Results 121 to 130 of about 18,596 (141)
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ChemInform Abstract: Pathways for the Hydrolysis of Glycosides of N‐Acetylneuraminic Acid
ChemInform, 1992AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Xumin Guo +2 more
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A first synthesis of sulfonic acid analogues of N-acetylneuraminic acid
Tetrahedron Letters, 2008Abstract Sulfonic acid analogues of N -acetylneuraminic are synthesized from 1-thio- l -fucoside derivatives with the introduction of an azido group at C-4 of the fucose moiety and carbanionic addition onto fully protected lactones. The analogues in the form of methyl glycosides are subjected to a neuraminidase inhibition assay.
András Lipták +6 more
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Methylumbelliferyl-N-acetylneuraminic acid sialidase in human liver
Biochemical Medicine, 1984Human liver sialidase was measured using methylumbelliferyl-N-acetylneuraminic acid as a substrate. The enzyme activity was linear for only 20 min and linearity was not improved by adding albumin, CaCl2, dithiothreitol, or Ep-459. The optimal pH was 4.5 and the apparent Km value, approximately 0.090 mM.
S. Scharpe, W.R. den Tandt
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Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid
2018Investigations of methodologies aimed on improving the stereoselective synthesis of sialosides and the efficient assembly of sialic acid glycoconjugates has been the mission of dedicated research groups from the late 1960s. This review presents major accomplishments in the field, with the emphasis on significant breakthroughs and influential synthetic ...
Cristina De Meo, Bradley T Jones
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The first synthesis of N-acetylneuraminic acid 1,7-lactone
Chemical Communications, 2008N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis.
R. Colombo +3 more
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Stereoselective synthesis of 2-thioglycosides of N-acetylneuraminic acid
Carbohydrate Research, 1989Treatment of methyl 5-acetamido-2,4,7,8,9-penta-O-acetyl-3,5-dideoxy-β-d-glycero-d-galacto-2-nonulopyranosonate (1) severally with thiophenol, phenylmethanethiol, and ethanethiol in the presence of boron trifluoride etherate gave the corresponding 2-thio-β-glycosides 3–5.
MARRA, Alberto, SINAY P.
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CMP-N-acetylneuraminic acid: Is it synthesized in the nucleus
Glycoconjugate Journal, 1986RadioactiveN-acetylmannosamine was injected intravenously into rats to labelN-acetylneuraminic acid (NeuAc) and CMP-NeuAc. Nuclei were isolated from the livers using a non-aqueous technique to prevent leakage of polar metabolites. A preparation was obtained, which was eight times enriched in nuclei based on the ratio DNA/RNA.
Johanna van Rinsum +2 more
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ChemInform Abstract: Alkylation of N‐Acetylneuraminic Acid at C‐4.
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Monatshefte f�r Chemie Chemical Monthly, 1989
Readily available Neu5Ac derivatives1 and7 are oxidized by RuO4 to the ketones2 and8 which are reduced diastereoselectively by the borane-ammonia complex to yield the4- and 8-epimers4a and10. Subsequent deprotection leads to the title compounds5 and12. This few step procedure is also applicable on gram scale.
E. Zbiral, M. Hartmann
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Readily available Neu5Ac derivatives1 and7 are oxidized by RuO4 to the ketones2 and8 which are reduced diastereoselectively by the borane-ammonia complex to yield the4- and 8-epimers4a and10. Subsequent deprotection leads to the title compounds5 and12. This few step procedure is also applicable on gram scale.
E. Zbiral, M. Hartmann
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Distribution of free N-acetylneuraminic acid in rat organs
Life Sciences, 1989The concentration of free N-acetylneuraminic acid in various rat organs was estimated by gas chromatography/mass spectrometry. Its concentration was in the range of 3.95 to 104.72 micrograms/g wet tissues, being particularly high in the endocrine glands.
Takeshi Miyata +3 more
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