Results 141 to 150 of about 47,831 (279)

Use of N-acetylcysteine as treatment adjuvant regulates immune response in visceral leishmaniasis: Pilot clinical trial and in vitro experiments

, 2022
Lucas Sousa Magalhães, Enaldo Vieira de Melo, Nayra P. Damascena, Adriana Cardoso Batista Albuquerque, Camilla Natália Oliveira Santos, Mônica Cardozo Rebouças, Mariana de Oliveira Bezerra, Ricardo Luís Louzada da Silva, Fabrícia Alvisi de Oliveira, Priscila Lima dos Santos, João S. Silva, Michael W. Lipscomb, Ângela Maria da Silva, Amélia Ribeiro de Jesus, Roque Pacheco de Almeida   +14 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Effects of topically applied liquid N-acetylcysteine for the management of burning mouth syndrome. [PDF]

Sci Rep
Kim JW, Won HR, Kim CS, Choi JS, Woo SH, Lee DW, Kwon M, Joo YH, Koo BS, Cho KJ.   +9 more
europepmc   +1 more source

Systematic Review of Human and Animal Studies Examining the Efficacy and Safety of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) in Traumatic Brain Injury: Impact on Neurofunctional Outcome and Biomarkers of Oxidative Stress and Inflammation

, 2018
Junaid A. Bhatti, Barto Nascimento, Umbreen Akhtar, Shawn G. Rhind, Homer Tien, Avery B. Nathens, Luís Teodoro da Luz   +6 more
openalex   +1 more source

In‐Tumor CRISPR‐Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma

Cancer Science, EarlyView.
We conducted an in vivo genome‐wide CRISPR‐Cas9 knockout screen using MTMCT‐derived cells to identify genes essential for tumor growth. SOD1 emerged as a key therapeutic target, and its inhibition suppressed tumor proliferation by disrupting redox homeostasis, both in vitro and in PDX models. ABSTRACT Malignant transformation of mature cystic teratoma (
Satoshi Tamauchi, Kosuke Yoshida, Wang Xinyuan, Atsushi Nakagawa, Akira Yokoi, Nobuhisa Yoshikawa, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama   +8 more
wiley   +1 more source

Reversing Alcohol-Dependent Effects on HIV Replication: Are There Roles for Pioglitazone and N-acetylcysteine? [PDF]

Am J Respir Cell Mol Biol
Manicone AM, Brune JE.
europepmc   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Evaluation of cut-off values in acute paracetamol poisoning for safe termination of N-acetylcysteine. [PDF]

BMC Pharmacol Toxicol
Lim J, Cha K.
europepmc   +1 more source

Evaluation of the Safety and Efficacy of N-acetylcysteine in the Prevention of Paclitaxel-induced Peripheral Neuropathy: A Randomized, Double-blind, and Placebo-controlled Trial

, 2018
AliMohammad Sabzghabaee, Nastaran Eizadi‐Mood, R Ahmadi, Sara Babazadeh, Ahmad Yaraghi, Massoumeh Sadeghi, Payam Peymani, Amir Mohammad Shabani, Ebrahim Salehifar   +8 more
openalex   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source