Pharmacokinetics of N,N-dimethyltryptamine in Humans. [PDF]
Eur J Drug Metab Pharmacokinet, 2023 N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects.The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile ...
Good M +11 more
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Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience [PDF]
Scientific Reports, 2022 Understanding the phenomenology and content of the inhaled N, N, dimethyltryptamine (N, N-DMT) experience is critical to facilitate and support ongoing research and therapeutic models targeting mental health conditions and central nervous system ...
David Wyndham Lawrence +3 more
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N,N-dimethyltryptamine and Amazonian ayahuasca plant medicine. [PDF]
Hum Psychopharmacol, 2022 AbstractObjectiveReports have indicated possible uses of ayahuasca for the treatment of conditions including depression, addictions, post‐traumatic stress disorder, anxiety and specific psychoneuroendocrine immune system pathologies. The article assesses potential ayahuasca and N,N‐dimethyltryptamine (DMT) integration with contemporary healthcare.
James E +3 more
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N,N‐dimethyltryptamine affects electroencephalography response in a concentration‐dependent manner—A pharmacokinetic/pharmacodynamic analysis [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 N,N‐dimethyltryptamine (DMT) is a psychedelic substance and is being used as a research tool in investigations of the neurobiology behind the human consciousness using different brain imaging techniques.
Emma Eckernäs +4 more
doaj +2 more sources
Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) [PDF]
Communications BiologyThe transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from
Juan Ignacio Piccinini +8 more
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Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics [PDF]
Frontiers in PsychiatryGraphical ...
Cristiano Chaves +10 more
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Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways [PDF]
Scientific ReportsReward processing is a broad psychological construct that can be parsed into distinct components known as “reinforcement learning” (learning), “reward responsiveness” (liking), and “motivation to obtain a reward” (wanting).
Gisela Lima +6 more
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Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N‐dimethyltryptamine – Implications for dose considerations [PDF]
Clinical and Translational Science, 2022 N,N‐dimethyltryptamine (DMT) is a psychedelic compound that is believed to have potential as a therapeutic option in several psychiatric disorders. The number of clinical investigations with DMT is increasing.
Emma Eckernäs +4 more
doaj +2 more sources
Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence [PDF]
Frontiers in Psychiatry, 2022 BackgroundThe psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as “reactivations” (similar to “flashbacks”) is a poorly understood and frequently reported
Ana María Ortiz Bernal +4 more
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Optimized infusion rates for N,N‐dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 N,N‐dimethyltryptamine (DMT) is a psychedelic compound that is being studied as a therapeutic option in various psychiatric disorders. Due to its short half‐life, continuous infusion of DMT has been proposed to extend the psychedelic experience and ...
Emma Eckernäs +5 more
doaj +2 more sources