Results 161 to 170 of about 47,831 (279)

Metabolic Stroke: Atypical Presentation of Succinic Semialdehyde Dehydrogenase Deficiency

open access: yesJIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessive neurometabolic disorder caused by biallelic pathogenic variants in ALDH5A1, encoding the mitochondrial enzyme SSADH. This enzyme catalyses the conversion of succinic semialdehyde to succinic acid in the γ‐aminobutyric acid (GABA) degradation pathway.
Sharmila Kiss   +10 more
wiley   +1 more source

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

open access: yesQuantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono   +4 more
wiley   +1 more source

Pterygium: Glutathione, Nitric Oxide Production and N-Acetylcysteine Treatment [PDF]

open access: green, 2019
Fidelina Parra   +7 more
openalex   +1 more source

Feasibility and Safety of Argon Cold Plasma Use as an Adjunctive Treatment for Corneal Disease in Dogs, Cats and Small Mammals: A Prospective Clinical Study

open access: yesVeterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Objective Evaluation of the feasibility of argon cold plasma (ACP) use in corneal diseases in clinical practice and assessment of short‐ and long‐term safety in dogs, cats, and small mammals. Animals Studied Client‐owned animals. Procedure ACP was performed in animals with corneal diseases using the kINPenVET (Neoplas GmbH, Germany) under ...
Petr Soukup, Ingrid Allgoewer
wiley   +1 more source

N-Acetylcysteine Amide Is a Potential Novel Radioprotector of Salivary Gland Function. [PDF]

open access: yesCancers (Basel)
Ritter A   +8 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang   +15 more
wiley   +1 more source

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