Results 21 to 30 of about 13,066,219 (329)
Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies
iScience, 2020 Summary: HIV-1 envelope (Env) N-glycosylation impact virus-cell entry and immune evasion. How each glycan interacts to shape the Env-protein-sugar complex and affects Env function is not well understood.
Qing Wei +18 more
doaj +1 more source
The Structural Difference of Isobaric N-Glycans of Two Microalgae Samples Reveals Taxonomic Distance
Frontiers in Plant Science, 2021 Microalgae of the Chlorella clade are extensively investigated as an environmentally friendly source of renewable biofuels and high-value nutrients. In addition, essentially unprocessed Chlorella serves as wholesome food additive.
Réka Mócsai +5 more
doaj +1 more source
The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus
Scientific Reports, 2020 Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and glycosphingolipid-glycans from total human lungs, along with ...
Nan Jia +8 more
semanticscholar +1 more source
CHARMM-GUI Glycan Modeler for modeling and simulation of carbohydrates and glycoconjugates
Glycobiology, 2019 Characterizing glycans and glycoconjugates in the context of three-dimensional structures is important in understanding their biological roles and developing efficient therapeutic agents.
Sang-Jun Park +9 more
semanticscholar +1 more source
From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]
, 2009 Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine +4 more
core +1 more source
Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]
, 2020 Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico +6 more
core +1 more source
ACS Catalysis, 2021 FUT8 is an essential α-1,6-fucosyltransferase that fucosylates the innermost GlcNAc of N-glycans, a process called core fucosylation. In vitro, FUT8 exhibits substrate preference for the biantennary complex N-glycan oligosaccharide (G0), but the role of ...
A. García-García +12 more
semanticscholar +1 more source
Microbiology Spectrum, 2022 The opportunistic pathogen Streptococcus pneumoniae (pneumococcus) is a human nasopharyngeal commensal, and host N-glycan metabolism promotes its colonization and invasion.
Kaiqiang Shen +7 more
doaj +1 more source
The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation
Scientific Reports, 2017 N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits.
Xiulei Cai +4 more
doaj +1 more source
Journal of Proteome Research, 2018 Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum glycosylation have long been associated with this cancer but the source of that material is unknown ...
Connor A. West +7 more
semanticscholar +1 more source