Results 31 to 40 of about 13,352,036 (198)
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
semanticscholar +1 more source
Biological significance of complex N-glycans in plants and their impact on plant physiology
Frontiers in Plant Science, 2014 Asparagine (N)-linked protein glycosylation is a ubiquitous co- and post-translational modification which can alter the biological function of proteins and consequently affects the development, growth and physiology of organisms.
Richard eStrasser
doaj +1 more source
Changes in N-glycans of IgG4 and its relationship with the existence of hypocomplementemia and individual organ involvement in patients with IgG4-related disease. [PDF]
PLoS ONE, 2018 Although increased serum IgG4 level and tissue infiltration of IgG4-positive cells are key events in IgG4-related disease (IgG4RD), and nearly half of IgG4RD patients show hypocomplementemia, the role of IgG4 in the pathogenesis of IgG4RD remains unclear.
Naoki Konno +12 more
doaj +1 more source
PLoS ONE, 2017 Lactoferrin (LF) is one of the most abundant bioactive glycoproteins in human milk. Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities. In contrast, LF is present in trace amounts in bovine milk.
Annabelle Le Parc +5 more
doaj +1 more source
PLoS Pathogens, 2015 Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs.
E. Crooks +25 more
semanticscholar +1 more source
Scientific Reports, 2022 Serum N-glycan profiling studies during the past decades have shown robust associations between N-glycan changes and various biological conditions, including infections, in humans.
Laudine M. C. Petralia +10 more
doaj +1 more source
Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling
Scientific Reports, 2016 Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection.
Narine Arabyan +11 more
semanticscholar +1 more source
Improved method for drawing of a glycan map, and the first page of glycan atlas, which is a compilation of glycan maps for a whole organism. [PDF]
PLoS ONE, 2014 Glycan Atlas is a set of glycan maps over the whole body of an organism. The glycan map that includes data of glycan structure and quantity displays micro-heterogeneity of the glycans in a tissue, an organ, or cells. The two-dimensional glycan mapping is
Shunji Natsuka +3 more
doaj +1 more source
Terminal Epitope-Dependent Branch Preference of Siglecs Toward N-Glycans
Frontiers in Molecular Biosciences, 2021 Siglecs are sialic acid–binding immunoglobulin-like lectins that play vital roles in immune cell signaling. Siglecs help the immune system distinguish between self and nonself through the recognition of glycan ligands.
Shuaishuai Wang +10 more
doaj +1 more source
Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile
Diabetes, 2013 A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered
G. Thanabalasingham +39 more
semanticscholar +1 more source