Results 11 to 20 of about 13,352,036 (198)

Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N‐Glycan Library for Functional Glycomics [PDF]

Advanced Science, 2023
N‐Glycosylation, a main post‐translational modification of Immunoglobulin G (IgG), plays a significant role in modulating the immune functions of IgG. However, the precise function elucidation of IgG N‐glycosylation remains impeded due to the obstacles ...
Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li   +6 more
doaj   +2 more sources

One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure [PDF]

eLife
Both endogenous antibodies and a subset of antibody therapeutics engage Fc gamma receptor (FcγR)IIIa/CD16a to stimulate a protective immune response. Increasing the FcγRIIIa/IgG1 interaction improves the immune response and thus represents a strategy to ...
Paul G Kremer, Elizabeth A Lampros, Allison M Blocker, Adam W Barb   +3 more
doaj   +2 more sources

FUT8-Directed Core Fucosylation of N-glycans Is Regulated by the Glycan Structure and Protein Environment

ACS Catalysis, 2021
FUT8 is an essential α-1,6-fucosyltransferase that fucosylates the innermost GlcNAc of N-glycans, a process called core fucosylation. In vitro, FUT8 exhibits substrate preference for the biantennary complex N-glycan oligosaccharide (G0), but the role of ...
A. García-García, Sonia Serna, Zhang Yang, I. Delso, V. Taleb, T. Hicks, R. Artschwager, S. Vakhrushev, H. Clausen, J. Angulo, F. Corzana, N. Reichardt, R. Hurtado‐Guerrero   +12 more
semanticscholar   +1 more source

An Integrative Glycomic Approach for Quantitative Meat Species Profiling

Foods, 2022
It is estimated that food fraud, where meat from different species is deceitfully labelled or contaminated, has cost the global food industry around USD 6.2 to USD 40 billion annually.
Sean Chia, Gavin Teo, Shi Jie Tay, Larry Sai Weng Loo, Corrine Wan, Lyn Chiin Sim, Hanry Yu, Ian Walsh, Kuin Tian Pang   +8 more
doaj   +1 more source

CHARMM-GUI Glycan Modeler for modeling and simulation of carbohydrates and glycoconjugates

Glycobiology, 2019
Characterizing glycans and glycoconjugates in the context of three-dimensional structures is important in understanding their biological roles and developing efficient therapeutic agents.
Sang-Jun Park, Jumin Lee, Yifei Qi, Nathan R. Kern, Hui-Sun Lee, Sunhwan Jo, InSuk Joung, K. Joo, Jooyoung Lee, W. Im   +9 more
semanticscholar   +1 more source

Site-specific analysis of the SARS-CoV-2 glycan shield

bioRxiv, 2020
The emergence of the betacoronavirus, SARS-CoV-2 that causes COVID-19, represents a significant threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, that ...
Yasunori Watanabe, Joel D. Allen, D. Wrapp, J. McLellan, M. Crispin   +4 more
semanticscholar   +1 more source

Pn-AqpC-Mediated Fermentation Pattern Coordination with the Two-Component System 07 Regulates Host N-Glycan Degradation of Streptococcus pneumoniae

Microbiology Spectrum, 2022
The opportunistic pathogen Streptococcus pneumoniae (pneumococcus) is a human nasopharyngeal commensal, and host N-glycan metabolism promotes its colonization and invasion.
Kaiqiang Shen, Qingqing Hu, Lin Zhu, Wenshuang Miu, Yuzhu Dong, Fu Ren, Xiuzhu Dong, Huichun Tong   +7 more
doaj   +1 more source

A common glycan structure on immunoglobulin G for enhancement of effector functions

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Antibodies are important therapeutic agents and have been used for the treatment of many diseases, including infectious and inflammatory diseases, and cancer.
Chin-Wei Lin, M. Tsai, Shiou-Ting Li, Tsung-I Tsai, Kuo-Ching Chu, Ying-Chih Liu, M. Lai, Chia-Yu Wu, Yung-Chieh Tseng, Sachin S Shivatare, Chia-Hung Wang, Ping Chao, Shi-Yun Wang, H. Shih, Yi-fang Zeng, Tsai-Hong You, Jung-Yu Liao, Yu-Chen Tu, Yih‐Shyan Lin, Hong-Yang Chuang, Chia-Lin Chen, Charng-Sheng Tsai, Chiu-Chen Huang, N. Lin, Che Ma, Chung-Yi Wu, Chi-Huey Wong   +26 more
semanticscholar   +1 more source

The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

Scientific Reports, 2017
N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits.
Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu   +4 more
doaj   +1 more source

The Mechanism by which 146-N-Glycan Affects the Active Site of Neuraminidase. [PDF]

PLoS ONE, 2015
One of the most conserved glycosylation sites of neuraminidase (NA) is 146-N-glycan. This site is adjacent to the 150-cavity of NA, which is found within the active site and thought to be a target for rational drug development against the antiviral ...
Pi Liu, Zhonghua Wang, Lijie Zhang, Dongmei Li, Jianping Lin   +4 more
doaj   +1 more source