Results 111 to 120 of about 13,568,693 (193)

5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats

Scientific Reports
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects.
Annie C. Souza, Bryan C. Souza, Arthur França, Marzieh Moradi, Nicholy C. Souza, Katarina E. Leão, Adriano B. L. Tort, Richardson N. Leão, Vítor Lopes-dos-Santos, Sidarta Ribeiro   +9 more
doaj   +1 more source

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community

Harm Reduction Journal
Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This
Daniel J. Kruger, Gina Mersereau, Ashley Sullivan, Julie Barron, Moss Herberholz, Niloufar Pouyan, Jacob S. Aday, Kevin F. Boehnke   +7 more
doaj   +1 more source

Psychedelic Therapy: A Primer for Primary Care Clinicians—5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT)

Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), also officially known as Mebufotenin, is a naturally occurring serotonergic psychedelic alkaloid found in the venom of the Sonoran Desert toad (Incilius alvarius) and various plant species ...
Owen S. Muir, Mathieu Seynaeve, Shiven Chaudhry, Kenneth Shinozuka, Burton J. Tabaac, Anne Weisman   +5 more
core  

Antinociceptive effect of N,N-dimethyltryptamine (DMT) involving serotonergic, opioidergic, cannabinoidergic, and nitrergic systems in PGE2-induced hyperalgesia in rats

1. Dos Santos RG, Hallak JEC. Ayahuasca: pharmacology, safety, and therapeutic effects. CNS Spectr. 2024 Nov 20;30(1):e2. 2. Bouso JC, González D, Fondevila S, Cutchet M, Fernández X, Ribeiro Barbosa PC, et al.
Flávia C.S. Fonseca, Daniel P.D. Machado, Igor D.G. Duarte, André D. Cavalcante, Andrea C. Perez, Thiago R.L. Romero   +5 more
core   +1 more source

A Systematic Review of the Neural Correlates and the Psychedelic Experience Induced by Ayahuasca and N, N-Dimethyltryptamine (DMT)

, 2022
Background: Ayahuasca is a South American psychoactive brew that contains Dimethyltryptamine (DMT) and monoamine oxidase inhibitors (MAOIs). Research has experienced a resurgence of interest in exploring the potential of these substances in the last decade. Thus, the aim of this review was to systematically review studies that used a placebo-controlled
openaire   +1 more source

Dose response and time course effects off N,N-dimethyltryptamine on dissruption of rat shuttlebox avoidance

, 1977
N,N-Dimethyltryptamine (DMT) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (Fisher 344/Mai) who were trained to a high, stable base line of conditioned avoidance responding in the ...
E.A. Moja, R. J. Wyatt, J. C. Gillin, D. M. Stoff   +3 more
core   +1 more source

N,N-Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area I_h-Negative Neurons Alters the Firing Rate and Conductance in a Sex-Dependent Manner. [PDF]

J Neurochem
Eliasen JN, Rezagholizadeh A, Jacobsen HP, Kohlmeier KA.   +3 more
europepmc   +1 more source

Phenomenology of N,N-Dimethyltryptamine use : a thematic analysis

, 2008
Phenomenology of N,N-Dimethyltryptamine use : a thematic ...
Adam Rock (13050294), Christopher Cott (13064136)   +1 more
core  

Synthetic Studies Toward the Marine Alkaloid Convolutindole a, a Structurally Remarkable Derivative of the Hallucinogen N,N-Dimethyltryptamine (Dmt)

Tetrahedron Letters, 2023
Karen Ichikawa, Jessica C. Neville, Yihan Yu, Jonathan Sperry   +3 more
openaire   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial. [PDF]

Clin Transl Sci
van der Heijden KV, Zuiker RGJA, Otto ME, Bryan CS, Stewart N, Stillwell C, De Kam ML, van Leuken MB, van Gerven JMA, Jacobs GE.   +9 more
europepmc   +1 more source