Results 161 to 170 of about 15,535,889 (203)

Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid

2018
Investigations of methodologies aimed on improving the stereoselective synthesis of sialosides and the efficient assembly of sialic acid glycoconjugates has been the mission of dedicated research groups from the late 1960s. This review presents major accomplishments in the field, with the emphasis on significant breakthroughs and influential synthetic ...
Cristina, De Meo, Bradley T, Jones
openaire   +2 more sources

An improved synthesis of n-acetylneuraminic acid

Carbohydrate Research, 1969
Abstract The overall yield and stereoselectivity of the aldol condensation reactions of 2-acetamido-2-deoxy- D -glucose and 2-acetamido-2-deoxy- D -mannose with oxal-acetate at pH 10 are improved by the incorporation of borate ion in the reaction mixture. Borate ion inhibits the alkaline epimerisation of various 2-acylamino-2-deoxyaldoses.
M.J. How, M.D.A. Halford, M. Stacey, E. Vickers   +3 more
openaire   +1 more source

Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid

Tetrahedron: Asymmetry, 1994
Abstract 7-Deoxy- N -acetylneuraminic Acid and 7- O -methyl- N -acetylneuraminic acid were synthesized through the sialic acid aldolase-catalyzed aldol addition reactions of 4-deoxy- N -acetyl-D-mannosamine and 4- O -methyl- N -acetyl-D-mannosamine, respectively, with pyruvate. The obtained sialic acids will be used as probes for the investigation of
Randall L. Halcomb, Wolfgang Fitz, Chi-Huey Wong   +2 more
openaire   +1 more source

Metabolism of N-acetylneuraminic acid in mammals: isolation and characterization of CMP-N-acetylneuraminic acid

Biochemistry, 1979
D J, Carey, C B, Hirschberg
openaire   +2 more sources

The enzymic cleavage of N-acetylneuraminic acid

Biochimica et Biophysica Acta, 1959
J, BRUG, R J, ESSER, G B, PAERELS
openaire   +2 more sources

CMP-N-acetylneuraminic Acid Hydroxylase

2009
CMP-N-acetylneuraminic acid (CMP-NeuAc) hydroxylase catalyzes the hydroxylation of CMP-NeuAc to CMP-N-glycolylneuraminic acid (CMP-NeuGc) in the presence of hydrogen donor (NADH), cytochrome b5, and NADH-cytochrome b5 reductase (Kozutsumi et al. 1990; Kawano et al. 1994). This biosynthetic step is the rate limiting reaction for the expression of NeuGc,
openaire   +1 more source

Engineering of an -acetylneuraminic acid synthetic pathway in

Metabolic Engineering, 2012
Qingsheng Qi, Yang Wang, Pengfei Gu
exaly  

-acetylneuraminic acid and sialoglycoconjugate metabolism in fibroblasts from a patient with generalized -acetylneuraminic acid storage disease

Biochimica Et Biophysica Acta - General Subjects, 1983
Glyn Dawson, Allen L Horwitz, Larry W Hancock   +2 more
exaly  

MICROORGANISM HAVING ABILITY TO PRODUCE N-ACETYLNEURAMINIC ACID AND/OR N-ACETYLNEURAMINIC ACID-CONTAINING CARBOHYDRATE AND METHOD FOR PRODUCING N-ACETYLNEURAMINIC ACID AND/OR N-ACETYLNEURAMINIC ACID-CONTAINING CARBOHYDRATE USING SAID MICROORGANISM

2023
NAOE TAIKI, UJIHARA TETSURO
openaire   +1 more source

Synthesis of novel -acetylneuraminic acid derivatives as substrates for rapid detection of influenza virus neuraminidase

Carbohydrate Research, 2012
X James Li, Yifa Zhou, Guihua Tai
exaly