muscle contraction, both through activation of guanylyl cyclase and through modification of cysteines in proteins to yield S-nitrosothiols. While NO affects the contractile apparatus directly,
Alicia M Evangelista, Vijay S Rao, Ashley R Filo, Nadzeya V Marozkina, Allan Doctor, David R Jones, Benjamin Gaston, William H Guilford   +7 more
doaj   +1 more source

Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death in Arabidopsis

Frontiers in Plant Science, 2018
The integrity and dynamics of actin cytoskeleton is necessary not only for plant cell architecture but also for membrane trafficking-mediated processes such as polar auxin transport, senescence, and cell death.
Eve-Ly Ojangu, Birger Ilau, Krista Tanner, Kristiina Talts, Eliis Ihoma, Valerian V. Dolja, Heiti Paves, Erkki Truve   +7 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Experiment K-6-10. Effects of zero gravity on myofibril protein content and isomyosin distribution in rodent skeletal muscle [PDF]

The purpose of this experiment was to investigate the effects of 12 days of zero gravity (0G) exposure (Cosmos 1887 Biosputnik) on the enzymatic properties, protein content, and isomyosin distribution of the myofibril fraction of the slow-twitch vastus ...
Baldwin, K., Herrick, R., Oganov, V.
core   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source