Biomolecules, 2023 Myostatin (growth differentiation factor 8) is a member of the transforming growth factor-β superfamily. It is secreted mostly by skeletal muscles, although small amounts of myostatin are produced by the myocardium and the adipose tissue as well ...
Małgorzata Knapp +2 more
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Temporal and intra-horse consistency of circulating myostatin concentrations in Thoroughbred racehorses [PDF]
Scientific ReportsIn Thoroughbred horses, a highly prevalent short interspersed nuclear element (SINE) mutation in the myostatin gene (MSTN) promoter influences circulating myostatin concentration and is associated with muscle morphology, fracture risk and optimal race ...
Katherine Hanousek +3 more
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Discovery of a mammalian splice variant of myostatin that stimulates myogenesis. [PDF]
PLoS ONE, 2013 Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals.
Ferenc Jeanplong +11 more
doaj +5 more sources
Myostatin antisense administration prevents sepsis‐induced muscle atrophy and weakness in male mice [PDF]
Physiological ReportsMuscle atrophy and weakness are serious problems associated with sepsis. However, only a few pharmacological interventions are available to date. In this study, myostatin antisense was used to prevent sepsis‐induced muscle atrophy and weakness.
Nobuto Nakanishi +8 more
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Correlations of serum myostatin and irisin with sarcopenia and osteoporosis in rheumatoid arthritis patients: a cross-sectional study [PDF]
Scientific ReportsMyostatin and irisin, the key regulators of muscle metabolism, are myokines secreted by skeletal muscles that significantly influence osteoporosis (OP) and sarcopenia.
Wan-jun Li +4 more
doaj +2 more sources
A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta +3 more
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Myostatin is upregulated following stress in an Erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model. [PDF]
PLoS ONE, 2010 Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to characterize myostatin regulation following cardiomyocyte stress and to examine the role of ...
Lawrence T Bish +3 more
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Signals of Ezh2, Src, and Akt Involve in myostatin-Pax7 pathways regulating the myogenic fate determination during the sheep myoblast proliferation and differentiation. [PDF]
PLoS ONE, 2015 Myostatin and Pax7 have been well documented individually, however, the mechanism by which Myostatin regulates Pax7 is seldom reported. Here, based on muscle transcriptome analysis in Texel (Myostatin mutant) and Ujumqin (wild type) sheep across the five
Caihong Wei +9 more
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Regulation of Myostatin on the Growth and Development of Skeletal Muscle
Frontiers in Cell and Developmental Biology, 2021 Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively regulate the growth and development of skeletal muscle by autocrine or paracrine signaling.
Ming-Ming Chen +4 more
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Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. [PDF]
PLoS ONE, 2010 Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia.
Kevin J Morine +5 more
doaj +1 more source