Results 111 to 120 of about 20,285 (238)
3D-environment and muscle contraction regulate the heterogeneity of myonuclei. [PDF]
Nicolas R+5 more
europepmc +1 more source
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak+4 more
wiley +1 more source
Pre‐oviposition development of the brown anole (Anolis sagrei)
Abstract Background The brown anole, Anolis sagrei, has emerged as a representative squamate species for developmental studies during the past decades. Novel functional tools have been established to manipulate embryogenesis through genome editing or the introduction of small molecule inhibitors, and their effective use requires a thorough ...
Antonia Weberling+9 more
wiley +1 more source
High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory. [PDF]
Chavali SS+4 more
europepmc +1 more source
Myomaker and Myomixer are required for craniofacial myoblast fusion in zebrafish
Abstract Background Craniofacial and trunk skeletal muscles are derived from different progenitor populations during development. Trunk skeletal muscles contain mostly multinucleated myofibers that are formed through myoblast fusion. However, myoblast fusion in craniofacial muscles and its molecular regulation are not well understood.
Zhanxiong Zhang+3 more
wiley +1 more source
Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states. [PDF]
Cail RC+4 more
europepmc +1 more source
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel+5 more
wiley +1 more source
Myosin IXB protects immune cells from virus infection. [PDF]
Kogachi L+8 more
europepmc +1 more source
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler+4 more
wiley +1 more source