Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling. [PDF]
PLoS Computational Biology, 2013 Understanding glycan structure and dynamics is central to understanding protein-carbohydrate recognition and its role in protein-protein interactions.
Sunhwan Jo +3 more
doaj +1 more source
The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation
Frontiers in Plant Science, 2023 IntroductionThe Golgi apparatus of plants is the central cellular organelle for glycan processing and polysaccharide biosynthesis. These essential processes are catalyzed by a large number of Golgi-resident glycosyltransferases and glycosidases whose ...
Jennifer Schoberer +8 more
doaj +1 more source
An Integrative Glycomic Approach for Quantitative Meat Species Profiling
Foods, 2022 It is estimated that food fraud, where meat from different species is deceitfully labelled or contaminated, has cost the global food industry around USD 6.2 to USD 40 billion annually.
Sean Chia +8 more
doaj +1 more source
Site-specific glycan analysis of the SARS-CoV-2 spike
Science, 2020 SARS-CoV-2 spike protein, elaborated Vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on the trimeric spike protein that initiates infection.
Yasunori Watanabe +4 more
semanticscholar +1 more source
N-Glycans in cancer progression [PDF]
Glycobiology, 2008 N-Glycan branching in the medial-Golgi generates ligands for lattice-forming lectins (e.g., galectins) that regulate surface levels of glycoproteins including epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) receptors. Moreover, functional classes of glycoproteins differ in N-glycan multiplicities (number of N-glycans ...
Ken S, Lau, James W, Dennis
openaire +2 more sources
Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]
, 2018 Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J +5 more
core +6 more sources
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Nature Communications, 2020 Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic potential.
Yasunori Watanabe +10 more
semanticscholar +1 more source
Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues
Nature Communications, 2022 Glycosylation is essential to brain development and function, but prior studies have often been limited to a single analytical technique and excluded region- and sex-specific analyses.
Sarah E. Williams +9 more
semanticscholar +1 more source
Seed-produced anti-globulin VHH-Fc antibodies retrieve globulin precursors in the insoluble fraction and modulate the Arabidopsis thaliana seed subcellular morphology [PDF]
, 2020 Key message Nanobody-heavy chain (VHH-Fc) antibody formats have the potential to immunomodulate even highly accumulating proteins and provide a valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.
Altmann, Friedrich +7 more
core +2 more sources
Engineering, 2023 The aim of this study was to explore the role of serum N-glycomic-derived models in diagnosing significant liver fibrosis and cirrhosis in 285 chronic hepatitis B (CHB) patients with normal (
Lin Wang +9 more
doaj +1 more source