Results 201 to 210 of about 2,964 (225)
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Myotoxin a, Crotamine and Defensin Homologs in Reptile Venoms
2021Snakebite envenomation is common in all inhabited continents of the world, with more than 100,000 fatalities occurring every year. Depending on the snake species involved, envenomation includes often disabling intense local tissue damage with inflammation, pain and myonecrosis, caused in part by molecules known as myotoxins.
Porta, Lucas C +3 more
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Purification and properties of a myotoxin from Conus geographus venom
Archives of Biochemistry and Biophysics, 1978Abstract Previous studies (R. Endean et al. (1974), Toxicon12: 131–138) indicate that whole venom from the marine mollusc Conus geographus directly inhibits skeletal muscle, leaving peripheral nerves, cardiac and smooth muscle unaffected. A quantitative bioassay has been used to detect and measure biologically active myotoxin. By using chromatography
L J, Cruz, W R, Gray, B M, Olivera
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Lys49 phospholipase A2 myotoxins lyse cell cultures by two distinct mechanisms
Toxicon, 1998Three Lys49 phospholipase A2 (PLA2) myotoxins from Agkistrodon contortrix laticinctus (ACLMT), Bothrops jararacussu (bothropstoxin-I) and Bothrops asper (myotoxin II) snake venoms are enzymatically inactive on artificial substrates, yet addition of these toxins to cell cultures causes the release of fatty acids derived from the hydrolysis of membrane ...
J E, Fletcher, M S, Jiang
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Purification of a myotoxin from the toadfish Thalassophryne maculosa (Günter) venom
Toxicon, 2005Venom was milked by gently pressing the base of the opercular and dorsal fin spines. Three fractions were obtained by molecular exclusion high pressure liquid chromatography (HPLC) (Protein Pak 125SW, Millipore Corporation) column, but only the last one with 22.7 min retention time (rt) was biological active (TmPP-22.7).
J I, Sosa-Rosales +4 more
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Similarities and differences in mechanisms of cardiotoxins, melittin and other myotoxins
Toxicon, 1996Myonecrosis induced in vivo by cardiotoxin, melittin, and Asp49 and Lys49 phospholipase A2 (PLA2) myotoxins involves rapid lysis of the sarcolemma, myofibril clumping, and hypercontraction of sarcomeres. In contrast, skeletal muscle necrosis induced by crotamine and myotoxin a is much slower, consisting of mitochondrial and sarcoplasmic reticulum ...
J E, Fletcher +4 more
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A common cytolytic region in myotoxins, hemolysins, cardiotoxins and antibacterial peptides*
International Journal of Peptide and Protein Research, 1989Several proteins and polypeptides of reptilian, amphibian, insect, and microbial origin share a common cytolytic property. However, these cytolysins fulfill different objectives. They provide offensive armament in the case of toxins, but defensive systems in the case of antibacterial peptides.
R M, Kini, H J, Evans
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Renal toxicity of Bothrops moojeni snake venom and its main myotoxins
Toxicon, 2002Acute renal failure is one the most common systemic complications after snakebite, however, its pathogenesis remains obscure. In this study we evaluated the renal effects of Bothrops moojeni venom and its myotoxins (Bmtx-I and BmtxII) in rat isolated perfused kidneys.
P S F, Barbosa +9 more
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Natural phospholipase A2 myotoxin inhibitor proteins from snakes, mammals and plants
Toxicon, 2003A renewed interest in the phenomenon of inter- and intra-species resistance towards the toxicity of snake venoms, coupled with the search for new strategies for treatment of snake envenomations, has prompted the discovery of proteins which neutralize the major toxic components of these venoms.
Sergio, Lizano +2 more
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LOCAL ANESTHETICS ARE POTENT MYOTOXINS
Southern Medical Journal, 1999Radoslav Kosanin, Verne Lanier
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