Results 21 to 30 of about 33,582 (263)
Cellular and Molecular Life Sciences, 2022 Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. In the past years, myostatin inhibition sparked interest among the scientific community for its potential to enhance muscle growth and to reduce, or even prevent ...
Elena Abati +3 more
semanticscholar +1 more source
Myostatin: Expanding horizons [PDF]
IUBMB Life, 2015 AbstractMyostatin is a secreted growth and differentiation factor that belongs to the TGF‐β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels ...
Sharma, Mridula +5 more
openaire +3 more sources
Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction.
Journal of Clinical Investigation, 2021 Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of skeletal muscle mass in 1997, there has been an extensive effort directed at understanding the cellular and physiological mechanisms underlying MSTN activity, with ...
Se-Jin Lee
semanticscholar +1 more source
Les Cahiers de Myologie, 2016 L’unique modele murin reproduisant la myopathie centronucleaire autosomique dominante associe a une mutation du gene dynamine -2 (KI-dnm2 R465W/+ ) reproduit la plupart des signes cliniques observes chez l’Homme, notamment une atrophie et une perte de force musculaire.
David Arnould, Anne-Cécile Durieux
openaire +1 more source
Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. [PDF]
PLoS ONE, 2011 The marked hypermuscularity in mice with constitutive myostatin deficiency reduces fat accumulation and hyperglycemia induced by high-fat feeding, but it is unclear whether the smaller increase in muscle mass caused by postdevelopmental loss of myostatin
Kerri Burgess +4 more
doaj +1 more source
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs
Endocrine reviews, 2021 Muscle wasting disease indications are among the most debilitating and often deadly noncommunicable disease states. As a comorbidity, muscle wasting is associated with different neuromuscular diseases and myopathies, cancer, heart failure, chronic ...
B. D. Rodgers, C. Ward
semanticscholar +1 more source
Biomolecules, 2020 Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size.
Juulia H. Lautaoja +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Background Associations between rheumatoid arthritis (RA) and reduced skeletal muscle have been studied, and we firstly reported myopenia independently predict one-year radiographic progression in RA.
Jian-Zi Lin +12 more
semanticscholar +1 more source
Serum myostatin is reduced in individuals with metabolic syndrome. [PDF]
PLoS ONE, 2014 Myostatin is a negative regulator of skeletal muscle mass and may also modulate energy metabolism secondarily. We aim to investigate the relationship between serum myostatin and the metabolic variables in diabetic (DM) and non-diabetic subjects.A cross ...
Der-Sheng Han +7 more
doaj +1 more source
Journal of Aging Research, 2022 Sarcopenia is common in hemodialysis patients, especially in the elderly patients undergoing hemodialysis. Various factors may contribute to the occurrence of sarcopenia, such as anabolic and catabolic imbalance.
Novira Widajanti +10 more
semanticscholar +1 more source