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Studies on the glycosylation of N-acetylneuraminic acid

, 1987
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N-acetylneuraminic acid and sialoglycoconjugate metabolism in fibroblasts from a patient with generalized N-acetylneuraminic acid storage disease

Biochimica Et Biophysica Acta - General Subjects, 1983
Cultured skin fibroblasts from a patient suffering from generalized N-acetylneuraminic acid storage disease were found to accumulate large amounts (approx. 4.0 mumol/g fresh weight) of free N-acetylneuraminic acid in a lysosome-enriched subcellular fraction.
Glyn Dawson, Larry W Hancock, Allen L Horwitz   +2 more
exaly   +3 more sources

A monoclonal antibody to free N-acetylneuraminic acid

Biochimica Et Biophysica Acta - General Subjects, 1990
A monoclonal antibody (70-A) to free N-acetylneuraminic acid was obtained by immunizing mice with its synthetic beta-glycoside, sodium O-[(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-2- nonulopyranosyl)onate]-(2----3)-1,2-di-O-tetradecyl-sn-glyce rol, followed by fusing the isolated spleen cells with mouse myeloma cells and cloning positive ...
Kenkichi Tomita
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The biosynthesis of N-acetylneuraminic acid

Biochemical and Biophysical Research Communications, 1961
Abstract This communication describes a new enzyme system which catalyzes the synthesis of N -acetylneuraminic acid (NANA) from N -acetylmannosamine and phosphoenolpyruvic acid in the presence of ATP. It differs from N -acetylneuraminic acid aldolase (Comb and Roseman, 1960) which catalyzes the synthesis of NANA from N ...
L, WARREN, H, FELSENFELD
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Configuration of N-acetylneuraminic Acid

Nature, 1958
RECENTLY, Comb and Roseman1 observed that N-acetyl-d-mannosamine and not N-acetyl-d-glucosamine was a substrate for the enzyme synthesizing N-acetylneuraminic acid (nanaldolase) isolated from Clostridium perfringens. These results seem to be in conflict with the synthesis of N-acetylneuramic acid from N-acetyl-d-glucosamine as reported by Corn-forth ...
J, BRUG, G B, PAERELS
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Synthesis of N-acetylneuraminic acid

Experientia, 1963
Die Synthese der N-Acetylneuraminsaure aus N-Acetylmannosamin und Oxalessigsaure und die Isolierung eines Zwischenproduktes, 2-Keto-3-deoxy-3-carboxy-5-N-acetylnonulosaminsaure wird beschrieben.
H, RINDERKNECHT, T, REBANE
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Alkylation of N-acetylneuraminic acid at C-4

Carbohydrate Research, 1995
exaly   +3 more sources

An efficient process for production of n-acetylneuraminic acid using n-acetylneuraminic acid aldolase

Enzyme and Microbial Technology, 1997
N-acetyl-D-neuraminic acid (Neu5Ac) aldolase (EC 4.1.3.3) has bee reported for synthesis of Neu5Ac,1-5 but there are no reports of processes which do not have significant drawbacks for large-scale operation. Here, Neu5Ac aldolase from an overexpressing recombinant strain of Escherichia coli has been used to develop an immobilized enzyme process for ...
M, Mahmoudian, D, Noble, C S, Drake, R F, Middleton, D S, Montgomery, J E, Piercey, D, Ramlakhan, M, Todd, M J, Dawson   +8 more
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N-Acetylneuraminic Acid: Neoglycoproteins and Pseudopolysaccharides

Journal of Carbohydrate Chemistry, 1987
Abstract A simplified procedure for the synthesis of acetochloroneuraminic acid is described starting from the methyl ester. N-acetyl neuraminic acid α-allyl glycoside was prepared in high yield using silver salicylate as catalyst. Reductive ozonolysis of the allyl group, followed by direct reductive ami nation to protein carriers, gave immunogenic ...
Roy, René, Laferrière, Craig A., Gamian, Andrzej, Jennings, Harold J.   +3 more
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Synthesis of a carbocyclic analogue of N-acetylneuraminic acid (pseudo-N-acetylneuraminic acid)

Journal of the Chemical Society, Chemical Communications, 1992
A carbocyclic analogue of N-acetylneuraminic acid was synthesized from the Diels–Alder endo-adduct of furan and acrylic acid, and its ammonium salt was subjected to biological assay.
Seiichiro Ogawa, Masaru Yoshikawa, Toshiaki Taki   +2 more
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