Results 21 to 30 of about 13,352,036 (198)

Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]

The EMBO Journal 27, 9 (2008) 1321-1332, 2008
The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv   +1 more source

N-Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging.

Journal of Proteome Research, 2018
Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum glycosylation have long been associated with this cancer but the source of that material is unknown ...
Connor A. West, Mengjun Wang, Harmin Herrera, Hongyan Liang, Alyson P. Black, P. Angel, R. Drake, A. Mehta   +7 more
semanticscholar   +1 more source

Clinical implications of serum N‐glycan profiling as a diagnostic and prognostic biomarker in germ‐cell tumors

Cancer Medicine, 2017
Serum biomarker monitoring is essential for management of germ‐cell tumors (GCT). However, not all GCT are positive for conventional tumor markers. We examined whether serum N‐glycan‐based biomarkers can be applied for detection and prognosis in patients
Takuma Narita, Shingo Hatakeyama, Tohru Yoneyama, Shintaro Narita, Shinichi Yamashita, Koji Mitsuzuka, Toshihiko Sakurai, Sadafumi Kawamura, Tatsuo Tochigi, Ippei Takahashi, Shigeyuki Nakaji, Yuki Tobisawa, Hayato Yamamoto, Takuya Koie, Norihiko Tsuchiya, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama   +17 more
doaj   +1 more source

Effect of vitamin D supplementation on N‐glycan branching and cellular immunophenotypes in MS

Annals of Clinical and Translational Neurology, 2020
Objective To investigate the effect of cholecalciferol (vitamin D3) supplementation on peripheral immune cell frequency and N‐glycan branching in patients with relapsing‐remitting multiple sclerosis (RRMS).
Priscilla Bäcker‐Koduah, Carmen Infante‐Duarte, Federico Ivaldi, Antonio Uccelli, Judith Bellmann‐Strobl, Klaus‐Dieter Wernecke, Michael Sy, Michael Demetriou, Jan Dörr, Friedemann Paul, Alexander Ulrich Brandt   +10 more
doaj   +1 more source

Transient Production of Human β-Glucocerebrosidase With Mannosidic-Type N-Glycan Structure in Glycoengineered Nicotiana benthamiana Plants

Frontiers in Plant Science, 2021
Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak, Hiroyuki Kajiura, Hiroyuki Kajiura, Ryo Misaki, Ryo Misaki, Kazuhito Fujiyama, Kazuhito Fujiyama, Kazuhito Fujiyama   +7 more
doaj   +1 more source

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.

Proceedings of the National Academy of Sciences of the United States of America, 2004
Here we describe a glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide. The array comprises 200 synthetic and natural glycan sequences representing
O. Blixt, Steve Head, T. Mondala, Christopher N. Scanlan, M. Huflejt, R. Alvarez, M. Bryan, Fabio Fazio, D. Calarese, J. Stevens, N. Razi, D. Stevens, J. Skehel, I. van Die, D. Burton, I. Wilson, R. Cummings, N. Bovin, Chi‐Huey Wong, J. Paulson   +19 more
semanticscholar   +1 more source

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

Journal of Biological Chemistry, 2018
Galectins compose a protein family defined by a conserved sequence motif conferring affinity for β-galactose–containing glycans. Moreover, galectins gain higher affinity and fine-tune specificity by glycan interactions at sites adjacent to their β ...
Mathias A I Nielsen, J. Stegmayr, Oliver C. Grant, Zhang Yang, U. Nilsson, I. Boos, Michael C. Carlsson, R. Woods, C. Unverzagt, H. Leffler, H. Wandall   +10 more
semanticscholar   +1 more source

Glycan profiling shows unvaried N-glycomes in MSC clones with distinct differentiation potentials

Frontiers in Cell and Developmental Biology, 2016
Different cell types have different N-glycomes in mammals. This means that cellular differentiation is accompanied by changes in the N-glycan profile. Yet when the N-glycomes of cell types with differing fates diverge is unclear. We have investigated the
Katherine Mary Wilson, Jane Elizabeth Thomas-Oates, Paul eGenever, Daniel eUngar   +3 more
doaj   +1 more source

Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody

Nature Communications, 2023
Immunoglobulin G (IgG) antibodies contain a complex N-glycan embedded in the hydrophobic pocket between its heavy chain protomers. This glycan contributes to the structural organization of the Fc domain and determines its specificity for Fcγ receptors ...
Aaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch   +8 more
doaj   +1 more source

N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients.

Journal of Proteome Research, 2012
Glycosylated proteins play important roles in a broad spectrum of biochemical and biological processes, and prior reports have suggested that changes in protein glycosylation occur during cancer initiation and progression.
W. Alley, Jacqueline A Vasseur, John A. Goetz, M. Svoboda, B. Mann, D. Matei, N. Menning, A. Hussein, Y. Mechref, M. Novotny   +9 more
semanticscholar   +1 more source