Results 31 to 40 of about 33,582 (263)

Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide [PDF]

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2016
Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN ...
Sang Beum, Lee, Jeong Hwan, Kim, Deuk-Hee, Jin, Hyung-Joo, Jin, Yong Soo, Kim   +4 more
openaire   +2 more sources

Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients. [PDF]

PLoS ONE, 2013
BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary ...
Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke   +13 more
doaj   +1 more source

Effect of Myostatin Gene Mutation on Slaughtering Performance and Meat Quality in Marchigiana Bulls

Animals, 2022
Simple Summary The aim of this work was the evaluation of slaughtering performance in a sample of 78 Marchigiana bulls with different allelic situation at the myostatin locus; in addition, the qualitative composition of meat samples collected from ...
S. Ceccobelli, F. Perini, M. Trombetta, S. Tavoletti, E. Lasagna, M. Pasquini   +5 more
semanticscholar   +1 more source

Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]

, 2014
Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora, Barreiro, Eshter, Chacon Cabrera, Alba, Diament, Miriam, Fermoselle, Clara, Mateu Jimenez, Mercè, Sandri, Marco, Urtreger, Alejandro Jorge   +7 more
core   +1 more source

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio, C. S. Mosteiro, D. l. Beiroa, F. F. Casanueva, I. Santos Zas, J. E. Viñuela, J. González Sánchez, J. M. Renaud, J. P. Camiña, J. Señarís, MORESI, Viviana, R. Gallego, R. Nogueiras, T. García Caballero, U. Gurriarán Rodríguez, W. Lin, Y. Pazos   +16 more
core   +1 more source

Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis

Developmental Biology, 2004
Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of Myostatin and Follistatin during chick development and show that they are expressed in the vicinity
Amthor, Helge, Nicholas, Gina, McKinnell, Iain, Kemp, C.Fred, Sharma, Mridula, Kambadur, Ravi, Patel, Ketan   +6 more
openaire   +3 more sources

Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.

Journal of Sports Science and Medicine, 2022
Resistance exercise (RE) activates cell signaling pathways associated with myostatin. Decorin is located in the extracellular matrix (ECM) and can block the inhibitory effect of myostatin.
D. Willoughby, T. Cardaci, Steven B. Machek, Dylan T. Wilburn, J. Heileson   +4 more
semanticscholar   +1 more source

High Myostatin Serum Related with High Prevalence of Sarcopenia Among Elderly Population in Pedawa Village, Bali, Indonesia

Indonesian Biomedical Journal, 2019
BACKGROUND: Sarcopenia is defined as a decrease in muscle mass accompanied by a decrease in muscle strength and performance. Sarcopenia arises from the disruption of the complex balance between anabolic and catabolic factors.
I Gusti Putu Suka Aryana, I Nyoman Astika, Raden Ayu Tuty Kuswardhani, Ida Bagus Putu Putrawan, Ni Ketut Rai Purnami, Wayan Giri Putra, Anak Agung Wiradewi Lestari, I Nyoman Wande   +7 more
doaj   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

Nutrients, 2020
Sarcopenia is a geriatric syndrome with a significant impact on older patients’ quality of life, morbidity and mortality. Despite the new available criteria, its early diagnosis remains difficult, highlighting the necessity of looking for a valid muscle ...
Jan Bączek, Marta Silkiewicz, Z. Wojszel   +2 more
semanticscholar   +1 more source