Results 1 to 10 of about 81,882 (165)
Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades. [PDF]
Mol Cell ProteomicsWe characterized the N-glycosylation profiles of anhydrobiotic tardigrades, R. varieornatus and H. exemplaris, identifying high-mannose, paucimannose, and complex-type oligosaccharides, while hybrid-type glycans were undetectable. Notably, paucimannose-type oligosaccharides accounted for 39% of the N-glycans in R. varieornatus and 17% in H. exemplaris,
Yagi H +12 more
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Species-specific N-glycan patterns in animal and human breast milk samples [PDF]
Frontiers in NutritionThe main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret +6 more
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Identification of a free-N-glycan with difucosylated type-1 lactosamine in cancerous tissue and its validation for cancer diagnosis by urinary testing [PDF]
Scientific ReportsNumerous urinary acidic free-glycan tumor marker candidates have been identified based on the glycan structure profiles of human cancer tissues. In this study, to identify novel glycan tumor markers, we performed precise glycan structural analysis ...
Miki Tanaka-Okamoto +8 more
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Recent advances in N-glycan biomarker discovery among human diseases. [PDF]
Acta Biochim Biophys Sin (Shanghai)N-glycans play important roles in a variety of biological processes. In recent years, analytical technologies with high resolution and sensitivity have advanced exponentially, enabling analysts to investigate N-glycomic changes in different states. Specific glycan and glycosylation signatures have been identified in multiple diseases, including cancer,
Wang Y, Liu Y, Liu S, Cheng L, Liu X.
europepmc +2 more sources
Bioengineering, 2023 Analytical methods fr direct quantitative N-glycan analysis require a sequence of sample preparation and clean-up steps that result in reduced glycan recovery. Therefore, we aimed to combine glycan release and labeling steps. Based on the hypothesis that
Mumtaz Kasim +8 more
doaj +1 more source
Production and N-glycan engineering of Varlilumab in Nicotiana benthamiana
Frontiers in Plant Science, 2023 N-glycan engineering has dramatically evolved for the development and quality control of recombinant antibodies. Fc region of IgG contains two N-glycans whose galactose terminals on Fc-glycan have been shown to increase the stability of CH2 domain and ...
Kim Dua Nguyen +9 more
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The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts
Frontiers in Molecular Biosciences, 2022 Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market.
Mari A. Piirainen +2 more
doaj +1 more source
Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling. [PDF]
PLoS Computational Biology, 2013 Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions.
Sunhwan Jo +3 more
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An Integrative Glycomic Approach for Quantitative Meat Species Profiling
Foods, 2022 It is estimated that food fraud, where meat from different species is deceitfully labelled or contaminated, has cost the global food industry around USD 6.2 to USD 40 billion annually.
Sean Chia +8 more
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N-Glycans in cancer progression [PDF]
Glycobiology, 2008 N-Glycan branching in the medial-Golgi generates ligands for lattice-forming lectins (e.g., galectins) that regulate surface levels of glycoproteins including epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) receptors. Moreover, functional classes of glycoproteins differ in N-glycan multiplicities (number of N-glycans ...
Ken S, Lau, James W, Dennis
openaire +2 more sources