Results 101 to 110 of about 13,568,693 (193)

Single-dose DMT reverses anhedonia and cognitive deficits via restoration of neurogenesis in a stress-induced depression model

Translational Psychiatry
Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) has shown rapid antidepressant effects in early ...
Rafael V. Lima da Cruz, Rêmullo B. G. de Miranda Costa, Gabriel M. de Queiroz, Tijana Stojanovic, Thiago C. Moulin, Richardson N. Leão   +5 more
doaj   +1 more source

Pharmacology and Therapeutic Potential of N,N-Dimethyltryptamine: Ischemia-Related Application

This thesis explores the therapeutic potential of N,N-Dimethyltryptamine (DMT), a naturally occurring psychedelic compound known for its intense but short-lasting psychoactive effects.
Aghapour Olilo, Benyamin
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Study of the indoleamine 2,3-dioxygenase inhibitory action by tryptamine (TRY) and N,N-dimethyltryptamine (DMT)

, 2012
A enzima indolamina 2,3-dioxigenase (IDO) é responsável pela degradação de triptofano (TRP) pela via das quinureninas. O aumento da expressão de IDO é a grande responsável pela resposta de tolerância imunológica e pode ser induzida por IFN-γ e ...
Melissa Cavalheiro Tourino, Tourino, Melissa Cavalheiro   +1 more
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Parapsychology, N, N-Dimethyltryptamine and the Pineal Gland

, 2019
In the last decades, one of the psychedelic substances which has gained high attention for its implications in several para-psychological phenomena (including out-of-body states, deep changes in sensory perception, mood, and thought, travels in ...
Bragazzi, Nicola Luigi, Khabbache, Hicham, Neri, Bruno, Simões, Mário, Perduca, Marco, Zerbetto, Riccardo, Re, Tania Simona, Penazzi, Gabriele, Firenzuoli, Fabio   +8 more
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Predicting drug–drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling

Frontiers in Molecular Biosciences
IntroductionAyahuasca is a psychedelic preparation containing N,N-dimethyltryptamine (DMT) and the β-carboline harmine (HRM), a reversible monoamine oxidase A inhibitor that enables DMT oral bioavailability.
Gabriella de Souza Gomes Ribeiro, Beatriz Aparecida Passos Bismara Paranhos, Fabiane Dörr, Maurício Yonamine, Bianca Villanova, Lorena Terene Lopes Guerra, Adrieli Oliveira Raminelli, Jose Augusto Silva Reis, Caio Cesar de Paula, Anna Beatriz Vicentini Zacharias, Jaime Eduardo Cecílio Hallak, Jaime Eduardo Cecílio Hallak, Rafael Guimarães dos Santos, Rafael Guimarães dos Santos, Frederico Severino Martins, Tania Marcourakis   +15 more
doaj   +1 more source

Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults

Scientific Reports
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported ...
Anna O. Ermakova, Fiona Dunbar, Mathieu Seynaeve, Raphaël Millière   +3 more
doaj   +1 more source

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine (DMT)

Journal of Cognitive Neuroscience
Abstract N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear.
Lewis-Healey, Evan, Pallavicini, Carla, Cavanna, Federico, D'Amelio, Tomas, De La Fuente, Laura Alethia, Copa, Debora, Müller, Stephanie, Bruno, Nicolas, Tagliazucchi, Enzo, Bekinschtein, Tristan   +9 more
openaire   +3 more sources

Safety and tolerability profile of N,N-Dimethyltryptamine: a systematic review of clinical trials

N,N-Dimethyltryptamine (DMT) is presently emerging as a candidate in clinical trials aimed at addressing treatment-resistant depression. This condition is characterized by its chronic and incapacitating nature, featuring heightened severity and prolonged
Wiesław Jerzy Cubała, Damian Świeczkowski, Aleksander Kwaśny   +2 more
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Vigilance state dissociation induced by 5-MeO-DMT in mice

Communications Biology
Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of vigilance.
Benjamin J. B. Bréant, José Prius Mengual, Alexander Andrews, Anna Hoerder-Suabedissen, Jasmin Patel, David M. Bannerman, Trevor Sharp, Vladyslav V. Vyazovskiy   +7 more
doaj   +1 more source

Human psychopharmacology of N,N-dimethyltryptamine

, 1996
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures.
Strassman, Rick J
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