Results 51 to 60 of about 50,269 (229)
, 2007 Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton.
Achim Besser +14 more
core +1 more source
Myosin VI regulates the spatial organisation of mammalian transcription initiation
Nature Communications, 2022 The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a ...
Yukti Hari-Gupta +15 more
doaj +1 more source
Evolution and Classification of Myosins, a Paneukaryotic Whole-Genome Approach [PDF]
, 2014 notes: PubMed ID: 24443438© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.Myosins are key components of the eukaryotic cytoskeleton, providing motility for a broad diversity of ...
Grau-Bove, X +3 more
core +2 more sources
BMC Genomics, 2009 Background Motor proteins have extensively been studied in the past and consist of large superfamilies. They are involved in diverse processes like cell division, cellular transport, neuronal transport processes, or muscle contraction, to name a few ...
Kollmar Martin +2 more
doaj +1 more source
Myosin XVA: dancing at the tips of the stereocilia
Journal of Bio-X Research, 2020 . Myosins comprise a large superfamily of adenosine triphosphatases (ATPases) that interact with actin filaments to generate motility or force. Unconventional myosins are implicated in diverse cellular processes including organelle trafficking, F-actin ...
Haibo Du, Nana Li, Zhigang Xu
doaj +1 more source
Extent of myosin penetration within the actin cortex regulates cell surface mechanics
Nature Communications, 2021 Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement ...
Binh An Truong Quang +7 more
doaj +1 more source
Cooperative transport by small teams of molecular motors [PDF]
, 2006 Molecular motors power directed transport of cargoes within cells. Even if a single motor is sufficient to transport a cargo, motors often cooperate in small teams.
Klumpp, Stefan +2 more
core +2 more sources
Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
Molecular Brain, 2018 The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na+/K+-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to establish a cellular ...
Bhagirathi Dash +2 more
doaj +1 more source
Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
core +1 more source
Myosins in Osteoclast Formation and Function
Biomolecules, 2018 Skeletal quantity and quality are determined by processes of bone modeling and remodeling, which are undertaken by cells that build and resorb bone as they respond to mechanical, hormonal, and other external and internal signals.
Beth S. Lee
doaj +1 more source