Results 111 to 120 of about 1,001,057 (271)

N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)

Frontiers in Immunology, 2019
The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota, Cesare Galli, Cesare Galli   +2 more
doaj   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice

Food Frontiers, Volume 7, Issue 2, March 2026.
Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou, Ye Wang, Yan‐Ling Kang, Bushra Walayat, Bin‐Qi Rui, Qi‐Di Xue, Xi He, Jing‐Yu Yan, Yin‐Hui Liu, Ming Li   +9 more
wiley   +1 more source

Synthesis of Molecularly Imprinted Polymerand its Molecular Recognition Propertiesof N-Acetylneuraminic Acid

E-Journal of Chemistry, 2007
A molecular imprinting technique was applied in this work to detect N-acetylneuraminic acid (Neu5Ac) and its analogue structure. Twomolecularly imprinted polymers (MIP) were prepared using Neu 5Ac as the template molecule, as well as methacrylic acid ...
Hsin-Hung Pan, Wen-Chien Lee, Chin-Yin Hung, Ching-Chiang Hwang   +3 more
doaj   +1 more source

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. [PDF]

, 2019
Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer1. In Western diets, red meat is a frequently eaten food2, but long-term consumption has been associated with ...
Alisson-Silva, Frederico, Chang, Geoffrey, Chuzel, Léa, Diaz, Sandra L, Ganatra, Mehul B, Huang, Jianbo, Martino, Cameron, Rees, Steven D, Secrest, Patrick, Siegel, Dionicio, Taron, Christopher H, Varki, Ajit, Zaramela, Livia S, Zengler, Karsten, Zuñiga, Cristal   +14 more
core  

Law of Genome Evolution Direction : Coding Information Quantity Grows

, 2008
The problem of the directionality of genome evolution is studied. Based on the analysis of C-value paradox and the evolution of genome size we propose that the function-coding information quantity of a genome always grows in the course of evolution ...
A. F. A. Smit, A. G. Matera, A. Mira, B. Charlesworth, C. L. Organ, C. Nusbaum, D. A. Petrov, D. L. Marais Des, D. R. Scannell, E. Schrodinger, E. T. Dermitzakis, F. Clark, G. Bejerano, G. Liu, G. Storz, H. H. Chou, H. H. Kazazian, H. Ozkan, H. Winter, I. J. Leitch, I. Wapinski, I. Wickelgren, International Human Genome Sequencing Consortium, J. Filkowski, J.M. Aury, K. M. Devos, L. F. Luo, L. F. Luo, L. F. Luo, L. He, L. Patthy, L. R. Zhang, Liao-fu Luo, R. J. Taft, R. P. Bininda-Edmonds, S. E. Peters, T. C. Stadtman, T. Kouzarides, T. R. Gregory, The ENCODE Project Consortium, W. Deng, W. Enard, W. H. Li, W. Makalowski, X. Xu   +44 more
core   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

N-Acetylneuraminic Acid Inhibits Melanogenesis via Induction of Autophagy

Cosmetics
N-acetylneuraminic acid (Neu5Ac) is the predominant form of sialic acid present in the glossy swiftlet (Collocalia esculenta). It is also the only form of sialic acid detected in the human body.
Kei Yoshikawa, Kazuhisa Maeda
doaj   +1 more source

Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity [PDF]

, 2013
The microbiomes in the gastrointestinal tract (GIT) of individuals receiving antibiotics and those in obese subjects undergo compositional shifts, the metabolic effects and linkages of which are not clearly understood. Herein, we set to gain insight into
Artacho, Alejandro, Bargiela, Rafael, Campoy, Cristina, Ferrer, Manuel, Friedrichs, Anette, Gosalbes Soler, María José, Hernández, Ester, Knecht, Henrik, Latorre, Amparo, Martins dos Santos, Vitor A. P., Martínez-Martínez, Mónica, Moya, Andrés, Ott, Stephan J., Pérez-Cobas, Ana Elena, Ruiz, Alicia, Seifert, Jana, Suárez Díez, María, Suárez, Antonio, von Bergen, Martin   +18 more
core   +1 more source

In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation. [PDF]

, 1990
After growth of gonococci in the presence of cytidine monophospho-N-acetyl-neuraminic acid (CMP-NANA), their 4.5-kD lipooligosaccharide (LOS) component was increased by approximately 400 daltons, whereas the LOS of strains lacking the 4.5-kD component ...
Apicella, MA, Cole, JA, Griffiss, JM, Lesse, AJ, Mandrell, RE, Morse, SA, Parsons, NJ, Shero, M, Smith, H, Sugai, JV   +9 more
core   +1 more source