Results 11 to 20 of about 33,582 (263)
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Frontiers in Physiology, 2022 Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an ...
Mohd Hassan Baig +13 more
semanticscholar +5 more sources
Myostatin: A Skeletal Muscle Chalone
Annual Review of Physiology, 2022 Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β family member that acts as a master regulator of skeletal muscle mass.
Se-Jin Lee
semanticscholar +4 more sources
BMC Nutrition, 2022 Background Elevated concentrations of myostatin inhibit muscle growth, function and strength. Myostatin is a mediator of sarcopenia and is associated with insulin resistance.
Cydne A. Perry +2 more
doaj +2 more sources
Deciphering Myostatin’s Regulatory, Metabolic, and Developmental Influence in Skeletal Diseases
Frontiers in Genetics, 2021 Current research findings in humans and other mammalian and non-mammalian species support the potent regulatory role of myostatin in the morphology and function of muscle as well as cellular differentiation and metabolism, with real-life implications in ...
Catherine L. Omosule +2 more
doaj +2 more sources
Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication [PDF]
Journal of Biological Chemistry, 2017 Muscle and bone are closely associated in both anatomy and function, but the mechanisms that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted by muscles, has been shown to inhibit muscle growth, and the disruption ...
Bauman, William A. +10 more
core +2 more sources
Scientific Reports, 2021 The interactions of fibroblast-like synoviocyte (FLS)-derived pro-inflammatory cytokines/chemokines and immune cells support the recruitment and activation of inflammatory cells in RA. Here, we show for the first time that the classical myokine myostatin
Michelle Fennen +9 more
doaj +2 more sources
The journals of gerontology. Series A, Biological sciences and medical sciences, 2023 Over the past 25 years, considerable progress has been made in terms of elucidating the regulatory and signaling mechanisms underlying the control of skeletal muscle mass by myostatin and other secreted proteins belonging to the transforming growth ...
Se-Jin Lee +4 more
semanticscholar +1 more source
Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
Brain, behavior, and immunity, 2023 Pain is the most debilitating symptom of knee osteoarthritis (OA) that can even persist after total knee replacement. The severity and duration of pain do not correlate well with joint tissue alterations, suggesting other mechanisms may drive pain ...
Christian Martín Gil +6 more
semanticscholar +1 more source
Myostatin is associated with the presence and development of acute-on-chronic liver failure
JHEP Reports, 2023 Background & Aims Acute-on-chronic liver failure (ACLF) has been linked to different pathophysiological mechanisms, including systemic inflammation and mitochondrial dysfunction.
A. Ruiz-Margáin +14 more
semanticscholar +1 more source
Circulation, 2010 Cachexia in chronic heart failure (HF) is a major clinical problem that is still underestimated for its impact on morbidity, mortality, and healthcare expenditures. The pathophysiology of cardiac cachexia is characterized by a catabolic/anabolic imbalance.
Springer, Jochen +2 more
openaire +2 more sources