Results 91 to 100 of about 13,568,693 (193)

Enlightening the “Spirit Molecule”: Photomodulation of the 5‐HT(2A) Receptor by a Light‐Controllable N,N‐Dimethyltryptamine Derivative

, 2022
Classical psychedelics are a group of hallucinogens which trigger non‐ordinary states of consciousness through activation of the 5‐HT(2A) receptor (5‐HT(2A)R) in the brain.
Decker, Michael, Gerwe, Hubert, He, Feng, Stove, Christophe, Pottie, Eline   +4 more
core   +1 more source

Therapeutic properties of ayahuasca component N,N-Dimethyltryptamine in a pre-clinical model of Parkinson's disease

Parkinson's disease is a progressive neurodegenerative disorder with increasing global prevalence, primarily driven by population ageing. A hallmark of the disease is the degeneration of nigrostriatal dopaminergic neurons, accompanied by marked ...
Giné Domínguez, Elena, López Moreno, José Antonio, Alonso Gil, Sandra, Echeverry Alzate, Víctor, Buhler, Kora Mareen Katharina, Morales García, José Ángel, Calleja Conde, Javier, Sanz SanCristobal, Marina, Pérez Castillo, Ana   +8 more
core   +1 more source

Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

Acta Pharmaceutica Sinica B, 2016
We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia.
Xi-Ling Jiang, Hong-Wu Shen, Donald E. Mager, Stephan Schmidt, Ai-Ming Yu   +4 more
doaj   +1 more source

Lysergic acid diethylamide (LSD) and N,N-dimethyltryptamine (DMT) as peroxidases substrates: a possible metabolization pathway

, 2008
Após um intervalo de duas décadas, ressurgiu um novo interesse em estudos sobre alucinógenos que visam a compreensão de como estes compostos interagem com o sistema nervoso central (SNC).
Gomes, Melissa Medrano, Melissa Medrano Gomes   +1 more
core   +1 more source

Endogenous Biosynthesis and Neural Correlates of N,N-dimethyltryptamine

, 2023
N,N-dimethyltryptamine (DMT) belongs to a class of drugs known as serotonergic psychedelics, which produce profound shifts in consciousness by dramatically altering perception and causing hallucinatory phenomena.
Glynos, Nicolas
core   +1 more source

Effects of DMT on mental health outcomes in healthy volunteers

Scientific Reports
Psilocybin, a serotonergic psychedelic, is being increasingly researched in clinical studies for the treatment of psychiatric disorders. The relatively lengthy duration of oral psilocybin’s acute effects (4–6 h) may have pragmatic and cost-effectiveness ...
Christopher Timmermann, Richard J. Zeifman, David Erritzoe, David J. Nutt, Robin L. Carhart-Harris   +4 more
doaj   +1 more source

Quantitative Analysis of Substituted -Dimethyl-tryptamines in the Presence of Natural Type XII Alkaloids

Natural Product Communications, 2012
This paper reports the qualitative and quantitative analysis (QA) of mixtures of hallucinogens, N,N -dimethyltryptamine (DMT) ( 1 ), 5-methoxy- ( 1a ) and 5-hydroxy- N,N -dimethyltryptamine ( 1b ) in the presence of β-carbolines (indole alkaloids of type
Bojidarka Ivanova, Michael Spiteller
doaj   +1 more source

N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk

Alzheimer’s Research & Therapy
Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD).
Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang, Zhang-Jin Zhang   +5 more
doaj   +1 more source

A Fully Validated LC-MS Quantitation Method for Psychoactive Compounds Found in Native South American Plant Species

Psychoactives
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior.
Jonathan Tran, Aaron C. Elkins, Simone Vassiliadis, Noel O. I. Cogan, Simone J. Rochfort   +4 more
doaj   +1 more source

A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting

, 2020
Background: suggests therapeutic potential 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). However, online anecdotal reports have described a phenomenon following cessation of the acute effects of 5-MeO-DMT use which has been termed reactivation (i.e., re ...
A. K. Davis, Malin V. Uthaug, A. M. Ortiz Bernal, R. Lancelotta, Ramaekers, J.G., Davis, A.K., Lancelotta, R., Johannes G. Ramaekers, Uthaug, M.V., Bernal, A.M.O.   +9 more
core   +1 more source