Results 31 to 40 of about 13,066,219 (329)
Studying Lactoferrin N-Glycosylation. [PDF]
, 2017 Lactoferrin is a multifunctional glycoprotein found in the milk of most mammals. In addition to its well-known role of binding iron, lactoferrin carries many important biological functions, including the promotion of cell proliferation and ...
Barile, Daniela +4 more
core +3 more sources
Advanced Science, 2023 N‐Glycosylation, a main post‐translational modification of Immunoglobulin G (IgG), plays a significant role in modulating the immune functions of IgG. However, the precise function elucidation of IgG N‐glycosylation remains impeded due to the obstacles ...
Wenjing Ma +6 more
doaj +1 more source
A common glycan structure on immunoglobulin G for enhancement of effector functions
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Antibodies are important therapeutic agents and have been used for the treatment of many diseases, including infectious and inflammatory diseases, and cancer.
Chin-Wei Lin +26 more
semanticscholar +1 more source
Comparisons of N-glycans across invertebrate phyla [PDF]
Parasitology, 2019 AbstractMany invertebrates are either parasites themselves or vectors involved in parasite transmission; thereby, the interactions of parasites with final or intermediate hosts are often mediated by glycans. Therefore, it is of interest to compare the glycan structures or motifs present across invertebrate species.
Katharina Paschinger, Iain B. H. Wilson
openaire +2 more sources
Cancer Medicine, 2017 Serum biomarker monitoring is essential for management of germ‐cell tumors (GCT). However, not all GCT are positive for conventional tumor markers. We examined whether serum N‐glycan‐based biomarkers can be applied for detection and prognosis in patients
Takuma Narita +17 more
doaj +1 more source
Effect of vitamin D supplementation on N‐glycan branching and cellular immunophenotypes in MS
Annals of Clinical and Translational Neurology, 2020 Objective To investigate the effect of cholecalciferol (vitamin D3) supplementation on peripheral immune cell frequency and N‐glycan branching in patients with relapsing‐remitting multiple sclerosis (RRMS).
Priscilla Bäcker‐Koduah +10 more
doaj +1 more source
The Mechanism by which 146-N-Glycan Affects the Active Site of Neuraminidase. [PDF]
PLoS ONE, 2015 One of the most conserved glycosylation sites of neuraminidase (NA) is 146-N-glycan. This site is adjacent to the 150-cavity of NA, which is found within the active site and thought to be a target for rational drug development against the antiviral ...
Pi Liu +4 more
doaj +1 more source
Frontiers in Plant Science, 2021 Gaucher disease is an inherited lysosomal storage disorder caused by a deficiency of functional enzyme β-glucocerebrosidase (GCase). Recombinant GCase has been used in enzyme replacement therapy to treat Gaucher disease. Importantly, the terminal mannose
Naphatsamon Uthailak +7 more
doaj +1 more source
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
semanticscholar +1 more source
Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. [PDF]
, 2014 An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity.
An, Hyun Joo +11 more
core +1 more source