Results 1 to 10 of about 13,352,036 (198)
Nature Communications, 2022 Poor peptide fragmentation and unusual glycan structures limit mass spectrometry-based analysis of intact N-glycopeptides. Here, the authors develop Glyco-Decipher, a glycan-independent peptide search tool, to tackle these issues and improve the coverage
Zheng Fang +9 more
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Bioengineering, 2023 Analytical methods fr direct quantitative N-glycan analysis require a sequence of sample preparation and clean-up steps that result in reduced glycan recovery. Therefore, we aimed to combine glycan release and labeling steps. Based on the hypothesis that
Mumtaz Kasim +8 more
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Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling. [PDF]
PLoS Computational Biology, 2013 Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions.
Sunhwan Jo +3 more
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Production and N-glycan engineering of Varlilumab in Nicotiana benthamiana
Frontiers in Plant Science, 2023 N-glycan engineering has dramatically evolved for the development and quality control of recombinant antibodies. Fc region of IgG contains two N-glycans whose galactose terminals on Fc-glycan have been shown to increase the stability of CH2 domain and ...
Kim Dua Nguyen +9 more
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The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts
Frontiers in Molecular Biosciences, 2022 Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market.
Mari A. Piirainen +2 more
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Site-specific glycan analysis of the SARS-CoV-2 spike
Science, 2020 SARS-CoV-2 spike protein, elaborated Vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on the trimeric spike protein that initiates infection.
Yasunori Watanabe +4 more
semanticscholar +1 more source
The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation
Frontiers in Plant Science, 2023 IntroductionThe Golgi apparatus of plants is the central cellular organelle for glycan processing and polysaccharide biosynthesis. These essential processes are catalyzed by a large number of Golgi-resident glycosyltransferases and glycosidases whose ...
Jennifer Schoberer +8 more
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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Nature Communications, 2020 Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential.
Yasunori Watanabe +10 more
semanticscholar +1 more source
The Structural Difference of Isobaric N-Glycans of Two Microalgae Samples Reveals Taxonomic Distance
Frontiers in Plant Science, 2021 Microalgae of the Chlorella clade are extensively investigated as an environmentally friendly source of renewable biofuels and high-value nutrients. In addition, essentially unprocessed Chlorella serves as wholesome food additive.
Réka Mócsai +5 more
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The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus
Scientific Reports, 2020 Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and glycosphingolipid-glycans from total human lungs, along with ...
Nan Jia +8 more
semanticscholar +1 more source