Results 11 to 20 of about 26,633 (217)
Circulation, 2010 Cachexia in chronic heart failure (HF) is a major clinical problem that is still underestimated for its impact on morbidity, mortality, and healthcare expenditures. The pathophysiology of cardiac cachexia is characterized by a catabolic/anabolic imbalance.
Springer, Jochen +2 more
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Myostatin: Expanding horizons [PDF]
IUBMB Life, 2015 AbstractMyostatin is a secreted growth and differentiation factor that belongs to the TGF‐β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels ...
Sharma, Mridula +5 more
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Les Cahiers de Myologie, 2016 L’unique modele murin reproduisant la myopathie centronucleaire autosomique dominante associe a une mutation du gene dynamine -2 (KI-dnm2 R465W/+ ) reproduit la plupart des signes cliniques observes chez l’Homme, notamment une atrophie et une perte de force musculaire.
David Arnould, Anne-Cécile Durieux
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Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. [PDF]
PLoS ONE, 2011 The marked hypermuscularity in mice with constitutive myostatin deficiency reduces fat accumulation and hyperglycemia induced by high-fat feeding, but it is unclear whether the smaller increase in muscle mass caused by postdevelopmental loss of myostatin
Kerri Burgess +4 more
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BMC Nutrition, 2022 Background Elevated concentrations of myostatin inhibit muscle growth, function and strength. Myostatin is a mediator of sarcopenia and is associated with insulin resistance.
Cydne A. Perry +2 more
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Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Frontiers in Physiology, 2022 Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target.
Mohammad Hassan Baig +18 more
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Biomolecules, 2020 Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size.
Juulia H. Lautaoja +5 more
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Serum myostatin is reduced in individuals with metabolic syndrome. [PDF]
PLoS ONE, 2014 Myostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects.A cross ...
Der-Sheng Han +7 more
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Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide [PDF]
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2016 Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN ...
Sang Beum, Lee +4 more
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Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients. [PDF]
PLoS ONE, 2013 BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary ...
Astrid Breitbart +13 more
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