Results 31 to 40 of about 26,633 (217)

FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy

FEBS Open Bio, 2015
Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function.
Jen Y. Lee, Dede Lori, Dominic J. Wells, Paul R. Kemp   +3 more
doaj   +1 more source

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

Frontiers in Pharmacology, 2020
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao   +10 more
doaj   +1 more source

Sarcopenia from mechanism to diagnosis and treatment in liver disease [PDF]

, 2016
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes.
Dasarathy, Srinivasan, MERLI, Manuela
core   +1 more source

Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients

Critical Care, 2022
Background The objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care unit-acquired weakness (ICUAW).
Julius J. Grunow, Katja Reiher, Niklas M. Carbon, Lilian Jo Engelhardt, Knut Mai, Susanne Koch, Joerg C. Schefold, Werner Z’Graggen, Stefan J. Schaller, Jens Fielitz, Joachim Spranger, Steffen Weber-Carstens, Tobias Wollersheim   +12 more
doaj   +1 more source

Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes. [PDF]

Diabetes Obes Metab
Abstract Treatment with GLP‐1 receptor agonists (GLP‐1 RAs) is effective in reducing body weight in individuals with overweight and type 2 diabetes (T2D). However, measurements indicate that a considerable portion of the weight loss derives from fat‐free mass (FFM), including skeletal muscle, which may compromise metabolic health and physical function.
Aimelet V, Holst JJ.
europepmc   +2 more sources

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. [PDF]

, 2012
The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators
Seldin, Marcus M, Wong, G William
core   +1 more source

Deciphering Myostatin’s Regulatory, Metabolic, and Developmental Influence in Skeletal Diseases

Frontiers in Genetics, 2021
Current research findings in humans and other mammalian and non-mammalian species support the potent regulatory role of myostatin in the morphology and function of muscle as well as cellular differentiation and metabolism, with real-life implications in ...
Catherine L. Omosule, Charlotte L. Phillips, Charlotte L. Phillips   +2 more
doaj   +1 more source

Geometric control of myogenic cell fate. [PDF]

, 2006
This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells.
Conboy IM, Disatnik MH, Elena M de Juan-Pardo, Irina M Conboy, Massague J, Mike Bao-Trong Hoang, Miller KJ, Partridge TA, Seale P, Tidball JG   +9 more
core   +3 more sources

Quadriceps myostatin expression in COPD [PDF]

European Respiratory Journal, 2010
To the Editors: Quadriceps muscle dysfunction is well recognised in chronic obstructive pulmonary disease (COPD), and is associated with impaired exercise capacity and increased mortality 1. Functionally, the quadriceps is characterised by reduced strength, increased fatigability and decreased endurance, associated with muscle fibre atrophy and a ...
W D-C, Man, S A, Natanek, J, Riddoch-Contreras, A, Lewis, G S, Marsh, P R, Kemp, M I, Polkey   +6 more
openaire   +2 more sources

Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p

Frontiers in Immunology, 2017
Rheumatoid arthritis (RA) is characterized by the infiltration of a number of pro-inflammatory cytokines into synovial fluid and patients with RA often develop joint destruction and deficits in muscle mass.
Sung-Lin Hu, Sung-Lin Hu, An-Chen Chang, Chien-Chung Huang, Chien-Chung Huang, Chun-Hao Tsai, Chun-Hao Tsai, Cheng-Chieh Lin, Cheng-Chieh Lin, Cheng-Chieh Lin, Chih-Hsin Tang, Chih-Hsin Tang, Chih-Hsin Tang   +12 more
doaj   +1 more source