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N-Acetylneuraminic acid storage disease
Human Genetics, 1985Increased amounts of free sialic acid were found in body fluids, leukocytes, cultured fibroblasts, and liver tissue of a four-year-old boy with mental retardation, ataxia, and clinical and radiologic findings of a mild mucopolysaccharidosis. A diagnosis of Salla disease was made though in contrast to earlier reports, recurrent upper respiratory ...
J, Baumkötter +6 more
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Glycosidation of N-acetylneuraminic acid
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1968The synthesis of the methyl esters of 9-O-(β-D-glucopyranosyl)- and 9-O-(β-D-galaetopyranosyl)-N-acetylneuraminic acid is described.
A. Ya. Khorlin, I. M. Privalova
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Acylation of N-acetylneuraminic acid
Chemistry of Natural Compounds, 1967The direct acylation of N-acetylneuraminic acid takes place ambiguously and leads to two reaction products: the acylated γ-lactone and the acylated derivative of the pyranose form of the acid.
A. Ya. Khorlin, I. M. Privalova
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The Journal of Nutrition, 1986
Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of
S E, Carlson, S G, House
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Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of
S E, Carlson, S G, House
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N-acetylneuraminic acid and hostile mucus infertility
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1987A total of 39 samples of hostile mucus, as defined by postcoital examination, were examined for N-acetylneuraminic acid (NANA) deficiency, as measured by the enzymatic addition of NANA, spermatozoal penetration and immobilization. Only 56.7% of the mucus samples were deficient in NANA and this did not correlate with spermatozoal penetration or ...
Polak B., Daunter B.
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Bioorganic & Medicinal Chemistry, 2000
Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
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Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
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The first synthesis of N-acetylneuraminic acid 1,7-lactone
Chemical Communications, 2008N -Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N -acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative ...
R. Colombo +3 more
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Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid
2018Investigations of methodologies aimed on improving the stereoselective synthesis of sialosides and the efficient assembly of sialic acid glycoconjugates has been the mission of dedicated research groups from the late 1960s. This review presents major accomplishments in the field, with the emphasis on significant breakthroughs and influential synthetic ...
Cristina, De Meo, Bradley T, Jones
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The benzhydryl ester of N-acetylneuraminic acid
Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966Benzhydryl protection of the carboxy group of N-acetylneuraminic acid has been described for the first time.
A. Ya. Khorlin, I. M. Privalova
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An improved synthesis of n-acetylneuraminic acid
Carbohydrate Research, 1969Abstract The overall yield and stereoselectivity of the aldol condensation reactions of 2-acetamido-2-deoxy- D -glucose and 2-acetamido-2-deoxy- D -mannose with oxal-acetate at pH 10 are improved by the incorporation of borate ion in the reaction mixture. Borate ion inhibits the alkaline epimerisation of various 2-acylamino-2-deoxyaldoses.
M.J. How +3 more
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