Results 151 to 160 of about 15,535,889 (203)
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Synthesis of a carbocyclic analogue of N-acetylneuraminic acid (pseudo-N-acetylneuraminic acid)
Journal of the Chemical Society, Chemical Communications, 1992A carbocyclic analogue of N-acetylneuraminic acid was synthesized from the Diels–Alder endo-adduct of furan and acrylic acid, and its ammonium salt was subjected to biological assay.
Seiichiro Ogawa +2 more
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N-Acetylneuraminic acid storage disease
Human Genetics, 1985Increased amounts of free sialic acid were found in body fluids, leukocytes, cultured fibroblasts, and liver tissue of a four-year-old boy with mental retardation, ataxia, and clinical and radiologic findings of a mild mucopolysaccharidosis. A diagnosis of Salla disease was made though in contrast to earlier reports, recurrent upper respiratory ...
J, Baumkötter +6 more
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Acylation of N-acetylneuraminic acid
Chemistry of Natural Compounds, 1967The direct acylation of N-acetylneuraminic acid takes place ambiguously and leads to two reaction products: the acylated γ-lactone and the acylated derivative of the pyranose form of the acid.
A. Ya. Khorlin, I. M. Privalova
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Glycosidation of N-acetylneuraminic acid
Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1968The synthesis of the methyl esters of 9-O-(β-D-glucopyranosyl)- and 9-O-(β-D-galaetopyranosyl)-N-acetylneuraminic acid is described.
A. Ya. Khorlin, I. M. Privalova
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The Journal of Nutrition, 1986
Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of
S E, Carlson, S G, House
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Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of
S E, Carlson, S G, House
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N-acetylneuraminic acid and hostile mucus infertility
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1987A total of 39 samples of hostile mucus, as defined by postcoital examination, were examined for N-acetylneuraminic acid (NANA) deficiency, as measured by the enzymatic addition of NANA, spermatozoal penetration and immobilization. Only 56.7% of the mucus samples were deficient in NANA and this did not correlate with spermatozoal penetration or ...
Polak B., Daunter B.
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A monoclonal antibody to free N-acetylneuraminic acid
Biochimica et Biophysica Acta (BBA) - General Subjects, 1990A monoclonal antibody (70-A) to free N-acetylneuraminic acid was obtained by immunizing mice with its synthetic beta-glycoside, sodium O-[(5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-2- nonulopyranosyl)onate]-(2----3)-1,2-di-O-tetradecyl-sn-glyce rol, followed by fusing the isolated spleen cells with mouse myeloma cells and cloning positive ...
A, Kawamura +7 more
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Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
Cultured skin fibroblasts from a patient suffering from generalized N-acetylneuraminic acid storage disease were found to accumulate large amounts (approx. 4.0 mumol/g fresh weight) of free N-acetylneuraminic acid in a lysosome-enriched subcellular fraction.
L W, Hancock, A L, Horwitz, G, Dawson
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Cultured skin fibroblasts from a patient suffering from generalized N-acetylneuraminic acid storage disease were found to accumulate large amounts (approx. 4.0 mumol/g fresh weight) of free N-acetylneuraminic acid in a lysosome-enriched subcellular fraction.
L W, Hancock, A L, Horwitz, G, Dawson
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Bioorganic & Medicinal Chemistry, 2000
Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
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Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase. Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.
Kiefel, MJ +4 more
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The benzhydryl ester of N-acetylneuraminic acid
Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966Benzhydryl protection of the carboxy group of N-acetylneuraminic acid has been described for the first time.
A. Ya. Khorlin, I. M. Privalova
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