Results 131 to 140 of about 4,101 (195)

Safety evaluation of a recombinant myxoma-RHDV virus inducing horizontal transmissible protection against myxomatosis and rabbit haemorrhagic disease

, 2000
We have recently developed a transmissible vaccine to immunize rabbits against myxomatosis and rabbit haemorrhagic disease based on a recombinant myxoma virus (MV) expressing the rabbit haemorrhagic disease virus (RHDV) capsid protein [Barcena et al ...
Pagès-Manté, A., Espuña, E., Morales, Mónica, Bárcena, Juan, Torres, Juan María, Vázquez, B., Sánchez-Vizcaíno, J. M., Ramírez, Miguel Ángel   +7 more
core   +1 more source

Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo

, 2005
The M128L myxoma virus gene expresses a five-membrane spanning cell surface protein with significant amino acid homology to the cellular CD47 proteins.
C.M. Cameron, A. Lucas, M. Mann, Mann, M., McFadden, Grant, J.W. Barrett, Barrett, J.W., Cameron, C.M., Lucas, A., Grant McFadden   +9 more
core   +1 more source

Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance. [PDF]

Cancer Cell, 2022
Zheng N, Fang J, Xue G, Wang Z, Li X, Zhou M, Jin G, Rahman MM, McFadden G, Lu Y.   +9 more
europepmc   +1 more source

Mouse guanylate-binding proteins of the chromosome 3 cluster do not mediate antiviral activity in vitro or in mouse models of infection

Communications Biology
Dynamin-like GTPase proteins, including myxoma (Mx) and guanylate-binding proteins (GBPs), are among the many interferon stimulated genes induced following viral infections.
Melkamu B. Tessema, Shouya Feng, Daniel Enosi Tuipulotu, Rubaiyea Farrukee, Chinh Ngo, Catarina Gago da Graça, Masahiro Yamomoto, Daniel T. Utzschneider, Andrew G. Brooks, Sarah L. Londrigan, Si Ming Man, Patrick C. Reading   +11 more
doaj   +1 more source

Combination of LIGHT (TNFSF14)-Armed Myxoma Virus Pre-Loaded into ADSCs and Gemcitabine in the Treatment of Experimental Orthotopic Murine Pancreatic Adenocarcinoma. [PDF]

Cancers (Basel), 2022
Jazowiecka-Rakus J, Sochanik A, Hadryś A, Fidyk W, Chmielik E, Rahman MM, McFadden G.   +6 more
europepmc   +1 more source

Identifying Cell Death Pathways Activated by Myxoma virus in Melanoma

, 2019
: Melanoma is a type of skin cancer that can metastasize in advanced stages to other organs such as the brain, lymph nodes, lungs and liver. Current standard treatment options include surgery, radiation therapy, chemotherapy, and immunotherapy.

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Systemic Delivery of mLIGHT-Armed Myxoma Virus Is Therapeutic for Later-Stage Syngeneic Murine Lung Metastatic Osteosarcoma. [PDF]

Cancers (Basel), 2022
Christie JD, Appel N, Zhang L, Lowe K, Kilbourne J, Daggett-Vondras J, Elliott N, Lucas AR, Blattman JN, Rahman MM, McFadden G.   +10 more
europepmc   +1 more source

Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages. [PDF]

PLoS Pathog, 2022
Conrad SJ, Raza T, Peterson EA, Liem J, Connor R, Nounamo B, Cannon M, Liu J.   +7 more
europepmc   +1 more source

The Oncolytic Activity of Myxoma Virus against Soft Tissue Sarcoma Is Mediated by the Overexpression of Ribonucleotide Reductase. [PDF]

Clin Med Insights Oncol, 2021
Woo Y, Warner SG, Geha R, Stanford MM, Decarolis P, Rahman MM, Singer S, McFadden G, Fong Y.   +8 more
europepmc   +1 more source

Conserved Surface-Exposed K/R-X-K/R Motifs and Net Positive Charge on Poxvirus Complement Control Proteins Serve as Putative Heparin Binding Sites and Contribute to Inhibition of Molecular Interactions with Human Endothelial Cells: a Novel Mechanism for Evasion of Host Defense

, 2000
Vaccinia virus complement control protein (VCP) has been shown to possess the ability to inhibit both classical and alternative complement pathway activation.
Shchelkunov, SN, Reynolds, DN, Kotwal, GJ, Justus, DE, Srisatjaluk, R, Loparev, VN, Totmenin, AV, Keeling, KL, Smith, SA, Parkinson, J, Barlow, PN, Mullin, NP   +11 more
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