Results 91 to 100 of about 14,619 (195)
Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1336-1344, March 2026.ABSTRACT Purpose The purpose of this study was to investigate the effect of magnetization exchange on the measurement of tryptophan and NAD+ T1 relaxation times and to determine the magnetization exchange rates with a two‐spin system model using downfield 1H MRS spectroscopy at 7 T in human brain.
Sophia Swago +5 more
wiley +1 more source
Neurobiology of Disease, 2001 There is substantial evidence for bioenergetic defects in Huntington's disease (HD). Creatine administration increases brain phosphocreatine levels and it stabilizes the mitochondrial permeability transition.
Ole A. Andreassen +12 more
doaj +1 more source
Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results [PDF]
, 2009 *Aim*: Metabolite concentrations by in vivo magnetic resonance spectroscopy and ex vivo NMR spectroscopy were compared with excised normal human tissue relaxation times and tissue homogenate contents. *Hypothesis*: Biochemical analysis
Arun Agrawala +2 more
core +1 more source
Multimodal MRI as a diagnostic biomarker for amyotrophic lateral sclerosis [PDF]
, 2014 Objective Reliable biomarkers for amyotrophic lateral sclerosis ( ALS ) are needed, given the clinical heterogeneity of the disease. Here, we provide proof‐of‐concept for using multimodal magnetic resonance imaging ( MRI ) as a diagnostic biomarker for
Barker, Peter B. +10 more
core +1 more source
Band‐Selective IR PRESS for Brain Tumor Spectroscopy Allows Robust Detection of Lactate
NMR in Biomedicine, Volume 39, Issue 3, March 2026.Lactate quantification by MRS is hindered by lipid signal overlap at 1.3 ppm, frequently forcing the use of long echo times that suppress other metabolites. We developed SPIR‐PRESS, a selective inversion recovery technique that suppresses lipids while preserving metabolite sensitivity.
Shun Kishimoto +12 more
wiley +1 more source
Serial Whole-Brain N-Acetylaspartate Concentration in Healthy Young Adults [PDF]
American Journal of Neuroradiology, 2007 Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults.
Rigotti, D. J. +7 more
openaire +3 more sources
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans. [PDF]
PLoS ONE, 2013 In Multiple Sclerosis (MS) the relationship between disease process in normal-appearing white matter (NAWM) and the development of white matter lesions is not well understood.
Anders Tisell +6 more
doaj +1 more source
, 2005 Canavan disease (CD) is an autosomal recessive disorder, characterized by spongiform degeneration of the white matter of the brain. Aspartoacylase (ASPA) hydrolyses N-acetylaspartic acid to aspartate and acetate.
Surendran, Sankar
core
NMR in Biomedicine, Volume 39, Issue 3, March 2026.We use synthetic (Aim 1), human brain (Aim 2) and phantom (Aim 3) data to assess how basis set choice affects Glu, tCr, tNAA and tCho quantification, focusing on the bias–variance trade‐off under varying SNR conditions. Including GABA, GSH, NAAG and glucose improved Glu estimates, reducing bias and variance below 10%.
Polina Emeliyanova +3 more
wiley +1 more source
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment [PDF]
, 2014 Objective(s): HIV-associated neurocognitive disorders (HAND) remain prevalent in HIV-infected patients on antiretroviral therapy (ART), but the underlying mechanisms are unclear. Some features of HAND resemble those of age-associated cognitive decline in
Cassol, Edana +4 more
core +1 more source